Formulação de um cold kit otimizada para marcação 99m Tc para diagnóstico de tumor neuroendócrino

• Autor(a) principal: Fernandes, Bruna
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/6150
• topic: RADIOFARMACÊUTICA; QUÍMICA NUCLEAR; NEOPLASIAS; NEUROENDOCRINOLOGIA; CIENCIAS DA SAUDE::FARMACIA

Several companies wordwide produce kits with 99mTc labelling for diagnosing neuroendocrine tumors. Aiming at producing this kind of product in Brazil, a formulation was proposed, based on the methodology developed by Guggenberg et ul, using HYNIC-TOC, SnCl2, EDDA, tricine, mannitol and ascorbic acid. For labelling the cold kit, metastable radionuclide technetium (99mTc), produced by a 99Mo generator was used. The product was stored at temperatures of 0 to 8°C and at 25°C before labelling. After the product was labelled, it was kept at room temperature for up to 4 hours. The time of exposure was sufficient to observe the shelf life of the product for each storage method. Considering a radiochemical purity (RCP) of 80%, the product remained stable during the eight-month storage at 0 to 8°C before labelling and up to 4 hours after labelling. Therefore, the use of this product is possible in centers of nuclear medicine for a longer period during the day.