Avaliação audiológica em crianças com microcefalia pela síndrome congênita do Zika vírus

• Autor(a) principal: Rosa, Barbara Cristina da Silva
• Data de Publicação: 2019
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_SP
• Texto Completo: https://tede2.pucsp.br/handle/handle/22606
• topic: Audição; Perda auditiva; Microcefalia; Zika vírus; Hearing; Hearing loss; Microcephaly; Zika virus; CNPQ::CIENCIAS DA SAUDE::FONOAUDIOLOGIA

Introduction: An outbreak of children with microcephaly occurred in Brazil in 2015. This outbreak was associated with congenital Zika virus (ZIKV) syndrome. Objectives: This research was elaborated through two studies. Study 1 - Verify, by systematic review, the audiological findings of children with congenital Zika virus syndrome. Study 2 – Characterize the auditory function of children with microcephaly due to congenital Zika virus syndrome . Methods: Study 1 - This research is part of an integrated project of speech therapy alterations registered in PROSPERO. The systematic review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes, with no restriction regarding the year of publication and language, organized from the formulation of the clinical question "Does the child with congenital syndrome by ZIKV present audiological changes?''. The electronic databases consulted were PubMed, LILACS, Scopus, Web of Science, Sciense Direct, Embase, Open Gray and Open Thesis. Observational studies regarding children with microcephaly due to congenital ZIKV syndrome were included. Study 2 – Consisted of fifteen children with microcephaly due to the Zika virus congenital syndrome. Collection began in February 2017, ending in July 2018. All the guardians signed the free consent term for the performance of audiologic exams. The following exams were performed: otorhinolaryngological evaluation; audiological examinations: auditory behavior observation and visual reinforcement audiometry; Immittanciometry, Transient Stimulating Otoacoustic Emissions (TSOE), Brainstem Auditory Evoked Potential (BAEP) by airway and Steady-State Auditory Evoked Potential (SSAEP) with Narrow Band (NB) CE-Chirp stimulus (NB). Results: Study 1- A total of 348 titles were obtained, of which 21 were articles from Lilacs, 3 from Scielo, 16 from PubMed, 49 from Scoopus, 6 from Web of Science, 249 Science direct, none from Open Gray and 4 Open Thesis. Then, the exclusion of repeated titles and abstracts and application of the inclusion criteria were carried out. A total of 13 papers were read and evaluated for risk of bias by Joanna Briggs Institute, six of which were selected to be part of the scope of the research. Study 2 - During the study, four children were excluded from the final sample. Eleven children presented, in the behavioral evaluation, responses within the expected 20dB bilaterally regarding age for field calibrated tones, with two children being able to perform field audiometry with visual reinforcement with bilateral phone insertion. In relation to the TSOE, all children presented answers, in both ears, ten children presented type A tympanometry and one with type Ar. Regarding BAEP, the eight evaluated children had results within the normal range, with a minimum level of response at 20 dBHL bilaterally. In the SSAEP, six evaluated children had a minimum response level of 500Hz, 1kHz, 2kHz and 4kHz in 20dB bilaterally Conclusion: Study 1 - this study confirmed that children with congenital ZIKV syndrome may present hearing loss. Study 2 - The evaluated children did not present sensoryneural hearing loss