An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da PUC_RS |
Texto Completo: | http://tede2.pucrs.br/tede2/handle/tede/6436 |
Resumo: | The growth of elder population is a global occurrence and is followed by an increased prevalence and incidence of dementia, especially Alzheimer disease (AD). As the disease progresses, there is a larger demand for special care, task mainly performed by their family, who mostly are also elderly spouses of the patients. These caregivers are being constantly afflicted by chronic stress, which in turn can become harmful to their health in a number of disorders, such as cognitive impairment. Current literature highlights: (I) Relation between chronic stress, aging and cognitive impairment; (II) Relation between chronic stress and changes on hormone levels, such as cortisol and dehydroepiandrosterone (DHEA), and neurotrophic factors, i.e. Brain-Derived Neurotrophic Factor (BDNF); (III) BDNF, DHEA and cortisol potentially modulate cognitive-related mechanisms. In the present study, the evidences were assessed conjointly to better characterize physiological and pathological mechanisms involved in the association between chronic stress, aging and cognitive deficits. Chronic stress effects on frontal and temporal lobes-dependent cognitive functions were investigated in familial caregivers of AD patients (n=17; 32 to 84 years old). The impact of chronic stress on cortisol, DHEA and BDNF levels was also assessed, and the relation of these physiological features on cognitive performance. Initial findings point that chronic stress is capable of impairing attention, executive functions and declarative memory, also increasing cortisol/DHEA ratio and reducing serum BDNF levels. Then, we assessed age effects on the relation of chronic stress, cognition; cortisol, DHEA, and BDNF, as older caregivers are, theoretically, more prone to chronic stress effects than its younger counterparts are. Our results supports this hypothesis, indicating that hormone and cognitive changes are of greater importance on older caregivers when compared with young caregivers. However, middle-aged caregivers also presented a significant cognitive impairment and more suceptibility to chronic stress effects on BDNF levels than older caregivers. The results presented in this thesis highlights that chronic stress-related cognitive alterations are resulting from, at least partly, cortisol, DHEA and BDNF level changes. However, the rate in which these cognitive features are affected, and its relation with the assessed hormones and neurotrophin are dependent on the caregivers? age. |
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Bromberg, Elke569.614.990-15http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785654J5006.970.930-00http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4489783P2Corr?a, M?rcio da Silveira2015-12-17T16:15:29Z2015-10-01http://tede2.pucrs.br/tede2/handle/tede/6436The growth of elder population is a global occurrence and is followed by an increased prevalence and incidence of dementia, especially Alzheimer disease (AD). As the disease progresses, there is a larger demand for special care, task mainly performed by their family, who mostly are also elderly spouses of the patients. These caregivers are being constantly afflicted by chronic stress, which in turn can become harmful to their health in a number of disorders, such as cognitive impairment. Current literature highlights: (I) Relation between chronic stress, aging and cognitive impairment; (II) Relation between chronic stress and changes on hormone levels, such as cortisol and dehydroepiandrosterone (DHEA), and neurotrophic factors, i.e. Brain-Derived Neurotrophic Factor (BDNF); (III) BDNF, DHEA and cortisol potentially modulate cognitive-related mechanisms. In the present study, the evidences were assessed conjointly to better characterize physiological and pathological mechanisms involved in the association between chronic stress, aging and cognitive deficits. Chronic stress effects on frontal and temporal lobes-dependent cognitive functions were investigated in familial caregivers of AD patients (n=17; 32 to 84 years old). The impact of chronic stress on cortisol, DHEA and BDNF levels was also assessed, and the relation of these physiological features on cognitive performance. Initial findings point that chronic stress is capable of impairing attention, executive functions and declarative memory, also increasing cortisol/DHEA ratio and reducing serum BDNF levels. Then, we assessed age effects on the relation of chronic stress, cognition; cortisol, DHEA, and BDNF, as older caregivers are, theoretically, more prone to chronic stress effects than its younger counterparts are. Our results supports this hypothesis, indicating that hormone and cognitive changes are of greater importance on older caregivers when compared with young caregivers. However, middle-aged caregivers also