Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review

Detalhes bibliográficos
Autor(a) principal: Júnior, José Reginaldo Alves de Queiroz
Data de Publicação: 2022
Outros Autores: Pereira, Jarson Pedro da Costa, Pires, Leonardo Lucas, Maia, Carina Scanoni
Tipo de documento: Artigo
Idioma: por
Título da fonte: Scientia Medica (Porto Alegre. Online)
DOI: 10.15448/1980-6108.2022.1.42267
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/42267
Resumo: Aim: to evaluate the effectiveness of using the combined therapy of sodium alendronate and vitamin D on bone metabolism in women undergoing postmenopausal osteoporosis. Methods: this is a systematic review. The studies included were Randomized Controlled Trials (RCT) indexed in the BVS, ISI Web of Science, PubMed, SciELO, ScienceDirect and Scopus Databases which compared the association of sodium alendronate and vitamin D to monotherapy of sodium alendronate. Results: a total of six RCT met the criteria to be included in this study, comprising a total of 4164 participants and their respective data. The studies evaluated different domains of bone metabolism, such as serum levels of vitamin D, parathyroid hormone, bone mineral density and bone turnover markers. Combination therapy produced significant improvement in bone metabolic markers. Conclusion: combined therapy of sodium alendronate with vitamin D promotes improved bone metabolism in women with postmenopausal osteoporosis.
id PUC_RS-25_d8a0317f595ac8344e084832d3c1218a
oai_identifier_str oai:ojs.revistaseletronicas.pucrs.br:article/42267
network_acronym_str PUC_RS-25
network_name_str Scientia Medica (Porto Alegre. Online)
spelling Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic reviewAlendronato de sódio e vitamina D na osteoporose pós-menopausa: Revisão sistemáticaosteoporosispostmenopausealendronatevitamin Dbone recoveryosteoporosepós-menopausaalendronatovitamina Drecuperação ósseaAim: to evaluate the effectiveness of using the combined therapy of sodium alendronate and vitamin D on bone metabolism in women undergoing postmenopausal osteoporosis. Methods: this is a systematic review. The studies included were Randomized Controlled Trials (RCT) indexed in the BVS, ISI Web of Science, PubMed, SciELO, ScienceDirect and Scopus Databases which compared the association of sodium alendronate and vitamin D to monotherapy of sodium alendronate. Results: a total of six RCT met the criteria to be included in this study, comprising a total of 4164 participants and their respective data. The studies evaluated different domains of bone metabolism, such as serum levels of vitamin D, parathyroid hormone, bone mineral density and bone turnover markers. Combination therapy produced significant improvement in bone metabolic markers. Conclusion: combined therapy of sodium alendronate with vitamin D promotes improved bone metabolism in women with postmenopausal osteoporosis.Objetivo: avaliar a eficácia da utilização da terapia combinada de alendronato de sódio e vitamina D no metabolismo ósseo de mulheres em tratamento de osteoporose pós-menopausa.Métodos: trata-se de uma revisão sistemática, a qual foram pesquisados ensaios clínicos randomizados (ECR) indexados nas bases de dados BVS, ISI Web of Science, PubMed, SciELO, ScienceDirect e Scopus que comparavam a associação de alendronato sódico e vitamina D com a monoterapia de alendronato de sódio. Resultados: um total de seis ECR contemplou os critérios para serem inclusos nesse estudo, compreendendo um total de 4164 participantes e seus respectivos dados. Os estudos avaliaram diferentes domínios do metabolismo ósseo, como níveis séricos de vitamina D, paratormônio, densidade mineral óssea e marcadores de turnover ósseo. A terapia combinada produziu melhora significativa nos marcadores metabólicos ósseos. Conclusão: a terapia combinada de alendronato de sódio com vitamina D promove melhora no metabolismo ósseo de mulheres com osteoporose pós-menopausa.Editora da PUCRS - ediPUCRS2022-08-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/4226710.15448/1980-6108.2022.1.42267Scientia Medica; Vol. 32 No. 1 (2022): Single Volume; e42267Scientia Medica; v. 32 n. 1 (2022): Volume Único; e422671980-61081806-556210.15448/1980-6108.2022.1reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/42267/27614Copyright (c) 2022 Scientia Medicahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessJúnior, José Reginaldo Alves de QueirozPereira, Jarson Pedro da CostaPires, Leonardo LucasMaia, Carina Scanoni2022-12-16T12:09:43Zoai:ojs.revistaseletronicas.pucrs.br:article/42267Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2022-12-16T12:09:43Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
