Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da PUC_SP |
Texto Completo: | https://tede2.pucsp.br/handle/handle/16826 |
Resumo: | The Chronic Mild Stress (CMS) is an experimental animal model of depression induced by the exposure of rats to a set of moderate and uncontrollable aversive stimuli in a long and uninterrupted period of time. The purpose of this study was to investigate the relationship between performance in variable interval schedule of behavior and exposure to the protocol of stress (daily consumption of food and water, changes in body weight, frequency of answers issued in each bar and the frequency of reinforcements obtained when submitted to the same scheme competitor). The study design was composed of three experimental conditions: test consumption and preferably liquid; sessions operating on schedule competitor VI 10 (water) VI 10 (sucrose) and protocol of stress (CMS). Six male rats were used. One subject was used to control weight, not involved in any of the three experimental conditions. Five subjects were submitted to the protocol of stress and tests of consumption and preference of liquids throughout the experiment. Two subjects were submitted to the working sessions (VI competitor VI) before and after CMS and two subjects were submitted to the working sessions before, during and after the CMS. The results were: 1) all subjects showed loss of body weight during the exposure to stressors. 2) The four subjects submitted to the working sessions showed recovery of body weight after the suspension of the protocol. 3) All subjects showed an increase in daily consumption of water and feed during the CMS, despite the loss of weight in this period. 4) Liquid consumption and the percentage of sucrose intake was higher during the CMS for the four subjects submitted to the working sessions, featuring a reduction in the last week of exposure to the protocol of stress. 5) All subjects expressed a greater number of responses in the bar corresponding to sucrose before exposure to CMS. Meanwhile, during and after CMS, a preference for water became outstanding. 6) The subjects received almost all of the planned reinforcements of both magnitudes (sucrose solution or pure water) in the three periods of assessment. We conclude that: 1) the loss of weight during the CMS seems to be related to the combination of aversive stimuli compound by the Protocol of stress and deprivation of water and food intermittent making up this protocol 2) the increase in the total consumption of liquids during the CMS appear to be related to the submission to the working sessions in variable interval before submission to the Protocol 3) the exposure of the subject to a scheme of variable interval, before CMS, slows the decline in the consumption of liquid and increases consumption of fluids during the CMS |
id |
PUC_SP-1_9aadbb05365ea6cea02e1c974a9c09c8 |
---|---|
oai_identifier_str |
oai:repositorio.pucsp.br:handle/16826 |
network_acronym_str |
PUC_SP-1 |
network_name_str |
Biblioteca Digital de Teses e Dissertações da PUC_SP |
repository_id_str |
|
spelling |
Banaco, Roberto Alveshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4126156Y1Cardoso, Luciana Roberta Donola2016-04-29T13:18:08Z2008-07-012008-05-14Cardoso, Luciana Roberta Donola. The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress. 2008. 106 f. Dissertação (Mestrado em Psicologia) - Pontifícia Universidade Católica de São Paulo, São Paulo, 2008.https://tede2.pucsp.br/handle/handle/16826The Chronic Mild Stress (CMS) is an experimental animal model of depression induced by the exposure of rats to a set of moderate and uncontrollable aversive stimuli in a long and uninterrupted period of time. The purpose of this study was to investigate the relationship between performance in variable interval schedule of behavior and exposure to the protocol of stress (daily consumption of food and water, changes in body weight, frequency of answers issued in each bar and the frequency of reinforcements obtained when submitted to the same scheme competitor). The study design was composed of three experimental conditions: test consumption and preferably liquid; sessions operating on schedule competitor VI 10 (water) VI 10 (sucrose) and protocol of stress (CMS). Six male rats were used. One subject was used to control weight, not involved in any of the three experimental conditions. Five subjects were submitted to the protocol of stress and tests of consumption and preference of liquids throughout the experiment. Two subjects were submitted to the working sessions (VI competitor VI) before and after CMS and two subjects were submitted to the working sessions before, during and after the CMS. The results were: 1) all subjects showed loss of body weight during the exposure to stressors. 2) The four subjects submitted to the working sessions showed recovery of body weight after the suspension of the protocol. 3) All subjects showed an increase in daily consumption of water and feed during the CMS, despite the loss of weight in this period. 4) Liquid consumption and the percentage of sucrose intake was higher during the CMS for the four subjects submitted to the working sessions, featuring a reduction in the last week of exposure to the protocol of stress. 5) All subjects expressed a greater number of responses in the bar corresponding to sucrose before exposure to CMS. Meanwhile, during and after CMS, a preference for water became outstanding. 