Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study

Detalhes bibliográficos
Autor(a) principal: Timóteo, AT
Data de Publicação: 2019
Outros Autores: Mota Carmo, M, Soares, C, Cruz Ferreira, R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3421
Resumo: BACKGROUND: Carotid intima-media thickness (CIMT) is an established surrogate marker for cardiovascular events in patients with intermediate risk. In patients with high cardiovascular risk or established cardiovascular disease, the impact of CMIT measurement on risk stratification for future events is less clear. Our objective was to evaluate the impact of CIMT on the occurrence of cardiovascular events in a cohort of individuals with high cardiovascular risk, in long-term follow-up. METHODS: We analyzed 296 individuals, mean follow-up of 6.9 ± 2.2 years. Individuals were divided into tertiles according to CIMT. Tertiles were compared in terms of baseline characteristics and outcomes during follow-up-all-cause mortality and composite outcome (mortality, acute coronary syndromes, coronary revascularization, stroke/transient ischemic attack, heart failure, or cardiovascular admission). RESULTS: Our population had a mean age of 65 ± 9 years at the beginning of the study, 55% males. Patients with higher CIMT showed a trend for higher cardiovascular mortality (P = 0.084) and for the composite outcome (P = 0.049). A CIMT ≥ 0.85 mm was also associated with higher rate of events; however, CIMT was not an independent predictor of outcome after adjustment for age and gender. CIMT assessment was useful in patients with hypertension, hyperlipidemia, and metabolic syndrome and in nondiabetic patients. For the composite outcome, it was also useful in females, smokers, and in patients without coronary artery disease. CONCLUSIONS: Patients with higher CIMT have worst outcome, but this was mainly driven by age and gender. CIMT is useful as a prognostic marker in specific subsets of patients.
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spelling Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort StudyAgedCardiovascular DiseasesCarotid Intima-Media ThicknessCohort StudiesCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisProspective StudiesRiskHSM CARBACKGROUND: Carotid intima-media thickness (CIMT) is an established surrogate marker for cardiovascular events in patients with intermediate risk. In patients with high cardiovascular risk or established cardiovascular disease, the impact of CMIT measurement on risk stratification for future events is less clear. Our objective was to evaluate the impact of CIMT on the occurrence of cardiovascular events in a cohort of individuals with high cardiovascular risk, in long-term follow-up. METHODS: We analyzed 296 individuals, mean follow-up of 6.9 ± 2.2 years. Individuals were divided into tertiles according to CIMT. Tertiles were compared in terms of baseline characteristics and outcomes during follow-up-all-cause mortality and composite outcome (mortality, acute coronary syndromes, coronary revascularization, stroke/transient ischemic attack, heart failure, or cardiovascular admission). RESULTS: Our population had a mean age of 65 ± 9 years at the beginning of the study, 55% males. Patients with higher CIMT showed a trend for higher cardiovascular mortality (P = 0.084) and for the composite outcome (P = 0.049). A CIMT ≥ 0.85 mm was also associated with higher rate of events; however, CIMT was not an independent predictor of outcome after adjustment for age and gender. CIMT assessment was useful in patients with hypertension, hyperlipidemia, and metabolic syndrome and in nondiabetic patients. For the composite outcome, it was also useful in females, smokers, and in patients without coronary artery disease. CONCLUSIONS: Patients with higher CIMT have worst outcome, but this was mainly driven by age and gender. CIMT is useful as a prognostic marker in specific subsets of patients.WileyRepositório do Centro Hospitalar Universitário de Lisboa Central, EPETimóteo, ATMota Carmo, MSoares, CCruz Ferreira, R2020-02-06T15:02:34Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3421engEchocardiography. 2019 Jan;36(1):125-132.10.1111/echo.14207info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:42:55Zoai:repositorio.chlc.min-saude.pt:10400.17/3421Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:43.930628Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
title Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
spellingShingle Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
Timóteo, AT
Aged
Cardiovascular Diseases
Carotid Intima-Media Thickness
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Risk
HSM CAR
title_short Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
title_full Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
title_fullStr Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
title_full_unstemmed Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
title_sort Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Cardiovascular Risk? A Long-Term Cohort Study
author Timóteo, AT
author_facet Timóteo, AT
Mota Carmo, M
Soares, C
Cruz Ferreira, R
author_role author
author2 Mota Carmo, M
Soares, C
Cruz Ferreira, R
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Timóteo, AT
Mota Carmo, M
Soares, C
Cruz Ferreira, R
dc.subject.por.fl_str_mv Aged
Cardiovascular Diseases
Carotid Intima-Media Thickness
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Risk
HSM CAR
topic Aged
Cardiovascular Diseases
Carotid Intima-Media Thickness
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Risk
HSM CAR
description BACKGROUND: Carotid intima-media thickness (CIMT) is an established surrogate marker for cardiovascular events in patients with intermediate risk. In patients with high cardiovascular risk or established cardiovascular disease, the impact of CMIT measurement on risk stratification for future events is less clear. Our objective was to evaluate the impact of CIMT on the occurrence of cardiovascular events in a cohort of individuals with high cardiovascular risk, in long-term follow-up. METHODS: We analyzed 296 individuals, mean follow-up of 6.9 ± 2.2 years. Individuals were divided into tertiles according to CIMT. Tertiles were compared in terms of baseline characteristics and outcomes during follow-up-all-cause mortality and composite outcome (mortality, acute coronary syndromes, coronary revascularization, stroke/transient ischemic attack, heart failure, or cardiovascular admission). RESULTS: Our population had a mean age of 65 ± 9 years at the beginning of the study, 55% males. Patients with higher CIMT showed a trend for higher cardiovascular mortality (P = 0.084) and for the composite outcome (P = 0.049). A CIMT ≥ 0.85 mm was also associated with higher rate of events; however, CIMT was not an independent predictor of outcome after adjustment for age and gender. CIMT assessment was useful in patients with hypertension, hyperlipidemia, and metabolic syndrome and in nondiabetic patients. For the composite outcome, it was also useful in females, smokers, and in patients without coronary artery disease. CONCLUSIONS: Patients with higher CIMT have worst outcome, but this was mainly driven by age and gender. CIMT is useful as a prognostic marker in specific subsets of patients.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-02-06T15:02:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3421
url http://hdl.handle.net/10400.17/3421
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Echocardiography. 2019 Jan;36(1):125-132.
10.1111/echo.14207
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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