Alendronato de sódio e vitamina D na osteoporose pós-menopausa: Revisão sistemática
title Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
spellingShingle Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
Júnior, José Reginaldo Alves de Queiroz
osteoporosis
postmenopause
alendronate
vitamin D
bone recovery
osteoporose
pós-menopausa
alendronato
vitamina D
recuperação óssea
Júnior, José Reginaldo Alves de Queiroz
osteoporosis
postmenopause
alendronate
vitamin D
bone recovery
osteoporose
pós-menopausa
alendronato
vitamina D
recuperação óssea
title_short Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
title_full Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
title_fullStr Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
title_full_unstemmed Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
title_sort Alendronate sodium and vitamin D in postmenopausal osteoporosis: A systematic review
author Júnior, José Reginaldo Alves de Queiroz
author_facet Júnior, José Reginaldo Alves de Queiroz
Júnior, José Reginaldo Alves de Queiroz
Pereira, Jarson Pedro da Costa
Pires, Leonardo Lucas
Maia, Carina Scanoni
Pereira, Jarson Pedro da Costa
Pires, Leonardo Lucas
Maia, Carina Scanoni
author_role author
author2 Pereira, Jarson Pedro da Costa
Pires, Leonardo Lucas
Maia, Carina Scanoni
author2_role author
author
author
dc.contributor.author.fl_str_mv Júnior, José Reginaldo Alves de Queiroz
Pereira, Jarson Pedro da Costa
Pires, Leonardo Lucas
Maia, Carina Scanoni
dc.subject.por.fl_str_mv osteoporosis
postmenopause
alendronate
vitamin D
bone recovery
osteoporose
pós-menopausa
alendronato
vitamina D
recuperação óssea
topic osteoporosis
postmenopause
alendronate
vitamin D
bone recovery
osteoporose
pós-menopausa
alendronato
vitamina D
recuperação óssea
description Aim: to evaluate the effectiveness of using the combined therapy of sodium alendronate and vitamin D on bone metabolism in women undergoing postmenopausal osteoporosis. Methods: this is a systematic review. The studies included were Randomized Controlled Trials (RCT) indexed in the BVS, ISI Web of Science, PubMed, SciELO, ScienceDirect and Scopus Databases which compared the association of sodium alendronate and vitamin D to monotherapy of sodium alendronate. Results: a total of six RCT met the criteria to be included in this study, comprising a total of 4164 participants and their respective data. The studies evaluated different domains of bone metabolism, such as serum levels of vitamin D, parathyroid hormone, bone mineral density and bone turnover markers. Combination therapy produced significant improvement in bone metabolic markers. Conclusion: combined therapy of sodium alendronate with vitamin D promotes improved bone metabolism in women with postmenopausal osteoporosis.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/42267
10.15448/1980-6108.2022.1.42267
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/42267
identifier_str_mv 10.15448/1980-6108.2022.1.42267
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/42267/27614
dc.rights.driver.fl_str_mv Copyright (c) 2022 Scientia Medica
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Scientia Medica
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 32 No. 1 (2022): Single Volume; e42267
Scientia Medica; v. 32 n. 1 (2022): Volume Único; e42267
1980-6108
1806-5562
10.15448/1980-6108.2022.1
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
_version_ 1822181838219640832
dc.identifier.doi.none.fl_str_mv 10.15448/1980-6108.2022.1.42267

Registros relacionados