Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress

Detalhes bibliográficos
Autor(a) principal: Cardoso, Luciana Roberta Donola
Data de Publicação: 2008
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_SP
Texto Completo: https://tede2.pucsp.br/handle/handle/16826
Resumo: The Chronic Mild Stress (CMS) is an experimental animal model of depression induced by the exposure of rats to a set of moderate and uncontrollable aversive stimuli in a long and uninterrupted period of time. The purpose of this study was to investigate the relationship between performance in variable interval schedule of behavior and exposure to the protocol of stress (daily consumption of food and water, changes in body weight, frequency of answers issued in each bar and the frequency of reinforcements obtained when submitted to the same scheme competitor). The study design was composed of three experimental conditions: test consumption and preferably liquid; sessions operating on schedule competitor VI 10 (water) VI 10 (sucrose) and protocol of stress (CMS). Six male rats were used. One subject was used to control weight, not involved in any of the three experimental conditions. Five subjects were submitted to the protocol of stress and tests of consumption and preference of liquids throughout the experiment. Two subjects were submitted to the working sessions (VI competitor VI) before and after CMS and two subjects were submitted to the working sessions before, during and after the CMS. The results were: 1) all subjects showed loss of body weight during the exposure to stressors. 2) The four subjects submitted to the working sessions showed recovery of body weight after the suspension of the protocol. 3) All subjects showed an increase in daily consumption of water and feed during the CMS, despite the loss of weight in this period. 4) Liquid consumption and the percentage of sucrose intake was higher during the CMS for the four subjects submitted to the working sessions, featuring a reduction in the last week of exposure to the protocol of stress. 5) All subjects expressed a greater number of responses in the bar corresponding to sucrose before exposure to CMS. Meanwhile, during and after CMS, a preference for water became outstanding. 6) The subjects received almost all of the planned reinforcements of both magnitudes (sucrose solution or pure water) in the three periods of assessment. We conclude that: 1) the loss of weight during the CMS seems to be related to the combination of aversive stimuli compound by the Protocol of stress and deprivation of water and food intermittent making up this protocol 2) the increase in the total consumption of liquids during the CMS appear to be related to the submission to the working sessions in variable interval before submission to the Protocol 3) the exposure of the subject to a scheme of variable interval, before CMS, slows the decline in the consumption of liquid and increases consumption of fluids during the CMS
id PUC_SP-1_9aadbb05365ea6cea02e1c974a9c09c8
oai_identifier_str oai:repositorio.pucsp.br:handle/16826
network_acronym_str PUC_SP-1
network_name_str Biblioteca Digital de Teses e Dissertações da PUC_SP
repository_id_str
spelling Banaco, Roberto Alveshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4126156Y1Cardoso, Luciana Roberta Donola2016-04-29T13:18:08Z2008-07-012008-05-14Cardoso, Luciana Roberta Donola. The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress. 2008. 106 f. Dissertação (Mestrado em Psicologia) - Pontifícia Universidade Católica de São Paulo, São Paulo, 2008.https://tede2.pucsp.br/handle/handle/16826The Chronic Mild Stress (CMS) is an experimental animal model of depression induced by the exposure of rats to a set of moderate and uncontrollable aversive stimuli in a long and uninterrupted period of time. The purpose of this study was to investigate the relationship between performance in variable interval schedule of behavior and exposure to the protocol of stress (daily consumption of food and water, changes in body weight, frequency of answers issued in each bar and the frequency of reinforcements obtained when submitted to the same scheme competitor). The study design was composed of three experimental conditions: test consumption and preferably liquid; sessions operating on schedule competitor VI 10 (water) VI 10 (sucrose) and protocol of stress (CMS). Six male rats were used. One subject was used to control weight, not involved in any of the three experimental conditions. Five subjects were submitted to the protocol of stress and tests of consumption and preference of liquids throughout the experiment. Two subjects were submitted to the working sessions (VI competitor VI) before and after CMS and two subjects were submitted to the working sessions before, during and after the CMS. The results were: 1) all subjects showed loss of body weight during the exposure to stressors. 