Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da PUC_RS |
Texto Completo: | http://tede2.pucrs.br/tede2/handle/tede/6777 |
Resumo: | Metabolic syndrome is a public health problem due to its high prevalence, once it is characterized by a set of risk factors that, when associated, predisposes to the development of atherosclerosis and its complications (acute myocardial infarction and stroke) and diabetes mellitus type 2. These risk factors are interconnected by biochemical, clinical, metabolic and inflammatory reactions. Chronic inflammation is closely related to the adipose tissue, predisposing to an induction of various cytokines which constitutes an important link between insulin resistance and endothelial dysfunction, precursor of atherosclerosis. The aim of this study was to evaluate the profile of cytokines in patients with metabolic syndrome and severe coronary artery disease. This was a controlled cross-sectional study with descriptive-analytic approach in patients treated at the Cardiometabolic Clinic of the Hospital São Lucas / PUCRS, Porto Alegre, Brazil. The sample was composed of three independent groups. Group 1 (n = 30) was composed of patients diagnosed with metabolic syndrome without significant coronary artery disease; group 2 (n = 30) was composed of patients with metabolic syndrome but with severe coronary artery disease; and group 3, control group, comprised healthy individuals. The activities of pro and anti-inflammatory cytokines, the oxidative stress, the anthropometric data and the biochemical data were evaluated. Levels of pro-inflammatory interleukins (TNF-α, IL-6, IL-12) were significantly higher in group 1, and so were IL-10 (anti-inflammatory) levels in this group. The main finding of this study showed that high IL-10 levels in patients with metabolic syndrome are associated with lower incidence of severe coronary artery disease, suggesting a protective effect through its anti-inflammatory activity, even in the presence of increased levels of other pro-inflammatory cytokines. Low IL-10 levels are associated with higher incidence of severe coronary artery disease in this population. |
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Bodanese, Luiz Carlos183.406.360-49http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4728609U5Oliveira, Jarbas Rodrigues dehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781448U1908.732.110-49http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4756287E9Barcelos, Ana Letícia Vargas2016-06-22T18:54:21Z2016-03-30http://tede2.pucrs.br/tede2/handle/tede/6777Metabolic syndrome is a public health problem due to its high prevalence, once it is characterized by a set of risk factors that, when associated, predisposes to the development of atherosclerosis and its complications (acute myocardial infarction and stroke) and diabetes mellitus type 2. These risk factors are interconnected by biochemical, clinical, metabolic and inflammatory reactions. Chronic inflammation is closely related to the adipose tissue, predisposing to an induction of various cytokines which constitutes an important link between insulin resistance and endothelial dysfunction, precursor of atherosclerosis. The aim of this study was to evaluate the profile of cytokines in patients with metabolic syndrome and severe coronary artery disease. This was a controlled cross-sectional study with descriptive-analytic approach in patients treated at the Cardiometabolic Clinic of the Hospital São Lucas / PUCRS, Porto Alegre, Brazil. The sample was composed of three independent groups. Group 1 (n = 30) was composed of patients diagnosed with metabolic syndrome without significant coronary artery disease; group 2 (n = 30) was composed of patients with metabolic syndrome but with severe coronary artery disease; and group 3, control group, comprised healthy individuals. The activities of pro and anti-inflammatory cytokines, the oxidative stress, the anthropometric data and the biochemical data were evaluated. Levels of pro-inflammatory interleukins (TNF-α, IL-6, IL-12) were significantly higher in group 1, and so were IL-10 (anti-inflammatory) levels in this group. The main finding of this study showed that high IL-10 levels in patients with metabolic syndrome are associated with lower incidence of severe coronary artery disease, suggesting a protective effect through its anti-inflammatory activity, even in the presence of increased levels of other pro-inflammatory cytokines. Low IL-10 levels are associated with higher incidence of severe coronary