Fluência verbal em pacientes com doença de Parkinson tratados com a técnica de estimulação cerebral profunda no núcleo subtalâmico bilateral

• Autor(a) principal: Fagundes, Valéria de Carvalho
• Data de Publicação: 2016
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/6738
• topic: DOENÇA DE PARKINSON; COGNIÇÃO; QUALIDADE DE VIDA; GERONTOLOGIA; MEDICINA; CIENCIAS DA SAUDE::MEDICINA

The Deep Brain Stimulation (DBS) for the treatment of Parkinson's disease (PD) involves the implantation of four microelectrodes in the subthalamic nucleus (STN). Although usually safe from a cognitive point of view, the SNT DBS has been linked to a decrease in verbal fluency (VF) in nearly all studies comparing preoperative to postoperative period. The decline can be attributed to surgical effects, but the real contributions of the stimulation frequency effects are not known. This research aims to investigate the impact of the frequency of SNT DBS in the performance of VF in patients with PD, comparing the VF and the motor performance at low frequency (60 Hz) and high-frequency (130 Hz), assessing the quality of life and correlating the demographic factors such as age and educational level and reading and writing habits with VF. It is a randomized double-blind experimental study. The initial sample consisted of 25 individuals, but 5 were excluded for not meeting the inclusion criteria. Thus, 20 subjects were included in the sample, from 30 to 75 years of age (56.7 ± 10.7), with average schooling 10.1 (± 5.2), and 16 were males and 4 females. Participants were evaluated with phonetic and categorical VF tasks, motor scale (UPDRS III), quality of life questionnaire (PDQ-39) and reading and writing habits. The evaluation of motor and VF was assessed after one hour from the frequency setting for high (130 Hz) and low (60 Hz), the frequency adjustment order being randomized. Patients with PD who underwent SNT DBS showed a decrease in phonemic VF in high frequency. There was no correlation regarding age and educational level of participants when compared to VF. The high frequency (130 Hz) of the SNT DBS caused a decline in VF and there was no correlation with socio-demographic factors such as age and educational level.