Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690 |
Resumo: | Several cases of paediatric acute hepatitis of an unknown aetiology have been described in these last few months and in several countries worldwide. We present two patients, a 7-month-old girl and an 8-year-old boy, with gastrointestinal symptoms and lethargy, associated with elevation of transaminase levels. Serologies for hepatitis A-E virus and PCR test to SARS-CoV-2 were all negative. In the first case, an adenovirus serotype C could be isolated in a respiratory sample as well as cytomegalovirus (CMV) in the blood (100 copies/mL). In both children, there was a progressive decrease in the hepatic markers and symptomatic resolution, compatible with a good prognosis, also seen globally in most cases. To date, infection remains the most plausible cause to consider, especially when it is presumed to be linked to adenovirus. Other potential agents and causes are still being evaluated, thus emphasizing the importance of continuous epidemiological surveillance, notification, and detailed study of all hepatitis cases. |
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Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese HospitalHepatite Aguda de Origem Desconhecida em Crianças: Dois Casos num Hospital PortuguêsAcute DiseaseChildDisease OutbreaksHepatitisPortugalCriançaDoença AgudaHepatitePortugalSurtos de DoençasSeveral cases of paediatric acute hepatitis of an unknown aetiology have been described in these last few months and in several countries worldwide. We present two patients, a 7-month-old girl and an 8-year-old boy, with gastrointestinal symptoms and lethargy, associated with elevation of transaminase levels. Serologies for hepatitis A-E virus and PCR test to SARS-CoV-2 were all negative. In the first case, an adenovirus serotype C could be isolated in a respiratory sample as well as cytomegalovirus (CMV) in the blood (100 copies/mL). In both children, there was a progressive decrease in the hepatic markers and symptomatic resolution, compatible with a good prognosis, also seen globally in most cases. To date, infection remains the most plausible cause to consider, especially when it is presumed to be linked to adenovirus. Other potential agents and causes are still being evaluated, thus emphasizing the importance of continuous epidemiological surveillance, notification, and detailed study of all hepatitis cases.Casos de hepatite aguda de origem desconhecida têm sido descritos em idade pediátrica nos últimos meses e em vários países por todo o mundo. Apresentamos dois casos, uma lactente de sete meses e uma criança de oito anos, com sintomas gastrointestinais e prostração, associados a elevação das transaminases. As serologias para vírus da hepatite A-E e a pesquisa por PCR de SARS-CoV-2 foram negativas. Na lactente isolou-se adenovírus serotipo C nas secreções respiratórias e citomegalovírus (CMV) no sangue (100 cópias/mL). Em ambos houve uma descida progressiva dos marcadores hepáticos e resolução sintomática, compatível com o bom prognóstico que se tem verificado globalmente na maioria dos casos. A etiologia infeciosa é a hipótese mais plausível, sobretudo a infeção por adenovírus, mas outras causas têm também sido propostas, realçando a importância da vigilância epidemiológica, notificação e estudo detalhado de todos os casos de hepatite.Ordem dos Médicos2023-01-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690Acta Médica Portuguesa; Vol. 36 No. 7-8 (2023): July-August; 506-510Acta Médica Portuguesa; Vol. 36 N.º 7-8 (2023): Julho-Agosto; 506-5101646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690/15181Direitos de Autor (c) 2023 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCraveiro Costa, RicardoSchrempp Esteves, CatarinaFlores, PedroVarandas, Luís2023-07-09T03:00:23Zoai:ojs.www.actamedicaportuguesa.com:article/18690Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:45:54.900700Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital Hepatite Aguda de Origem Desconhecida em Crianças: Dois Casos num Hospital Português |
title |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital |
spellingShingle |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital Craveiro Costa, Ricardo Acute Disease Child Disease Outbreaks Hepatitis Portugal Criança Doença Aguda Hepatite Portugal Surtos de Doenças |
title_short |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital |
title_full |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital |
title_fullStr |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital |
title_full_unstemmed |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital |
title_sort |
Acute Hepatitis of Unknown Origin in Children: Two Cases in a Portuguese Hospital |
author |
Craveiro Costa, Ricardo |
author_facet |
Craveiro Costa, Ricardo Schrempp Esteves, Catarina Flores, Pedro Varandas, Luís |
author_role |
author |
author2 |
Schrempp Esteves, Catarina Flores, Pedro Varandas, Luís |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Craveiro Costa, Ricardo Schrempp Esteves, Catarina Flores, Pedro Varandas, Luís |
dc.subject.por.fl_str_mv |
Acute Disease Child Disease Outbreaks Hepatitis Portugal Criança Doença Aguda Hepatite Portugal Surtos de Doenças |
topic |
Acute Disease Child Disease Outbreaks Hepatitis Portugal Criança Doença Aguda Hepatite Portugal Surtos de Doenças |
description |
Several cases of paediatric acute hepatitis of an unknown aetiology have been described in these last few months and in several countries worldwide. We present two patients, a 7-month-old girl and an 8-year-old boy, with gastrointestinal symptoms and lethargy, associated with elevation of transaminase levels. Serologies for hepatitis A-E virus and PCR test to SARS-CoV-2 were all negative. In the first case, an adenovirus serotype C could be isolated in a respiratory sample as well as cytomegalovirus (CMV) in the blood (100 copies/mL). In both children, there was a progressive decrease in the hepatic markers and symptomatic resolution, compatible with a good prognosis, also seen globally in most cases. To date, infection remains the most plausible cause to consider, especially when it is presumed to be linked to adenovirus. Other potential agents and causes are still being evaluated, thus emphasizing the importance of continuous epidemiological surveillance, notification, and detailed study of all hepatitis cases. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/18690/15181 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2023 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2023 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 36 No. 7-8 (2023): July-August; 506-510 Acta Médica Portuguesa; Vol. 36 N.º 7-8 (2023): Julho-Agosto; 506-510 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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