Angiogenic activity of sucupira (Pterodon emarginatus) oil

• Autor(a) principal: de Araújo, Lilhian Alves
• Data de Publicação: 2015
• Outros Autores: Assunção, Lazieny Avelina, Junior, Nelson Jorge da Silva, Lemes, Susy Ricardo, Reis, Paulo Roberto de Melo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Scientia Medica (Porto Alegre. Online)
• Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/20351
• topic: angiogenesis; membrane; chorioallantoic; Pterodon emarginatus; angiogênese; membrana corioalantóide; Pterodon emarginatus; Farmacognosia

Aims: To assess the angiogenic activity of sucupira (Pterodon emarginatus) oil, popularly used as an antirheumatic, analgesic, antimicrobial, and anti-inflammatory agent.Methods: The chick (Gallus domesticus) embryo chorioallantoic membrane (CAM) assay was used as an experimental model, incubated in a temperature- and humidity- controlled automatic incubator during the first five days. A circular hole was made at the wider base of the eggshell on the fifth day. After 13 days of incubation, filter paper discs containing sucupira oil and control substances were inserted into the  CAM. Subsequently, the CAMs were removed and submitted to analysis and quantification of the vascular network. The nonparametric Kruskal-Wallis test, followed by Dunn’s test, was used for the statistical analysis, and differences between the samples were set at a 5% level (p <0.05).Results: Sucupira oil at a concentration of 1g/mL induced a significant increase in the percentage area of the CAM vascular network of the embryonated chicken eggs, when compared with the neutral control (water) and inhibitory control (dexamethasone) groups (p <0.001). However, no significant difference in the induction of the CAM vascular network (p >0.05) was demonstrated between the oil and the positive control (Biocure) groups.Conclusions: The sucupira (Pterodon emarginatus) bean oil induced the formation of new blood vessels under the experimental conditions of the present study.