2) The four subjects submitted to the working sessions showed recovery of body weight after the suspension of the protocol. 3) All subjects showed an increase in daily consumption of water and feed during the CMS, despite the loss of weight in this period. 4) Liquid consumption and the percentage of sucrose intake was higher during the CMS for the four subjects submitted to the working sessions, featuring a reduction in the last week of exposure to the protocol of stress. 5) All subjects expressed a greater number of responses in the bar corresponding to sucrose before exposure to CMS. Meanwhile, during and after CMS, a preference for water became outstanding. 6) The subjects received almost all of the planned reinforcements of both magnitudes (sucrose solution or pure water) in the three periods of assessment. We conclude that: 1) the loss of weight during the CMS seems to be related to the combination of aversive stimuli compound by the Protocol of stress and deprivation of water and food intermittent making up this protocol 2) the increase in the total consumption of liquids during the CMS appear to be related to the submission to the working sessions in variable interval before submission to the Protocol 3) the exposure of the subject to a scheme of variable interval, before CMS, slows the decline in the consumption of liquid and increases consumption of fluids during the CMSO Chronic Mild Stress (CMS) é um modelo animal experimental de depressão induzida por meio da exposição de ratos a um conjunto de estímulos aversivos moderados e incontroláveis, apresentados por um longo e ininterrupto período de tempo. O objetivo deste estudo foi investigar a possível relação entre o desempenho em esquema de intervalo variável e a exposição ao protocolo de estresse, quanto ao consumo diário de ração e água e as subseqüentes alterações no peso corporal; no consumo e na preferência de líquidos; na freqüência de respostas emitidas em cada barra e na freqüência de reforços obtidos nas mesmas quando submetidos ao esquema concorrente. O delineamento foi composto por três condições experimentais: teste de consumo e de preferência de líquidos; sessões operantes em esquema concorrente VI 10 (água) VI 10 (sacarose) e protocolo de estresse (CMS). Foram utilizados seis ratos machos, sendo que um sujeito foi utilizado para controle de peso, não submetido a nenhuma das três condições experimentais. Cinco sujeitos foram submetidos ao protocolo de estresse e aos testes de consumo e preferência de líquidos durante todo o experimento. Dois sujeitos foram submetidos às sessões operantes (concorrente VI VI) antes e depois do CMS e dois sujeitos foram submetidos às sessões operantes, antes, durante e depois do CMS. Os resultados obtidos foram: 1) todos os sujeitos apresentaram perda de peso corporal durante a exposição aos estressores. 2) Os quatro sujeitos submetidos às sessões operantes apresentaram recuperação do peso corporal após a suspensão do protocolo; 3) todos os sujeitos apresentaram aumento no consumo diário de água e ração durante o CMS, apesar da perda de peso neste período; 4) consumo total de líquidos e a porcentagem de sacarose ingerida foi maior durante o CMS para os quatro sujeitos submetidos as sessões operantes, apresentando uma redução na última semana de exposição ao protocolo de estresse; 5) todos os sujeitos emitiram um maior número de respostas na barra correspondente a sacarose antes da exposição ao CMS. Entretanto, durante e depois do CMS a preferência por água se tornou sobressalente; 6) os sujeitos obtiveram a quase totalidade de reforços programados de ambas as magnitudes (solução de sacarose ou água pura ) nos três períodos de avaliação. Conclui-se que: 1) a perda de peso corporal durante o CMS parece estar relacionada à combinação dos estímulos aversivos compostos pelo protocolo de estresse e à privação de água e ração intermitente que compõem este protocolo 2) o aumento no