Efeito da aplicação tópica de clorexidina, iodopovidona e eritromicina no reparo de úlceras traumáticas em ventre lingual de ratos : análise clínica, histológica e microbiológica

• Autor(a) principal: Teixeira, Dieni da Silveira
• Data de Publicação: 2017
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/7183
• topic: ÚLCERAS; CLOREXIDINA; CICATRIZAÇÃO (ODONTOLOGIA); ESTOMATOLOGIA CLÍNICA; ODONTOLOGIA; CIENCIAS DA SAUDE::ODONTOLOGIA

Oral mucosa is continuously subjected to traumatic injuries, being a common site for the occurrence of ulcerated lesions. These lesions are susceptible to infections that may delay healing. In the first article of this dissertation, a review of the literature was performed with the aim of understanding the mechanism of action and use of chlorhexidine, povidone-iodine and erythromycin in the healing process of oral wounds. These substances have particular characteristics, independent of their antimicrobial effect, which could favor the reestablishment of tissue architecture. However, few studies evaluated the effect of these drugs on the healing process of oral ulcers. Thus, the second article presents a study in animal model, which was carried out with the aim of to assessing the effect of 0.12% chlorhexidine, 10% povidone-iodine and 0.5% erythromycin in the repair of traumatic ulcers on ventral tongue. Forty-eight Wistar rats were divided into four groups: control, chlorhexidine, povidone-iodine and erythromycin. A 5-mm-diameter excisional wound was made in the center of ventral tongue. After 24 h, a microbiological sample was taken and daily application of the substances started. In six animals from each group, the applications were carried out for three days and in the others for seven days. Prior to euthanasia a new microbiological collection was performed. The photographic record of the residual lesions was obtained for clinical evaluation and, subsequently, the tongue was resected for histological analysis. In the clinical evaluation of the lesion area, the povidone-iodine and chlorhexidine groups presented significantly lower values compared to the control group after three days of treatment. Although the experimental groups presented higher values in the histomorphometric analysis of the epithelial tissue, there was no significant difference in relation to the control. The erythromycin group exhibited the lowest inflammation scores at seven days of treatment. Povidone-iodine showed the best results in the reduction of microorganisms in both experimental times and aerobic and microaerophilic conditions. Based on the results it is possible to conclude that the antimicrobials used in the present study favor the repair process of the oral wounds and may prevent the occurrence of infections. Among the substances tested, 10% povidone-iodine showed the best clinical, histological and microbiological results.