Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/3018 |
Resumo: | Several variables, including age, are known to influence anxiety. Previous exposure to the elevated-plus maze (EPM) is known to modify emotional behaviour as retesting in the EPM at a standard age of 3 months increases open-arm avoidance and attenuates the effects of anxiolytic drugs. This study analysed whether similar results are obtained when older animals are subjected to these experimental paradigms. Overall, increasing age was associated with more signs of anxiety. Additionally, we observed a paradoxical behaviour pattern in aged-subjects that were re-exposed to the EPM, with mid-aged and old rats failing to display open arm avoidance (OAA) in the second trial; this qualitative shift in emotional behaviour was not associated with decreased locomotion. An examination of how age influences responsiveness to anxiolytic drugs, with or without previous maze experience, was also conducted. Midazolam (0.5 and 1 mg/kg) proved anxiolytic in maize-naive young animals; in marked contrast, in older animals midazolam at 1 mg/kg resulted in sedation but not anxiolyis. One trial tolerance to midazolam was evident in animals of both ages that were subjected to a second EPM trial; the latter phenomenon was apparently accentuated in older animals as they do not show open arm avoidance upon re-exposure to the EPM. These data suggest that the age-associated ‘resistance’ to anxiolytic drugs might be related to a qualitative shift in emotional behaviour. |
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Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus mazeAgingAnxietyOpen arm avoidanceOne trial toleranceRisk assessmentElevated-plus mazeRatScience & TechnologySeveral variables, including age, are known to influence anxiety. Previous exposure to the elevated-plus maze (EPM) is known to modify emotional behaviour as retesting in the EPM at a standard age of 3 months increases open-arm avoidance and attenuates the effects of anxiolytic drugs. This study analysed whether similar results are obtained when older animals are subjected to these experimental paradigms. Overall, increasing age was associated with more signs of anxiety. Additionally, we observed a paradoxical behaviour pattern in aged-subjects that were re-exposed to the EPM, with mid-aged and old rats failing to display open arm avoidance (OAA) in the second trial; this qualitative shift in emotional behaviour was not associated with decreased locomotion. An examination of how age influences responsiveness to anxiolytic drugs, with or without previous maze experience, was also conducted. Midazolam (0.5 and 1 mg/kg) proved anxiolytic in maize-naive young animals; in marked contrast, in older animals midazolam at 1 mg/kg resulted in sedation but not anxiolyis. One trial tolerance to midazolam was evident in animals of both ages that were subjected to a second EPM trial; the latter phenomenon was apparently accentuated in older animals as they do not show open arm avoidance upon re-exposure to the EPM. These data suggest that the age-associated ‘resistance’ to anxiolytic drugs might be related to a qualitative shift in emotional behaviour.ElsevierUniversidade do MinhoBessa, J. M.Oliveira, MárioCerqueira, JoãoAlmeida, O. F. X.Sousa, Nuno2005-07-012005-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/3018eng"Behavioural Brain Research". ISSN 0166-4328. 162:1 (2005) 135-142.0166-432810.1016/j.bbr.2005.03.00515922074http://www.elsevier.com/wps/find/journaldescription.cws_home/506045/description#descriptioninfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:48:27Zoai:repositorium.sdum.uminho.pt:1822/3018Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:46:42.622888Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze |
title |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze |
spellingShingle |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze Bessa, J. M. Aging Anxiety Open arm avoidance One trial tolerance Risk assessment Elevated-plus maze Rat Science & Technology |
title_short |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze |
title_full |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze |
title_fullStr |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze |
title_full_unstemmed |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze |
title_sort |
Age-related qualitative shift in emotional behaviour : paradoxical findings after re-exposure of rats in the elevated-plus maze |
author |
Bessa, J. M. |
author_facet |
Bessa, J. M. Oliveira, Mário Cerqueira, João Almeida, O. F. X. Sousa, Nuno |
author_role |
author |
author2 |
Oliveira, Mário Cerqueira, João Almeida, O. F. X. Sousa, Nuno |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Bessa, J. M. Oliveira, Mário Cerqueira, João Almeida, O. F. X. Sousa, Nuno |
dc.subject.por.fl_str_mv |
Aging Anxiety Open arm avoidance One trial tolerance Risk assessment Elevated-plus maze Rat Science & Technology |
topic |
Aging Anxiety Open arm avoidance One trial tolerance Risk assessment Elevated-plus maze Rat Science & Technology |
description |
Several variables, including age, are known to influence anxiety. Previous exposure to the elevated-plus maze (EPM) is known to modify emotional behaviour as retesting in the EPM at a standard age of 3 months increases open-arm avoidance and attenuates the effects of anxiolytic drugs. This study analysed whether similar results are obtained when older animals are subjected to these experimental paradigms. Overall, increasing age was associated with more signs of anxiety. Additionally, we observed a paradoxical behaviour pattern in aged-subjects that were re-exposed to the EPM, with mid-aged and old rats failing to display open arm avoidance (OAA) in the second trial; this qualitative shift in emotional behaviour was not associated with decreased locomotion. An examination of how age influences responsiveness to anxiolytic drugs, with or without previous maze experience, was also conducted. Midazolam (0.5 and 1 mg/kg) proved anxiolytic in maize-naive young animals; in marked contrast, in older animals midazolam at 1 mg/kg resulted in sedation but not anxiolyis. One trial tolerance to midazolam was evident in animals of both ages that were subjected to a second EPM trial; the latter phenomenon was apparently accentuated in older animals as they do not show open arm avoidance upon re-exposure to the EPM. These data suggest that the age-associated ‘resistance’ to anxiolytic drugs might be related to a qualitative shift in emotional behaviour. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-07-01 2005-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/3018 |
url |
http://hdl.handle.net/1822/3018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"Behavioural Brain Research". ISSN 0166-4328. 162:1 (2005) 135-142. 0166-4328 10.1016/j.bbr.2005.03.005 15922074 http://www.elsevier.com/wps/find/journaldescription.cws_home/506045/description#description |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133037244448768 |