consumo total de líquidos durante o CMS parecem estar relacionados à submissão às sessões operantes em intervalo variável antes da submissão ao protocolo 3) a exposição dos sujeitos a um esquema de intervalo variável, antes do CMS, não só teria um efeito de retardar a diminuição no consumo de líquidos, como aumentar o consumo de líquidos durante o CMSapplication/pdfhttp://tede2.pucsp.br/tede/retrieve/35573/Luciana%20Roberta%20Donola%20Cardoso.pdf.jpgporPontifícia Universidade Católica de São PauloPrograma de Estudos Pós-Graduados em Psicologia Experimental: Análise do ComportamentoPUC-SPBRPsicologiaModelo experimentalChronic mild stressAvaliacao do comportamentoDepressaoExperimental modelChronic mild stressDepressionCNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTALEfeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stressThe effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stressinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_SPinstname:Pontifícia Universidade Católica de São Paulo (PUC-SP)instacron:PUC_SPTEXTLuciana Roberta Donola Cardoso.pdf.txtLuciana Roberta Donola Cardoso.pdf.txtExtracted texttext/plain145245https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/3/Luciana%20Roberta%20Donola%20Cardoso.pdf.txt6d1f780b9799908024ef4a89454ae335MD53ORIGINALLuciana Roberta Donola Cardoso.pdfapplication/pdf1323389https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/1/Luciana%20Roberta%20Donola%20Cardoso.pdf152237ce34951aabd58677f712755d06MD51THUMBNAILLuciana Roberta Donola Cardoso.pdf.jpgLuciana Roberta Donola Cardoso.pdf.jpgGenerated Thumbnailimage/jpeg1943https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/2/Luciana%20Roberta%20Donola%20Cardoso.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD52handle/168262022-04-27 18:55:07.194oai:repositorio.pucsp.br:handle/16826Biblioteca Digital de Teses e Dissertaçõeshttps://sapientia.pucsp.br/https://sapientia.pucsp.br/oai/requestbngkatende@pucsp.br||rapassi@pucsp.bropendoar:2022-04-27T21:55:07Biblioteca Digital de Teses e Dissertações da PUC_SP - Pontifícia Universidade Católica de São Paulo (PUC-SP)false
dc.title.por.fl_str_mv Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
dc.title.alternative.eng.fl_str_mv The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress
title Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
spellingShingle Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
Cardoso, Luciana Roberta Donola
Modelo experimental
Chronic mild stress
Avaliacao do comportamento
Depressao
Experimental model
Chronic mild stress
Depression
CNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTAL
title_short Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
title_full Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
title_fullStr Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
title_full_unstemmed Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
title_sort Efeitos do esquema de intervalo variável na preferência e no consumo de líquidos apresentados por ratos submetidos ao chronic mild stress
author Cardoso, Luciana Roberta Donola
author_facet Cardoso, Luciana Roberta Donola
author_role author
dc.contributor.advisor1.fl_str_mv Banaco, Roberto Alves
dc.contributor.authorLattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4126156Y1
dc.contributor.author.fl_str_mv Cardoso, Luciana Roberta Donola
contributor_str_mv Banaco, Roberto Alves
dc.subject.por.fl_str_mv Modelo experimental
Chronic mild stress
Avaliacao do comportamento
Depressao
topic Modelo experimental
Chronic mild stress
Avaliacao do comportamento
Depressao
Experimental model
Chronic mild stress
Depression
CNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTAL
dc.subject.eng.fl_str_mv Experimental model
Chronic mild stress
Depression
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS HUMANAS::PSICOLOGIA::PSICOLOGIA EXPERIMENTAL
