Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity

Detalhes bibliográficos
Autor(a) principal: Cotter, José de Almeida Berkeley
Data de Publicação: 2015
Outros Autores: Castro, Francisca Dias de, Magalhães, Joana, Moreira, Maria João, Rosa, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/32374
Resumo: "Published online: 2014"
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spelling Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activityScience & Technology"Published online: 2014"Background and study aims: The Lewis score was developed to measure mucosal inflammatory activity as detected by small-bowel capsule endoscopy (SBCE). The aim of the current study was to validate the Lewis score by assessing interobserver correlation and level of agreement in a clinical setting. Patients and methods: This was a retrospective, single-center, double-blind study including patients with isolated small-bowel Crohn's disease who underwent SBCE. The Lewis score was calculated using a software application, based on the characteristics of villous edema, ulcers, and stenoses. The Lewis score was independently calculated by one of three investigators and by a central reader (gold standard). Interobserver agreement was assessed using intraclass correlation (ICC) coefficient and Bland - Altman plots. Results: A total of 70 patients were consecutively included (mean age 33.9 ± 11.7 years). The mean Lewis score was 1265 and 1320 for investigators and the central reader, respectively. There was a high correlation, both for scores obtained for each tertile (first tertile r = 0.659 - 0.950, second tertile r = 0.756 - 0.906, third tertile r = 0.750 - 0.939), and for the global score (r = 0.745 - 0.928) (P < 0.0001). Interobserver agreement was almost perfect between the investigators and the central reader (first tertile ICC = 0.788 - 0.971, second tertile ICC = 0.824 - 0.943, third tertile ICC = 0.857 - 0.968, global score ICC = 0.852 - 0.960; P < 0.0001). The inflammatory activity was classified as normal (score < 135) in 2.9 % vs. 2.9 %, mild (score ≥ 135 - < 790) in 51.4 % vs. 55.7 %, and moderate to severe (score ≥ 790) in 45.8 % vs. 41.4 % of patients, respectively (P < 0.001). Conclusion: A strong interobserver agreement was demonstrated for the determination of the Lewis score in a practical clinical setting, validating this score for the reporting of small-bowel inflammatory activity. The Lewis score might be used for diagnosing, staging, follow-up, and therapeutic assessment of patients with isolated small-bowel Crohn's disease.Georg Thieme VerlagUniversidade do MinhoCotter, José de Almeida BerkeleyCastro, Francisca Dias deMagalhães, JoanaMoreira, Maria JoãoRosa, Bruno20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32374engCotter, J., de Castro, F. D., Magalhaes, J., Moreira, M. J., & Rosa, B. (2015). Validation of the Lewis score for the evaluation of small-bowel Crohn's disease activity. Endoscopy, 47(4), 330-335. doi: 10.1055/s-0034-13908940013-726X10.1055/s-0034-139089425412092http://www.thieme.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:09Zoai:repositorium.sdum.uminho.pt:1822/32374Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:52:28.185570Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
title Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
spellingShingle Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
Cotter, José de Almeida Berkeley
Science & Technology
title_short Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
title_full Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
title_fullStr Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
title_full_unstemmed Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
title_sort Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity
author Cotter, José de Almeida Berkeley
author_facet Cotter, José de Almeida Berkeley
Castro, Francisca Dias de
Magalhães, Joana
Moreira, Maria João
Rosa, Bruno
author_role author
author2 Castro, Francisca Dias de
Magalhães, Joana
Moreira, Maria João
Rosa, Bruno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Cotter, José de Almeida Berkeley
Castro, Francisca Dias de
Magalhães, Joana
Moreira, Maria João
Rosa, Bruno
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description "Published online: 2014"
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/32374
url http://hdl.handle.net/1822/32374
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cotter, J., de Castro, F. D., Magalhaes, J., Moreira, M. J., & Rosa, B. (2015). Validation of the Lewis score for the evaluation of small-bowel Crohn's disease activity. Endoscopy, 47(4), 330-335. doi: 10.1055/s-0034-1390894
0013-726X
10.1055/s-0034-1390894
25412092
http://www.thieme.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag
publisher.none.fl_str_mv Georg Thieme Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133116730703872

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