Correlação entre fibromialgia e desordens temporomandibulares : avaliação dos níveis salivares de IL‐1β

• Autor(a) principal: Cé, Patricia dos Santos
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/6186
• topic: ODONTOLOGIA; FIBROMIALGIA; ARTICULAÇÃO TEMPOROMANDIBULAR - DISFUNÇÕES; CITOCINAS; CIENCIAS DA SAUDE::ODONTOLOGIA

This study examined the association between fibromyalgia and temporomandibular disorders (TMD). The relationship between these disorders has been investigated by analysis of the pro-inflammatory cytokine, interleukin-1β (IL-1β) in the saliva of patients with temporomandibular disorders (TMD); fibromyalgia; Fibromyalgia + temporomandibular disorder; individuals without any of the two conditions (control group), correlating the levels of IL-1β with the clinical findings. All the participants of the study were female, aged from 20 to 84 years. The Group A consisted of 14 healthy patients; the Group B consisted of 17 patients with TMD; the Group C consisted of 11 patients with fibromyalgia; and the Group D consisted of 7 patients with TMD and fibromyalgia associated. The research was conducted in the clinical disciplines of Occlusion and Surgery, at the Dental School, and the Rheumatology Service of Hospital São Lucas, of the Pontifical Catholic University of Rio Grande do Sul (PUCRS). The clinical data collection was performed through anamnesis and clinical examination of all groups was performed using the Research Diagnostic Criteria (RDC) for evaluation of TMD, axis I and II for groups B and D; RDC axis I for groups A and D. Saliva samples were collected in a single session, after signing the free and informed consent. After collection, the samples were stored in a freezer at -20 ° C. The concentrations of the inflammatory cytokine IL-1β were evaluated by enzyme assay (ELISA). Data was submitted to descriptive and statistical analyzes. In the four groups the white race was prevalent. Regarding the medical history of the patients in the Group A, bruxism and allergic rhinitis were the most frequent diseases; in the Group B beyond DTM, osteoarthritis and hypertension (HA) were the most prevalent; in the Group C, in addition to fibromyalgia, HA prevailed; in the group D, besides FM and TMD, the pathologies presented were different, without homogeneity. The drugs most used by the participants of the study were: contraceptives for Group A; antihypertensive drugs, antidepressants, and muscle relaxants for Group B; analgesics, anti-inflammatory drugs, antihypertensive agents and antidepressants for the Group C; antidepressants and analgesics for the Group D. The results revealed that there were no differences among the mouth opening degree throughout the four groups, and in all prevailed mouth opening ≥ 35 mm, which is considered satisfactory. The levels of IL-1β were significantly higher in the Groups B, C and D, when compared to the Group A. When analyzed individually, the use of contraceptives may also have influenced the levels of IL-1β. The other variables did not show any influence on IL-1β levels. The completion of this study shows: (i) the existence of a relationship between the investigated diseases and the increase in salivary concentrations of IL-1β; (ii) there was no correlation between the increase in IL-1β and mouth opening; (iii) other studies need to be carried out by increasing the experimental sample and by evaluating IL-1β levels in patients without fibromyalgia or TMD, aged between 40 and 60 years.