Impacto da cirurgia bariátrica (bypass y-de-roux) nos componentes da síndrome metabólica e no uso de medicamentos associados

• Autor(a) principal: Junges, Vilma Maria Silva
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/6204
• topic: MEDICINA; GERONTOLOGIA; ENVELHECIMENTO; SÍNDROME METABÓLICA; OBESIDADE; CIRURGIA BARIÁTRICA; MEDICAMENTOS - USO TERAPÊUTICO; CIENCIAS DA SAUDE::MEDICINA

Context : prevalence of obesity and metabolic syndrome (MetS) are increasing worldwide, behavioral modification therapy (diet and regular physical exercise) and pharmacotherapy present little success and low adherence to the treatment of these pathologies. Bariatric surgery for bypass technique, however, has shown promising and effective results in both, reducing weight and associated comorbidities of obese patients II and III. Objective: to evaluate the impact of gastric bypass in MetS components and in the use of associated drugs.Method : historical cohort, follow-up for six months, analyzing a sample composed by 273 obese people [236 (86.4%) female and 37 (13.6%) males] grade II and grade III, aged ≥ 20 years, with or without MetS who underwent bariatric surgery by Roux-en-Y bypass technique between January 2007 and March 2014. All patients were followed for a period of six months after surgery and evaluated at 60, 120 and 180 days after surgery. The socio-demographic, anthropometric, biochemical, clinical and medication use data were collected from medical records of patients.Results : the results show significant statistical differences in post-operative period, either 60, 120 or 180 days, concerning the following variables: weight (p <0.001), BMI (p <0.001), CA (p <0.001), SAP (p <0.001), DBP (p <0.001), glucose (P = 0.005 post 60 and p <0.001 post 120 and 180 days), triglycerides (p <0.001). In relation to HDL levels did not change was observed (p> 0.05). Concerning the use of drugs, were also observed significant statistical reductions in the use of antihypertensive drugs (p <0.001), hypoglycaemics (p <0.001) and lipid-lowering (p <0.001).Conclusions : that patients who underwent Roux-en-Y gastric bypass had a weight loss and an improvement in MetS components (except HDL) and in the use of drugs associated with obesity and MetS.