6) The subjects received almost all of the planned reinforcements of both magnitudes (sucrose solution or pure water) in the three periods of assessment. We conclude that: 1) the loss of weight during the CMS seems to be related to the combination of aversive stimuli compound by the Protocol of stress and deprivation of water and food intermittent making up this protocol 2) the increase in the total consumption of liquids during the CMS appear to be related to the submission to the working sessions in variable interval before submission to the Protocol 3) the exposure of the subject to a scheme of variable interval, before CMS, slows the decline in the consumption of liquid and increases consumption of fluids during the CMSO Chronic Mild Stress (CMS) é um modelo animal experimental de depressão induzida por meio da exposição de ratos a um conjunto de estímulos aversivos moderados e incontroláveis, apresentados por um longo e ininterrupto período de tempo. O objetivo deste estudo foi investigar a possível relação entre o desempenho em esquema de intervalo variável e a exposição ao protocolo de estresse, quanto ao consumo diário de ração e água e as subseqüentes alterações no peso corporal; no consumo e na preferência de líquidos; na freqüência de respostas emitidas em cada barra e na freqüência de reforços obtidos nas mesmas quando submetidos ao esquema concorrente. O delineamento foi composto por três condições experimentais: teste de consumo e de preferência de líquidos; sessões operantes em esquema concorrente VI 10 (água) VI 10 (sacarose) e protocolo de estresse (CMS). Foram utilizados seis ratos machos, sendo que um sujeito foi utilizado para controle de peso, não submetido a nenhuma das três condições experimentais. Cinco sujeitos foram submetidos ao protocolo de estresse e aos testes de consumo e preferência de líquidos durante todo o experimento. Dois sujeitos foram submetidos às sessões operantes (concorrente VI VI) antes e depois do CMS e dois sujeitos foram submetidos às sessões operantes, antes, durante e depois do CMS. Os resultados obtidos foram: 1) todos os sujeitos apresentaram perda de peso corporal durante a exposição aos estressores. 2) Os quatro sujeitos submetidos às sessões operantes apresentaram recuperação do peso corporal após a suspensão do protocolo; 3) todos os sujeitos apresentaram aumento no consumo diário de água e ração durante o CMS, apesar da perda de peso neste período; 4) consumo total de líquidos e a porcentagem de sacarose ingerida foi maior durante o CMS para os quatro sujeitos submetidos as sessões operantes, apresentando uma redução na última semana de exposição ao protocolo de estresse; 5) todos os sujeitos emitiram um maior número de respostas na barra correspondente a sacarose antes da exposição ao CMS. Entretanto, durante e depois do CMS a preferência por água se tornou sobressalente; 6) os sujeitos obtiveram a quase totalidade de reforços programados de ambas as magnitudes (solução de sacarose ou água pura ) nos três períodos de avaliação. Conclui-se que: 1) a perda de peso corporal durante o CMS parece estar relacionada à combinação dos estímulos aversivos compostos pelo protocolo de estresse e à privação de água e ração intermitente que compõem este protocolo 2) o aumento no consumo total de líquidos durante o CMS parecem estar relacionados à submissão às sessões operantes em intervalo variável antes da submissão ao protocolo 3) a exposição dos sujeitos a um esquema de intervalo variável, antes do CMS, não só teria um efeito de retardar a diminuição no consumo de líquidos, como aumentar o consumo de líquidos durante o CMSapplication/pdfhttp://tede2.pucsp.br/tede/retrieve/35573/Luciana%20Roberta%20Donola%20Cardoso.pdf.jpgporPontifícia Universidade Católica de São PauloPrograma de Estudos Pós-Graduados em Psicologia Experimental: Análise do ComportamentoPUC-SPBRPsicologiaModelo experimentalChronic mild stressAvaliacao do comportamentoDepressaoExperimental modelChronic mild stressDepressionCNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTALEfeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stressThe effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stressinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_SPinstname:Pontifícia Universidade Católica de São Paulo (PUC-SP)instacron:PUC_SPTEXTLuciana Roberta Donola Cardoso.pdf.txtLuciana Roberta Donola Cardoso.pdf.txtExtracted texttext/plain145245https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/3/Luciana%20Roberta%20Donola%20Cardoso.pdf.txt6d1f780b9799908024ef4a89454ae335MD53ORIGINALLuciana Roberta Donola Cardoso.pdfapplication/pdf1323389https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/1/Luciana%20Roberta%20Donola%20Cardoso.pdf152237ce34951aabd58677f712755d06MD51THUMBNAILLuciana Roberta Donola Cardoso.pdf.jpgLuciana Roberta Donola Cardoso.pdf.jpgGenerated Thumbnailimage/jpeg1943https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/2/Luciana%20Roberta%20Donola%20Cardoso.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD52handle/168262022-04-27 18:55:07.194oai:repositorio.pucsp.br:handle/16826Biblioteca Digital de Teses e Dissertaçõeshttps://sapientia.pucsp.br/https://sapientia.pucsp.br/oai/requestbngkatende@pucsp.br||rapassi@pucsp.bropendoar:2022-04-27T21:55:07Biblioteca Digital de Teses e Dissertações da PUC_SP - Pontifícia Universidade Católica de São Paulo (PUC-SP)false |
dc.title.por.fl_str_mv |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress |
dc.title.alternative.eng.fl_str_mv |
The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress |
title |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress |
spellingShingle |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress Cardoso, Luciana Roberta Donola Modelo experimental Chronic mild stress Avaliacao do comportamento Depressao Experimental model Chronic mild stress Depression CNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTAL |
title_short |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress |
title_full |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress |
title_fullStr |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress |
title_full_unstemmed |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress |
title_sort |
Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress |
author |
Cardoso, Luciana Roberta Donola |
author_facet |
Cardoso, Luciana Roberta Donola |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Banaco, Roberto Alves |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4126156Y1 |
dc.contributor.author.fl_str_mv |
Cardoso, Luciana Roberta Donola |
contributor_str_mv |
Banaco, Roberto Alves |
dc.subject.por.fl_str_mv |
Modelo experimental Chronic mild stress Avaliacao do comportamento Depressao |
topic |
Modelo experimental Chronic mild stress Avaliacao do comportamento Depressao Experimental model Chronic mild stress Depression CNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTAL |
dc.subject.eng.fl_str_mv |
Experimental model Chronic mild stress Depression |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTAL |
description |
The Chronic Mild Stress (CMS) is an experimental animal model of depression induced by the exposure of rats to a set of moderate and uncontrollable aversive stimuli in a long and uninterrupted period of time. The purpose of this study was to investigate the relationship between performance in variable interval schedule of behavior and exposure to the protocol of stress (daily consumption of food and water, changes in body weight, frequency of answers issued in each bar and the frequency of reinforcements obtained when submitted to the same scheme competitor). The study design was composed of three experimental conditions: test consumption and preferably liquid; sessions operating on schedule competitor VI 10 (water) VI 10 (sucrose) and protocol of stress (CMS). Six male rats were used. One subject was used to control weight, not involved in any of the three experimental conditions. Five subjects were submitted to the protocol of stress and tests of consumption and preference of liquids throughout the experiment. Two subjects were submitted to the working sessions (VI competitor VI) before and after CMS and two subjects were submitted to the working sessions before, during and after the CMS. The results were: 1) all subjects showed loss of body weight during the exposure to stressors. 2) The four subjects submitted to the working sessions showed recovery of body weight after the suspension of the protocol. 3) All subjects showed an increase in daily consumption of water and feed during the CMS, despite the loss of weight in this period. 4) Liquid consumption and the percentage of sucrose intake was higher during the CMS for the four subjects submitted to the working sessions, featuring a reduction in the last week of exposure to the protocol of stress. 5) All subjects expressed a greater number of responses in the bar corresponding to sucrose before exposure to CMS. Meanwhile, during and after CMS, a preference for water became outstanding. 6) The subjects received almost all of the planned reinforcements of both magnitudes (sucrose solution or pure water) in the three periods of assessment. We conclude that: 1) the loss of weight during the CMS seems to be related to the combination of aversive stimuli compound by the Protocol of stress and deprivation of water and food intermittent making up this protocol 2) the increase in the total consumption of liquids during the CMS appear to be related to the submission to the working sessions in variable interval before submission to the Protocol 3) the exposure of the subject to a scheme of variable interval, before CMS, slows the decline in the consumption of liquid and increases consumption of fluids during the CMS |
publishDate |
2008 |
dc.date.available.fl_str_mv |
2008-07-01 |
dc.date.issued.fl_str_mv |
2008-05-14 |
dc.date.accessioned.fl_str_mv |
2016-04-29T13:18:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Cardoso, Luciana Roberta Donola. The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress. 2008. 106 f. Dissertação (Mestrado em Psicologia) - Pontifícia Universidade Católica de São Paulo, São Paulo, 2008. |
dc.identifier.uri.fl_str_mv |
https://tede2.pucsp.br/handle/handle/16826 |
identifier_str_mv |
Cardoso, Luciana Roberta Donola. The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress. 2008. 106 f. Dissertação (Mestrado em Psicologia) - Pontifícia Universidade Católica de São Paulo, São Paulo, 2008. |
url |
https://tede2.pucsp.br/handle/handle/16826 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pontifícia Universidade Católica de São Paulo |
dc.publisher.program.fl_str_mv |
Programa de Estudos Pós-Graduados em Psicologia Experimental: Análise do Comportamento |
dc.publisher.initials.fl_str_mv |
PUC-SP |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Psicologia |
publisher.none.fl_str_mv |
Pontifícia Universidade Católica de São Paulo |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da PUC_SP instname:Pontifícia Universidade Católica de São Paulo (PUC-SP) instacron:PUC_SP |
instname_str |
Pontifícia Universidade Católica de São Paulo (PUC-SP) |
instacron_str |
PUC_SP |
institution |
PUC_SP |
reponame_str |
Biblioteca Digital de Teses e Dissertações da PUC_SP |
collection |
Biblioteca Digital de Teses e Dissertações da PUC_SP |
bitstream.url.fl_str_mv |
https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/3/Luciana%20Roberta%20Donola%20Cardoso.pdf.txt https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/1/Luciana%20Roberta%20Donola%20Cardoso.pdf https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/2/Luciana%20Roberta%20Donola%20Cardoso.pdf.jpg |
bitstream.checksum.fl_str_mv |
6d1f780b9799908024ef4a89454ae335 152237ce34951aabd58677f712755d06 cc73c4c239a4c332d642ba1e7c7a9fb2 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da PUC_SP - Pontifícia Universidade Católica de São Paulo (PUC-SP) |
repository.mail.fl_str_mv |
bngkatende@pucsp.br||rapassi@pucsp.br |
_version_ |
1809277867191697408 |