Network meta-análise do uso de probióticos na prevenção de infecções respiratórias em crianças e adolescentes

• Autor(a) principal: Amaral , Marina Azambuja
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/5969
• topic: MEDICINA; PEDIATRIA; CLÍNICA MÉDICA; INFECÇÕES RESPIRATÓRIAS; PROBIÓTICOS; CIENCIAS DA SAUDE::MEDICINA

CONTEXT : Probiotics have emerged as a promising intervention for the prevention of respiratory infections in children, according to several randomized controlled trials.OBJECTIVE : Critically assess the effect of probiotics on prevention of respiratory tract infections in children and adolescents.METHODS: Data Sources: Searches were conducted on February 24, 2014 in the following databases: MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. The following combinations of terms were used: “respiratory tract infections” AND probiotics. Study selection: Randomized clinical trials assessing the effect of probiotics on respiratory tract infections (RTIs) in children and adolescents were included. Studies involving children with chronic diseases or other pre-existing comorbidities and those that did not specifying the type of probiotic were excluded. Data extraction and Synthesis: Two reviewers, working independently, screened all titles and abstracts to identify studies that met the eligibility criteria. Pairwise and network analyses were performed to identify the effects of probiotics on respiratory infections. Main outcomes and Measures: Main and secondary outcomes were respiratory tract infections and adverse effects, respectively.RESULTS : Twenty-one trials with 6.603 participants were included. Direct comparison analysis suggested that Lactobacillus casei rhamnosus (LCA) was the only effective probiotic to the rate of respiratory infections compared to placebo (RR0.38; Crl 0.19-0.45). Network analysis showed that the Lactobacillus casei rhamnosus probiotic exhibited a 54.7% probability of being classified in first, while the probability of Lactobacillus fermentum CECT5716 (LFC) being last in the ranking was 15.3%. Lactobacillus casei rhamnosus showed no better effect compared to other probiotic strains by indirect analysis. CONCLUSION : This systematic review found a lack of evidence to support the effect of probiotic supplementation on the incidence rate of respiratory tract infections in children and adolescents.