Efeito tópico da doxiciclina e da dexametasona em úlceras confeccionadas na língua de ratos : análise clínica e histológica

• Autor(a) principal: Piacentini, Marcello
• Data de Publicação: 2018
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/8436
• topic: Úlceras Orais; Doxiciclina; Dexametasona; Cicatrização; CIENCIAS DA SAUDE::ODONTOLOGIA

Ulcerative lesions of the oral mucosa are frequent and can be caused by factors such as trauma, chemical substances, autoimmune disorders and infectious processes, among others. Control of the inflammatory process is desirable and may optimize the repair of ulcerative lesions on the oral mucosa. Topical corticosteroids, such as dexamethasone, have been commonly drugs used for this purpose, but they may have some adverse effects. Doxycycline is an antibiotic of the tetracycline group, which has important anti-inflammatory properties. Studies investigating its effects on oral mucosal lesions are still scarce. In the first article, a literature review was carried out investigating the effect of doxycycline on ulcerative oral lesions. Three randomized and controlled clinical trials were selected in which doxycycline was used in the treatment of recurrent aphthous ulcerations and one in patients with herpes labialis. Doxycycline promoted faster clinical remission of lesions and lower pain scores compared to controls. In the second article, an experimental study was performed in Wistar rats (n=66), in which ulcers were mechanically induced on the ventral tongue, to compare the topical effect of 0.5 mg/5 ml dexamethasone and 20 mg/ml doxycycline. The drugs were applied as a gel twice a day for three or seven days. After euthanasia, the area of residual ulcer was analyzed and the tongue was sectioned for histological analysis. No significant differences were observed among dexamethasone, doxycycline and control groups regarding to area of residual ulcer at three (P=0.798) and seven (P=0.074) days of treatment. Histological analysis also showed no differences among the groups regarding newly formed epithelium area (P=0.211, P=0.57), or inflammatory infiltrate (P=0.147, P=0.881) at three and seven days. Taking into account the experimental model, dexamethasone and doxycycline did not accelerate the repair of mechanically induced ulcers in the oral mucosa nor did they reduce the intensity of the inflammatory infiltrate.