description The Chronic Mild Stress (CMS) is an experimental animal model of depression induced by the exposure of rats to a set of moderate and uncontrollable aversive stimuli in a long and uninterrupted period of time. The purpose of this study was to investigate the relationship between performance in variable interval schedule of behavior and exposure to the protocol of stress (daily consumption of food and water, changes in body weight, frequency of answers issued in each bar and the frequency of reinforcements obtained when submitted to the same scheme competitor). The study design was composed of three experimental conditions: test consumption and preferably liquid; sessions operating on schedule competitor VI 10 (water) VI 10 (sucrose) and protocol of stress (CMS). Six male rats were used. One subject was used to control weight, not involved in any of the three experimental conditions. Five subjects were submitted to the protocol of stress and tests of consumption and preference of liquids throughout the experiment. Two subjects were submitted to the working sessions (VI competitor VI) before and after CMS and two subjects were submitted to the working sessions before, during and after the CMS. The results were: 1) all subjects showed loss of body weight during the exposure to stressors. 2) The four subjects submitted to the working sessions showed recovery of body weight after the suspension of the protocol. 3) All subjects showed an increase in daily consumption of water and feed during the CMS, despite the loss of weight in this period. 4) Liquid consumption and the percentage of sucrose intake was higher during the CMS for the four subjects submitted to the working sessions, featuring a reduction in the last week of exposure to the protocol of stress. 5) All subjects expressed a greater number of responses in the bar corresponding to sucrose before exposure to CMS. Meanwhile, during and after CMS, a preference for water became outstanding. 6) The subjects received almost all of the planned reinforcements of both magnitudes (sucrose solution or pure water) in the three periods of assessment. We conclude that: 1) the loss of weight during the CMS seems to be related to the combination of aversive stimuli compound by the Protocol of stress and deprivation of water and food intermittent making up this protocol 2) the increase in the total consumption of liquids during the CMS appear to be related to the submission to the working sessions in variable interval before submission to the Protocol 3) the exposure of the subject to a scheme of variable interval, before CMS, slows the decline in the consumption of liquid and increases consumption of fluids during the CMS
publishDate 2008
dc.date.available.fl_str_mv 2008-07-01
dc.date.issued.fl_str_mv 2008-05-14
dc.date.accessioned.fl_str_mv 2016-04-29T13:18:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv Cardoso, Luciana Roberta Donola. The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress. 2008. 106 f. Dissertação (Mestrado em Psicologia) - Pontifícia Universidade Católica de São Paulo, São Paulo, 2008.
dc.identifier.uri.fl_str_mv https://tede2.pucsp.br/handle/handle/16826
identifier_str_mv Cardoso, Luciana Roberta Donola. The effects of variable interval schedule on preference and liquid consumption by rats subjected to chronic mild stress. 2008. 106 f. Dissertação (Mestrado em Psicologia) - Pontifícia Universidade Católica de São Paulo, São Paulo, 2008.
url https://tede2.pucsp.br/handle/handle/16826
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pontifícia Universidade Católica de São Paulo
dc.publisher.program.fl_str_mv Programa de Estudos Pós-Graduados em Psicologia Experimental: Análise do Comportamento
dc.publisher.initials.fl_str_mv PUC-SP
dc.publisher.country.fl_str_mv BR
dc.publisher.department.fl_str_mv Psicologia
publisher.none.fl_str_mv Pontifícia Universidade Católica de São Paulo
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da PUC_SP
instname:Pontifícia Universidade Católica de São Paulo (PUC-SP)
instacron:PUC_SP
instname_str Pontifícia Universidade Católica de São Paulo (PUC-SP)
instacron_str PUC_SP
institution PUC_SP
reponame_str Biblioteca Digital de Teses e Dissertações da PUC_SP
collection Biblioteca Digital de Teses e Dissertações da PUC_SP
bitstream.url.fl_str_mv https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/3/Luciana%20Roberta%20Donola%20Cardoso.pdf.txt
https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/1/Luciana%20Roberta%20Donola%20Cardoso.pdf
https://repositorio.pucsp.br/xmlui/bitstream/handle/16826/2/Luciana%20Roberta%20Donola%20Cardoso.pdf.jpg
bitstream.checksum.fl_str_mv 6d1f780b9799908024ef4a89454ae335
152237ce34951aabd58677f712755d06
cc73c4c239a4c332d642ba1e7c7a9fb2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da PUC_SP - Pontifícia Universidade Católica de São Paulo (PUC-SP)
repository.mail.fl_str_mv bngkatende@pucsp.br||rapassi@pucsp.br
_version_ 1809277867191697408