Avaliação da atividade antioxidante, antiinflamatória e antinociceptiva do óleo essencial de lavanda (Lavandula angustifolia Mill)

• Autor(a) principal: Silva, Gabriela Lucas da
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
• Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/6369
• topic: BIOLOGIA CELULAR; BIOLOGIA MOLECULAR; ÓLEOS ESSENCIAIS; INFLAMAÇÃO; DOR; ANTIOXIDANTES; CIENCIAS BIOLOGICAS::BIOLOGIA GERAL

In this study, we evaluated the antinociceptive, antiinflammatory and antioxidant effects of lavender essential oil. The antioxidant activity was tested in vitro and used as screening for subsequent experiments. In animals, the effect of lavender essential oil was compared to those displayed by known antiinflammatory and analgesic drugs (dexamethasone, tramadol and indomethacine). Attempts have been made in order to suggest a probable mechanism of action. Considering the pharmacological potential of the lavender essential oil, we have also investigated its possible toxic effects. We demonstrated that the dose of 0,6 g/kg is well tolerated orally. This dose was considered safe and was used in subsequent experiments. The antiinflamatory activity was tested using two models of acute inflammation: the pleurisy induced by carrageenan and the ear edema induced by croton oil. The inflammatory response evoked by carrageenan and by croton oil were reduced by the pre-treatment of animals with lavender oil. On pleurisy, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to the obtained for dexamethasone.The antinociceptive activity was tested using the model of pain induced by formalin injection into the hind paw of rats. In this model, lavender oil consistently inhibited nociception and presented a similar effect to tramadol. This finding suggests that the mechanism involved in the antiinflammatory effect of lavender may be related to interference in the system of intracellular second messenger phospholipase C/inositol phosphate. In conclusion, the results of this study reveal remarkable analgesic and antiinflammatory activities for the lavender essential oil. Furthermore, the effectiveness of the oil associated with the low toxicity support the interest for the application of lavender essential oil in aromatherapy, and demonstrated its important therapeutic potential.