presented a significant cognitive impairment and more suceptibility to chronic stress effects on BDNF levels than older caregivers. The results presented in this thesis highlights that chronic stress-related cognitive alterations are resulting from, at least partly, cortisol, DHEA and BDNF level changes. However, the rate in which these cognitive features are affected, and its relation with the assessed hormones and neurotrophin are dependent on the caregivers? age.O crescimento da popula??o idosa ? um fen?meno mundial e vem acompanhado do aumento da incid?ncia e preval?ncia de dem?ncias, principalmente a Doen?a de Alzheimer (DA). ? medida que a DA progride cresce a demanda por cuidados especiais, tarefa desempenhada em grande parte por cuidadores familiares, os quais muitas vezes s?o os c?njuges dos pacientes, ou seja, tamb?m s?o idosos. Estes cuidadores sofrem constantemente de estresse cr?nico, o qual ? capaz de promover preju?zos ? sa?de num amplo espectro de disfun??es, entre as quais as altera??es cognitivas. A literatura evidencia: (I) rela??es entre estresse cr?nico, envelhecimento e altera??es cognitivas; (II) rela??es entre estresse cr?nico e altera??o dos n?veis de horm?nios, como o cortisol e a dehidroepiandrosterona (DHEA), e neurotrofinas, como o fator neurotr?fico derivado de c?rebro (BDNF); (III) o potencial do cortisol, DHEA e BDNF modularem mecanismos subjacentes a processos cognitivos. No presente trabalho estas evid?ncias foram avaliadas de forma conjunta, de maneira a auxiliar na caracteriza??o dos mecanismos fisiopatol?gicos envolvidos na associa??o entre estresse cr?nico, envelhecimento e d?ficits cognitivos. Os efeitos do estresse cr?nico sobre as fun??es cognitivas dependentes dos lobos frontais e temporais foram investigadas em cuidadores familiares de pacientes com DA (n= 17; 32 a 84 anos de idade). Foi analisado tamb?m o impacto do estresse cr?nico nos n?veis de Cortisol, DHEA e BDNF, bem como a rela??o destes par?metros fisiol?gicos com o desempenho em testes neuropsicol?gicos. Os achados iniciais indicaram que o estresse cr?nico ? capaz de prejudicar o desempenho em tarefas que avaliam aten??o, fun??es executivas e a mem?ria declarativa bem como elevar a raz?o cortisol/DHEA e diminuir os n?veis s?ricos de BDNF. Em um segundo momento, analisamos o efeito da idade sobre a rela??o entre estresse cr?nico, cogni??o e n?veis de cortisol, DHEA e BDNF, uma vez que cuidadores idosos teoricamente seriam mais suscet?veis aos efeitos do estresse cr?nico que cuidadores de meia idade. Os resultados obtidos comprovaram esta hip?tese, indicando altera??es hormonais e cognitivas mais importantes nos cuidadores idosos do que nos mais jovens. Todavia, os cuidadores de meia-idade tamb?m apresentaram um preju?zo cognitivo importante e mostraram-se mais sens?veis aos efeitos do estresse cr?nico sobre os n?veis de BDNF do que os cuidadores idosos. Os resultados apresentados nesta tese indicam que as altera??es cognitivas relacionadas ao estresse cr?nico s?o resultantes, pelo menos parcialmente, de altera??es nos n?veis de cortisol, DHEA e BDNF. Entretanto, o grau em que os aspectos cognitivos s?o afetados e sua rela??o com os horm?nios e a neurotrofina avaliados dependem da faixa et?ria do cuidador.Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-12-17T16:15:27Z No. of bitstreams: 1 476732 - Texto Completo.pdf: 4491937 bytes, checksum: 66c81650cd846fce81680ee4557d5e93 (MD5)Made available in DSpace on 2015-12-17T16:15:29Z (GMT). No. of bitstreams: 1 476732 - Texto Completo.pdf: 4491937 bytes, checksum: 66c81650cd846fce81680ee4557d5e93 (MD5) Previous issue date: 2015-10-01Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/163845/476732%20-%20Texto%20Completo.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Biologia Celular e MolecularPUCRSBrasilFaculdade de Bioci?nciasGERONTOLOGIA BIOM?DICABIOLOGIA CELULARIDOSOSENVELHECIMENTO - ASPECTOS BIOL?GICOSDOEN?A DE ALZHEIMERCUIDADORESESTRESSECOGNI??OCIENCIAS BIOLOGICAS::BIOLOGIA GERALAn?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNFinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis819824693009663736060060060060036528317262667714-16345593859312446972075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAIL476732 - Texto Completo.pdf.jpg476732 - Texto Completo.pdf.jpgimage/jpeg3737http://tede2.pucrs.br/tede2/bitstream/tede/6436/4/476732+-+Texto+Completo.pdf.jpg5df3aa854d76af539e53167dac721708MD54TEXT476732 - Texto Completo.pdf.txt476732 - Texto Completo.pdf.txttext/plain129245http://tede2.pucrs.br/tede2/bitstream/tede/6436/3/476732+-+Texto+Completo.pdf.txt61e3442b503faa184fa1416a973a51a2MD53ORIGINAL476732 - Texto Completo.pdf476732 - Texto Completo.pdfapplication/pdf4491937http://tede2.pucrs.br/tede2/bitstream/tede/6436/2/476732+-+Texto+Completo.pdf66c81650cd846fce81680ee4557d5e93MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8610http://tede2.pucrs.br/tede2/bitstream/tede/6436/1/license.txt5a9d6006225b368ef605ba16b4f6d1beMD51tede/64362015-12-17 20:00:27.722oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2015-12-17T22:00:27Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF |
title |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF |
spellingShingle |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF Corr?a, M?rcio da Silveira GERONTOLOGIA BIOM?DICA BIOLOGIA CELULAR IDOSOS ENVELHECIMENTO - ASPECTOS BIOL?GICOS DOEN?A DE ALZHEIMER CUIDADORES ESTRESSE COGNI??O CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
title_short |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF |
title_full |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF |
title_fullStr |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF |
title_full_unstemmed |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF |
title_sort |
An?lise dos efeitos do estresse cr?nico e do envelhecimento sobre a cogni??o de cuidadores familiares de pacientes com doen?a de Alzheimer e sua rela??o com os n?veis de cortisol, DHEA e BDNF |
author |
Corr?a, M?rcio da Silveira |
author_facet |
Corr?a, M?rcio da Silveira |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Bromberg, Elke |
dc.contributor.advisor1ID.fl_str_mv |
569.614.990-15 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785654J5 |
dc.contributor.authorID.fl_str_mv |
006.970.930-00 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4489783P2 |
dc.contributor.author.fl_str_mv |
Corr?a, M?rcio da Silveira |
contributor_str_mv |
Bromberg, Elke |
dc.subject.por.fl_str_mv |
GERONTOLOGIA BIOM?DICA BIOLOGIA CELULAR IDOSOS ENVELHECIMENTO - ASPECTOS BIOL?GICOS DOEN?A DE ALZHEIMER CUIDADORES ESTRESSE COGNI??O |
topic |
GERONTOLOGIA BIOM?DICA BIOLOGIA CELULAR IDOSOS ENVELHECIMENTO - ASPECTOS BIOL?GICOS DOEN?A DE ALZHEIMER CUIDADORES ESTRESSE COGNI??O CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
description |
The growth of elder population is a global occurrence and is followed by an increased prevalence and incidence of dementia, especially Alzheimer disease (AD). As the disease progresses, there is a larger demand for special care, task mainly performed by their family, who mostly are also elderly spouses of the patients. These caregivers are being constantly afflicted by chronic stress, which in turn can become harmful to their health in a number of disorders, such as cognitive impairment. Current literature highlights: (I) Relation between chronic stress, aging and cognitive impairment; (II) Relation between chronic stress and changes on hormone levels, such as cortisol and dehydroepiandrosterone (DHEA), and neurotrophic factors, i.e. Brain-Derived Neurotrophic Factor (BDNF); (III) BDNF, DHEA and cortisol potentially modulate cognitive-related mechanisms. In the present study, the evidences were assessed conjointly to better characterize physiological and pathological mechanisms involved in the association between chronic stress, aging and cognitive deficits. Chronic stress effects on frontal and temporal lobes-dependent cognitive functions were investigated in familial caregivers of AD patients (n=17; 32 to 84 years old). The impact of chronic stress on cortisol, DHEA and BDNF levels was also assessed, and the relation of these physiological features on cognitive performance. Initial findings point that chronic stress is capable of impairing attention, executive functions and declarative memory, also increasing cortisol/DHEA ratio and reducing serum BDNF levels. Then, we assessed age effects on the relation of chronic stress, cognition; cortisol, DHEA, and BDNF, as older caregivers are, theoretically, more prone to chronic stress effects than its younger counterparts are. Our results supports this hypothesis, indicating that hormone and cognitive changes are of greater importance on older caregivers when compared with young caregivers. However, middle-aged caregivers also presented a significant cognitive impairment and more suceptibility to chronic stress effects on BDNF levels than older caregivers. The results presented in this thesis highlights that chronic stress-related cognitive alterations are resulting from, at least partly, cortisol, DHEA and BDNF level changes. However, the rate in which these cognitive features are affected, and its relation with the assessed hormones and neurotrophin are dependent on the caregivers? age. |
publishDate |
2015 |
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2015-12-17T16:15:29Z |
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2015-10-01 |
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por |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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Programa de P?s-Gradua??o em Biologia Celular e Molecular |
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PUCRS |
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Brasil |
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