GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors

Detalhes bibliográficos
Autor(a) principal: Gomes, Catarina
Data de Publicação: 2009
Outros Autores: Simões, Patrícia F., Canas, Paula M., Quiroz, César, Sebastião, Ana M, Ferré, Sergi, Cunha, Rodrigo A., Ribeiro, Joaquim A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55416
Resumo: © 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistry
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spelling GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptorsA2A receptorAdenosineCortico-striatal pathwayGlial cell line-derived neurotrophic factorGlutamateRearranged during transfection/GDNF family receptor a1© 2009 The Authors. Journal Compilation © 2009 International Society for NeurochemistryGlial cell line-derived neurotrophic factor (GDNF) affords neuroprotection in Parkinson's disease in accordance with its ability to bolster nigrostriatal innervation. We previously found that GDNF facilitates dopamine release in a manner dependent on adenosine A(2A) receptor activation. As motor dysfunction also involves modifications of striatal glutamatergic innervation, we now tested if GDNF and its receptor system, Ret (rearranged during transfection) and GDNF family receptor alpha1 controlled the cortico-striatal glutamatergic pathway in an A(2A) receptor-dependent manner. GDNF (10 ng/mL) enhanced (by approximately 13%) glutamate release from rat striatal nerve endings, an effect potentiated (up to approximately 30%) by the A(2A) receptor agonist CGS 21680 (10 nM) and prevented by the A(2A) receptor antagonist, SCH 58261 (50 nM). Triple immunocytochemical studies revealed that Ret and GDNF family receptor alpha1 were located in 50% of rat striatal glutamatergic terminals (immunopositive for vesicular glutamate transporters-1/2), where they were found to be co-located with A(2A) receptors. Activation of the glutamatergic system upon in vivo electrical stimulation of the rat cortico-striatal input induced striatal Ret phosphorylation that was prevented by pre-treatment with the A(2A) receptor antagonist, MSX-3 (3 mg/kg). The results provide the first functional and morphological evidence that GDNF controls cortico-striatal glutamatergic pathways in a manner largely dependent on the co-activation of adenosine A(2A) receptors.This study was supported by Fundação para a Ciência e para a Tecnologia, Portugal (work at Lisboa and Coimbra) and by the Intramural Research funds of the National Institute on Drug Abuse, NIH, USA and Faculdade de Medicina, Universidade de Lisboa, Portugal.WileyRepositório da Universidade de LisboaGomes, CatarinaSimões, Patrícia F.Canas, Paula M.Quiroz, CésarSebastião, Ana MFerré, SergiCunha, Rodrigo A.Ribeiro, Joaquim A.2022-12-15T12:13:50Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55416engJ Neurochem. 2009 Mar;108(5):1208-12190022-304210.1111/j.1471-4159.2009.05876.x1471-4159info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:21Zoai:repositorio.ul.pt:10451/55416Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:03.524209Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
title GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
spellingShingle GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
Gomes, Catarina
A2A receptor
Adenosine
Cortico-striatal pathway
Glial cell line-derived neurotrophic factor
Glutamate
Rearranged during transfection/GDNF family receptor a1
title_short GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
title_full GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
title_fullStr GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
title_full_unstemmed GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
title_sort GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors
author Gomes, Catarina
author_facet Gomes, Catarina
Simões, Patrícia F.
Canas, Paula M.
Quiroz, César
Sebastião, Ana M
Ferré, Sergi
Cunha, Rodrigo A.
Ribeiro, Joaquim A.
author_role author
author2 Simões, Patrícia F.
Canas, Paula M.
Quiroz, César
Sebastião, Ana M
Ferré, Sergi
Cunha, Rodrigo A.
Ribeiro, Joaquim A.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gomes, Catarina
Simões, Patrícia F.
Canas, Paula M.
Quiroz, César
Sebastião, Ana M
Ferré, Sergi
Cunha, Rodrigo A.
Ribeiro, Joaquim A.
dc.subject.por.fl_str_mv A2A receptor
Adenosine
Cortico-striatal pathway
Glial cell line-derived neurotrophic factor
Glutamate
Rearranged during transfection/GDNF family receptor a1
topic A2A receptor
Adenosine
Cortico-striatal pathway
Glial cell line-derived neurotrophic factor
Glutamate
Rearranged during transfection/GDNF family receptor a1
description © 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistry
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2022-12-15T12:13:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55416
url http://hdl.handle.net/10451/55416
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neurochem. 2009 Mar;108(5):1208-1219
0022-3042
10.1111/j.1471-4159.2009.05876.x
1471-4159
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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