Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.

Detalhes bibliográficos
Autor(a) principal: Mansoor, T.A.
Data de Publicação: 2009
Outros Autores: Ramalhete, Cátia, Mulhovo, Silva, Molnar, Joseph, Ferreira, Maria José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10884/1324
Resumo: Three novel beta-carboline indole alkaloids (1-3) have been isolated from a MeOH extract of the leaves of Tabernaemontana elegans. The structures were established by means of spectroscopic techniques including 2D NMR experiments. Compounds 1 and 2 contain a two-carbon unit, attached to a structurally related beta-carboline skeleton, as part of an additional six-membered ring in 1 and a seven-membered ring in 2. To the best of our knowledge, this is the first report of beta-carboline indole alkaloids from the genus Tabernaemontana. Compounds 1-3 were evaluated for their ability to modulate multidrug resistance in mouse lymphoma cell lines. Compounds 1 and 3 exhibited a weak activity.
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spelling Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.Three novel beta-carboline indole alkaloids (1-3) have been isolated from a MeOH extract of the leaves of Tabernaemontana elegans. The structures were established by means of spectroscopic techniques including 2D NMR experiments. Compounds 1 and 2 contain a two-carbon unit, attached to a structurally related beta-carboline skeleton, as part of an additional six-membered ring in 1 and a seven-membered ring in 2. To the best of our knowledge, this is the first report of beta-carboline indole alkaloids from the genus Tabernaemontana. Compounds 1-3 were evaluated for their ability to modulate multidrug resistance in mouse lymphoma cell lines. Compounds 1 and 3 exhibited a weak activity.Journal of Natural Products2018-08-28T11:38:09Z2009-06-01T00:00:00Z2009-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10884/1324engMansoor, T.A.Ramalhete, CátiaMulhovo, SilvaMolnar, JosephFerreira, Maria Joséinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-04T11:08:02Zoai:repositorio-cientifico.uatlantica.pt:10884/1324Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:29:53.934138Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
title Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
spellingShingle Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
Mansoor, T.A.
title_short Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
title_full Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
title_fullStr Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
title_full_unstemmed Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
title_sort Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
author Mansoor, T.A.
author_facet Mansoor, T.A.
Ramalhete, Cátia
Mulhovo, Silva
Molnar, Joseph
Ferreira, Maria José
author_role author
author2 Ramalhete, Cátia
Mulhovo, Silva
Molnar, Joseph
Ferreira, Maria José
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mansoor, T.A.
Ramalhete, Cátia
Mulhovo, Silva
Molnar, Joseph
Ferreira, Maria José
description Three novel beta-carboline indole alkaloids (1-3) have been isolated from a MeOH extract of the leaves of Tabernaemontana elegans. The structures were established by means of spectroscopic techniques including 2D NMR experiments. Compounds 1 and 2 contain a two-carbon unit, attached to a structurally related beta-carboline skeleton, as part of an additional six-membered ring in 1 and a seven-membered ring in 2. To the best of our knowledge, this is the first report of beta-carboline indole alkaloids from the genus Tabernaemontana. Compounds 1-3 were evaluated for their ability to modulate multidrug resistance in mouse lymphoma cell lines. Compounds 1 and 3 exhibited a weak activity.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01T00:00:00Z
2009-06
2018-08-28T11:38:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10884/1324
url http://hdl.handle.net/10884/1324
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Natural Products
publisher.none.fl_str_mv Journal of Natural Products
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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