Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology

Detalhes bibliográficos
Autor(a) principal: Silva, Simone Santos
Data de Publicação: 2011
Outros Autores: Mano, J. F., Reis, R. L., Carvalho, Ana Paula, Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/12848
Resumo: The application of green chemistry principles in the processing of materials for advanced technologies is a steadily increasing field of research. In this work porous chitin-based materials were developed by combining the processing of chitin using ionic liquids (ILs)as a green solvent together with the use of super- critical fluid technology(SCF) as clean technology.Chitin was dissolved in 1-butyl-3-imidazolium acetate,followed by regeneration of the polymer in ethanol in specific moulds.The IL was removed using Soxhlet extraction and successive steps of extraction with SCF using carbon dioxide/ethanol ratios of 50/ 50 and70/30.The developed porous chitin-based structures (ChIL)can be classified as mesoporous materials,with very low density and high porosity.The cytotoxicity of ChIL extracts was investigated using L929 fibroblast like cells,and the results demonstrated that the produced materials have extremely lowcytotoxicityl evels.Therefore,the findings suggest that the porous chitin structures may be potential candidates for a number of biomedical applications,including tissue engineering.
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spelling Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technologyChitinIonic liquidsSupercritical fluid technologyGreen chemistryBiomedical applicationsBiomaterialsSupercritical dryingScience & TechnologyThe application of green chemistry principles in the processing of materials for advanced technologies is a steadily increasing field of research. In this work porous chitin-based materials were developed by combining the processing of chitin using ionic liquids (ILs)as a green solvent together with the use of super- critical fluid technology(SCF) as clean technology.Chitin was dissolved in 1-butyl-3-imidazolium acetate,followed by regeneration of the polymer in ethanol in specific moulds.The IL was removed using Soxhlet extraction and successive steps of extraction with SCF using carbon dioxide/ethanol ratios of 50/ 50 and70/30.The developed porous chitin-based structures (ChIL)can be classified as mesoporous materials,with very low density and high porosity.The cytotoxicity of ChIL extracts was investigated using L929 fibroblast like cells,and the results demonstrated that the produced materials have extremely lowcytotoxicityl evels.Therefore,the findings suggest that the porous chitin structures may be potential candidates for a number of biomedical applications,including tissue engineering.Fundação para a Ciência e Tecnologia (FCT)S.S.S. and A.R.C.D. thank the Portuguese Foundation for Science and Technology (FCT) for post-doctoral fellowships (SFRH/BPD/ 45307/2008 and SFRH/BDP/34994/2007, respectively). This work was partially supported by the FCT (Project PTDC/QUI/68804/ 2006) and was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283).ElsevierUniversidade do MinhoSilva, Simone SantosMano, J. F.Reis, R. L.Carvalho, Ana PaulaDuarte, Ana Rita C.20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/12848engSilva S. S., Duarte A. R. C., Carvalho A. P. B., Mano J. F., Reis R. L. Green processing of chitin porous structures for biomedical aapplications combining ionic liquids and supercritical fluid technology, Acta Biomaterialia, Vol. 7, pp. 1166-1172, doi:10.1016/j.actbio.2010.09.041, 20111742-70611878-756810.1016/j.actbio.2010.09.04120933617http://www.sciencedirect.com/science/article/pii/S1742706110004514info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:43:30Zoai:repositorium.sdum.uminho.pt:1822/12848Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:41:00.115499Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
title Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
spellingShingle Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
Silva, Simone Santos
Chitin
Ionic liquids
Supercritical fluid technology
Green chemistry
Biomedical applications
Biomaterials
Supercritical drying
Science & Technology
title_short Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
title_full Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
title_fullStr Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
title_full_unstemmed Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
title_sort Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology
author Silva, Simone Santos
author_facet Silva, Simone Santos
Mano, J. F.
Reis, R. L.
Carvalho, Ana Paula
Duarte, Ana Rita C.
author_role author
author2 Mano, J. F.
Reis, R. L.
Carvalho, Ana Paula
Duarte, Ana Rita C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Simone Santos
Mano, J. F.
Reis, R. L.
Carvalho, Ana Paula
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Chitin
Ionic liquids
Supercritical fluid technology
Green chemistry
Biomedical applications
Biomaterials
Supercritical drying
Science & Technology
topic Chitin
Ionic liquids
Supercritical fluid technology
Green chemistry
Biomedical applications
Biomaterials
Supercritical drying
Science & Technology
description The application of green chemistry principles in the processing of materials for advanced technologies is a steadily increasing field of research. In this work porous chitin-based materials were developed by combining the processing of chitin using ionic liquids (ILs)as a green solvent together with the use of super- critical fluid technology(SCF) as clean technology.Chitin was dissolved in 1-butyl-3-imidazolium acetate,followed by regeneration of the polymer in ethanol in specific moulds.The IL was removed using Soxhlet extraction and successive steps of extraction with SCF using carbon dioxide/ethanol ratios of 50/ 50 and70/30.The developed porous chitin-based structures (ChIL)can be classified as mesoporous materials,with very low density and high porosity.The cytotoxicity of ChIL extracts was investigated using L929 fibroblast like cells,and the results demonstrated that the produced materials have extremely lowcytotoxicityl evels.Therefore,the findings suggest that the porous chitin structures may be potential candidates for a number of biomedical applications,including tissue engineering.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/12848
url http://hdl.handle.net/1822/12848
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva S. S., Duarte A. R. C., Carvalho A. P. B., Mano J. F., Reis R. L. Green processing of chitin porous structures for biomedical aapplications combining ionic liquids and supercritical fluid technology, Acta Biomaterialia, Vol. 7, pp. 1166-1172, doi:10.1016/j.actbio.2010.09.041, 2011
1742-7061
1878-7568
10.1016/j.actbio.2010.09.041
20933617
http://www.sciencedirect.com/science/article/pii/S1742706110004514
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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