Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/142200 |
Resumo: | Objective: Describe the pulmonary sequelae of severe COVID-2019 three months after cure. Design: In a prospective cohort study, survivors of COVID-19 who had been admitted to intensive care were assessed in consultation, 3 months after cure, through a validated questionnaire - Severe Respiratory Insufficiency, through a thorax CT scan, and through pulmonary function tests. Setting: Patients admitted to Infectious Diseases Intensive Care Unit of a tertiary Hospital (São João Hospital, Porto, Portugal) discharged alive were invited to be assessed, three months after cure. Patients or participants: Survivors of severe COVID-19 from March to December 2020. Interventions: There are no interventions Main variables of interest: Severe Respiratory Insufficiency-Portuguese score, chest CT scan sequelae, and pulmonary function tests. Results: 58% of the patients had at least one abnormality on the CT-scan. The presence of an active cancer and a lengthier hospitalization were positively associated with the development of chest CT-scan sequelae. Respiratory function tests showed mainly a deficit in the diffusing capacity for carbon monoxide. Clinically, the domain most affected was attendant symptoms and sleep. Females, older patients, and those with comorbidities had lower SRI-PT scores. Conclusions: Most of the patients had chest CT-scan sequelae 3 months after discharge, but a minority had abnormalities in respiratory function tests. The presence of active cancer and a lengthier hospitalization are risk factors to lung sequelae in chest CT-scan. Age, female sex, and comorbidities are risk factors for the permanence of symptomatic sequelae. Patients with severe COVID-19 disease need post-discharge care. |
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Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonarCiências médicas e da saúdeMedical and Health sciencesObjective: Describe the pulmonary sequelae of severe COVID-2019 three months after cure. Design: In a prospective cohort study, survivors of COVID-19 who had been admitted to intensive care were assessed in consultation, 3 months after cure, through a validated questionnaire - Severe Respiratory Insufficiency, through a thorax CT scan, and through pulmonary function tests. Setting: Patients admitted to Infectious Diseases Intensive Care Unit of a tertiary Hospital (São João Hospital, Porto, Portugal) discharged alive were invited to be assessed, three months after cure. Patients or participants: Survivors of severe COVID-19 from March to December 2020. Interventions: There are no interventions Main variables of interest: Severe Respiratory Insufficiency-Portuguese score, chest CT scan sequelae, and pulmonary function tests. Results: 58% of the patients had at least one abnormality on the CT-scan. The presence of an active cancer and a lengthier hospitalization were positively associated with the development of chest CT-scan sequelae. Respiratory function tests showed mainly a deficit in the diffusing capacity for carbon monoxide. Clinically, the domain most affected was attendant symptoms and sleep. Females, older patients, and those with comorbidities had lower SRI-PT scores. Conclusions: Most of the patients had chest CT-scan sequelae 3 months after discharge, but a minority had abnormalities in respiratory function tests. The presence of active cancer and a lengthier hospitalization are risk factors to lung sequelae in chest CT-scan. Age, female sex, and comorbidities are risk factors for the permanence of symptomatic sequelae. Patients with severe COVID-19 disease need post-discharge care.2022-05-122022-05-12T00:00:00Z2024-05-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/142200TID:203178254engLaura Braga de Sousainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:50:37Zoai:repositorio-aberto.up.pt:10216/142200Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:09:50.012812Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar |
title |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar |
spellingShingle |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar Laura Braga de Sousa Ciências médicas e da saúde Medical and Health sciences |
title_short |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar |
title_full |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar |
title_fullStr |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar |
title_full_unstemmed |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar |
title_sort |
Sequelas pulmonares da COVID-19 após recuperação em pacientes críticos: avaliação clínica, radiológica e funcional pulmonar |
author |
Laura Braga de Sousa |
author_facet |
Laura Braga de Sousa |
author_role |
author |
dc.contributor.author.fl_str_mv |
Laura Braga de Sousa |
dc.subject.por.fl_str_mv |
Ciências médicas e da saúde Medical and Health sciences |
topic |
Ciências médicas e da saúde Medical and Health sciences |
description |
Objective: Describe the pulmonary sequelae of severe COVID-2019 three months after cure. Design: In a prospective cohort study, survivors of COVID-19 who had been admitted to intensive care were assessed in consultation, 3 months after cure, through a validated questionnaire - Severe Respiratory Insufficiency, through a thorax CT scan, and through pulmonary function tests. Setting: Patients admitted to Infectious Diseases Intensive Care Unit of a tertiary Hospital (São João Hospital, Porto, Portugal) discharged alive were invited to be assessed, three months after cure. Patients or participants: Survivors of severe COVID-19 from March to December 2020. Interventions: There are no interventions Main variables of interest: Severe Respiratory Insufficiency-Portuguese score, chest CT scan sequelae, and pulmonary function tests. Results: 58% of the patients had at least one abnormality on the CT-scan. The presence of an active cancer and a lengthier hospitalization were positively associated with the development of chest CT-scan sequelae. Respiratory function tests showed mainly a deficit in the diffusing capacity for carbon monoxide. Clinically, the domain most affected was attendant symptoms and sleep. Females, older patients, and those with comorbidities had lower SRI-PT scores. Conclusions: Most of the patients had chest CT-scan sequelae 3 months after discharge, but a minority had abnormalities in respiratory function tests. The presence of active cancer and a lengthier hospitalization are risk factors to lung sequelae in chest CT-scan. Age, female sex, and comorbidities are risk factors for the permanence of symptomatic sequelae. Patients with severe COVID-19 disease need post-discharge care. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-12 2022-05-12T00:00:00Z 2024-05-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/142200 TID:203178254 |
url |
https://hdl.handle.net/10216/142200 |
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TID:203178254 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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