artery disease in this population.A Síndrome Metabólica é um problema de saúde pública devido a sua alta prevalência, pois se caracteriza por um conjunto de fatores de risco, que associados predispõe o desenvolvimento de doença aterosclerótica e suas complicações (infarto agudo do miocárdio e acidente vascular cerebral) e Diabetes mellitus tipo 2. Esses fatores de risco estão interligados por aspectos bioquímicos, clínicos, metabólicos e por reações inflamatórias. A inflamação crônica apresenta estreita relação com o tecido adiposo, predispondo a uma indução de diversas citocinas as quais constituem um elo importante entre a resistência à insulina e a disfunção endotelial, precursora da aterosclerose. O objetivo do presente estudo é avaliar o perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave. Foi realizado um estudo observacional do tipo transversal controlado com abordagem descritivo-analítica em pacientes atendidos no Ambulatório Cardiometabólico do Hospital São Lucas/PUCRS, Porto Alegre, Brasil. A amostra foi composta por três grupos independentes. No grupo 1 (n=30) foram incluídos pacientes com diagnóstico de síndrome metabólica sem doença arterial coronariana grave; no grupo 2 (n=30) pacientes com síndrome metabólica porém com doença arterial coronariana grave e no grupo 3, grupo controle, foram incluídos indivíduos saudáveis. Foram avaliadas as atividades das citocinas pró e anti-inflamatórias, o estresse oxidativo, dados antropométricos e dados bioquímicos. Níveis de interleucinas pró-inflamatórias como TNF-α, IL-6, IL-12 apresentaram-se níveis significativamente mais elevados no grupo 1, bem como a IL-10 (anti-inflamatória). O principal achado deste estudo demonstrou que altos níveis de IL-10 em pacientes com síndrome metabólica estão associados a menor incidência de doença arterial coronariana grave. Isto sugere um efeito protetor através de sua atividade anti-inflamatória, mesmo na presença de níveis aumentados de outras citocinas pró-inflamatórias. Baixos níveis de IL-10 estão associados a maior ocorrência de doença arterial coronariana grave nessa população.Submitted by Setor de Tratamento da Informação - BC/PUCRS (tede2@pucrs.br) on 2016-06-22T18:54:20Z No. of bitstreams: 1 TES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf: 1508088 bytes, checksum: ebb1a61bcd13d9f1f26191fbf2f2434e (MD5)Made available in DSpace on 2016-06-22T18:54:21Z (GMT). No. of bitstreams: 1 TES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf: 1508088 bytes, checksum: ebb1a61bcd13d9f1f26191fbf2f2434e (MD5) Previous issue date: 2016-03-30application/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/165446/TES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf.jpgporPontifícia Universidade Católica do Rio Grande do SulPrograma de Pós-Graduação em Medicina e Ciências da SaúdePUCRSBrasilFaculdade de MedicinaCITOCINASSÍNDROME METABÓLICAINTERLEUCINASDOENÇA DA ARTÉRIA CORONARIANACLÍNICA MÉDICAMEDICINACIENCIAS DA SAUDE::MEDICINAPerfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana graveinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis7620745074616285884600600600-8624664729441623247-969369452308786627info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILTES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf.jpgTES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf.jpgimage/jpeg3170http://tede2.pucrs.br/tede2/bitstream/tede/6777/5/TES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf.jpg913b5d79c77318bb693528edf8456a94MD55TEXTTES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf.txtTES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf.txttext/plain156154http://tede2.pucrs.br/tede2/bitstream/tede/6777/4/TES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdf.txt9480b682a8aa3d963b94ba054496cd1fMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-8610http://tede2.pucrs.br/tede2/bitstream/tede/6777/3/license.txt5a9d6006225b368ef605ba16b4f6d1beMD53ORIGINALTES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdfTES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdfapplication/pdf1508088http://tede2.pucrs.br/tede2/bitstream/tede/6777/2/TES_ANA_LETICIA_VARGAS_BARCELOS_COMPLETO.pdfebb1a61bcd13d9f1f26191fbf2f2434eMD52tede/67772016-06-22 20:00:34.182oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2016-06-22T23:00:34Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave |
title |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave |
spellingShingle |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave Barcelos, Ana Letícia Vargas CITOCINAS SÍNDROME METABÓLICA INTERLEUCINAS DOENÇA DA ARTÉRIA CORONARIANA CLÍNICA MÉDICA MEDICINA CIENCIAS DA SAUDE::MEDICINA |
title_short |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave |
title_full |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave |
title_fullStr |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave |
title_full_unstemmed |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave |
title_sort |
Perfil das citocinas em pacientes com síndrome metabólica e doença arterial coronariana grave |
author |
Barcelos, Ana Letícia Vargas |
author_facet |
Barcelos, Ana Letícia Vargas |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Bodanese, Luiz Carlos |
dc.contributor.advisor1ID.fl_str_mv |
183.406.360-49 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4728609U5 |
dc.contributor.advisor-co1.fl_str_mv |
Oliveira, Jarbas Rodrigues de |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781448U1 |
dc.contributor.authorID.fl_str_mv |
908.732.110-49 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4756287E9 |
dc.contributor.author.fl_str_mv |
Barcelos, Ana Letícia Vargas |
contributor_str_mv |
Bodanese, Luiz Carlos Oliveira, Jarbas Rodrigues de |
dc.subject.por.fl_str_mv |
CITOCINAS SÍNDROME METABÓLICA INTERLEUCINAS DOENÇA DA ARTÉRIA CORONARIANA CLÍNICA MÉDICA MEDICINA |
topic |
CITOCINAS SÍNDROME METABÓLICA INTERLEUCINAS DOENÇA DA ARTÉRIA CORONARIANA CLÍNICA MÉDICA MEDICINA CIENCIAS DA SAUDE::MEDICINA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Metabolic syndrome is a public health problem due to its high prevalence, once it is characterized by a set of risk factors that, when associated, predisposes to the development of atherosclerosis and its complications (acute myocardial infarction and stroke) and diabetes mellitus type 2. These risk factors are interconnected by biochemical, clinical, metabolic and inflammatory reactions. Chronic inflammation is closely related to the adipose tissue, predisposing to an induction of various cytokines which constitutes an important link between insulin resistance and endothelial dysfunction, precursor of atherosclerosis. The aim of this study was to evaluate the profile of cytokines in patients with metabolic syndrome and severe coronary artery disease. This was a controlled cross-sectional study with descriptive-analytic approach in patients treated at the Cardiometabolic Clinic of the Hospital São Lucas / PUCRS, Porto Alegre, Brazil. The sample was composed of three independent groups. Group 1 (n = 30) was composed of patients diagnosed with metabolic syndrome without significant coronary artery disease; group 2 (n = 30) was composed of patients with metabolic syndrome but with severe coronary artery disease; and group 3, control group, comprised healthy individuals. The activities of pro and anti-inflammatory cytokines, the oxidative stress, the anthropometric data and the biochemical data were evaluated. Levels of pro-inflammatory interleukins (TNF-α, IL-6, IL-12) were significantly higher in group 1, and so were IL-10 (anti-inflammatory) levels in this group. The main finding of this study showed that high IL-10 levels in patients with metabolic syndrome are associated with lower incidence of severe coronary artery disease, suggesting a protective effect through its anti-inflammatory activity, even in the presence of increased levels of other pro-inflammatory cytokines. Low IL-10 levels are associated with higher incidence of severe coronary artery disease in this population. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-06-22T18:54:21Z |
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2016-03-30 |
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http://tede2.pucrs.br/tede2/handle/tede/6777 |
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http://tede2.pucrs.br/tede2/handle/tede/6777 |
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por |
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por |
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7620745074616285884 |
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600 600 600 |
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Pontifícia Universidade Católica do Rio Grande do Sul |
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Programa de Pós-Graduação em Medicina e Ciências da Saúde |
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PUCRS |
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Faculdade de Medicina |
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