Refractory myasthenia gravis: Characteristics of a portuguese cohort
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/6648 |
Resumo: | Introduction: Some myasthenia gravis (MG) patients are refractory to conventional treatments. Methods: To describe the clinical features of refractory MG (RMG) and explore the association with human leukocyte antigen HLA-DRB1 alleles, a cohort study of 114 consecutive MG patients was performed. Patients were classified as RMG based on predefined criteria. Results: Twenty-two patients were found to have RMG (19.3%). There were no differences between non-RMG and RMG patients with respect to sex, age of onset, abnormal 3-Hz repetitive nerve stimulation, anti-acetylcholine receptor antibody positivity, thymectomy, thymoma or thymic hyperplasia, and polyautoimmunity. HLA-DRB1*03 was more frequent in the non-RMG vs. control population (P = 3 × 10-6 ). The HLA-DRB1*13 allele was less frequent in non-RMG patients compared with controls (P = 0.002), and less frequent in the non-RMG group compared with the RMG group (P = 0.003). Discussion: HLA-DRB1*03 was more common in non-RMG, and the HLA-DRB1*13 allele appeared to have a protective role, as reported previously in other autoimmune disorders. Muscle Nerve 60: 188-191, 2019. |
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Refractory myasthenia gravis: Characteristics of a portuguese cohortAdultAge of OnsetAutoantibodiesCase-Control StudiesCohort StudiesFemaleGenetic Predisposition to DiseaseHLA-DRB1 ChainsHumansMaleMiddle AgedMyasthenia GravisPortugalProtective FactorsReceptors, CholinergicThymectomyThymomaThymus HyperplasiaThymus NeoplasmsYoung AdultDoenças GenéticasIntroduction: Some myasthenia gravis (MG) patients are refractory to conventional treatments. Methods: To describe the clinical features of refractory MG (RMG) and explore the association with human leukocyte antigen HLA-DRB1 alleles, a cohort study of 114 consecutive MG patients was performed. Patients were classified as RMG based on predefined criteria. Results: Twenty-two patients were found to have RMG (19.3%). There were no differences between non-RMG and RMG patients with respect to sex, age of onset, abnormal 3-Hz repetitive nerve stimulation, anti-acetylcholine receptor antibody positivity, thymectomy, thymoma or thymic hyperplasia, and polyautoimmunity. HLA-DRB1*03 was more frequent in the non-RMG vs. control population (P = 3 × 10-6 ). The HLA-DRB1*13 allele was less frequent in non-RMG patients compared with controls (P = 0.002), and less frequent in the non-RMG group compared with the RMG group (P = 0.003). Discussion: HLA-DRB1*03 was more common in non-RMG, and the HLA-DRB1*13 allele appeared to have a protective role, as reported previously in other autoimmune disorders. Muscle Nerve 60: 188-191, 2019.Wiley PeriodicalsRepositório Científico do Instituto Nacional de SaúdeSantos, ErnestinaBettencourt, AndreiaDuarte, SaraGabriel, DenisOliveira, Vanessada Silva, Ana MartinsCosta, Paulo PinhoLopes, CarlosGonçalves, Guilhermeda Silva, Berta MartinsLeite, Maria Isabel2020-05-11T09:32:47Z2019-05-152019-05-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6648engMuscle Nerve. 2019 Aug;60(2):188-191. doi: 10.1002/mus.26507. Epub 2019 May 150148-639X10.1002/mus.26507info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:47Zoai:repositorio.insa.pt:10400.18/6648Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:44.173654Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Refractory myasthenia gravis: Characteristics of a portuguese cohort |
title |
Refractory myasthenia gravis: Characteristics of a portuguese cohort |
spellingShingle |
Refractory myasthenia gravis: Characteristics of a portuguese cohort Santos, Ernestina Adult Age of Onset Autoantibodies Case-Control Studies Cohort Studies Female Genetic Predisposition to Disease HLA-DRB1 Chains Humans Male Middle Aged Myasthenia Gravis Portugal Protective Factors Receptors, Cholinergic Thymectomy Thymoma Thymus Hyperplasia Thymus Neoplasms Young Adult Doenças Genéticas |
title_short |
Refractory myasthenia gravis: Characteristics of a portuguese cohort |
title_full |
Refractory myasthenia gravis: Characteristics of a portuguese cohort |
title_fullStr |
Refractory myasthenia gravis: Characteristics of a portuguese cohort |
title_full_unstemmed |
Refractory myasthenia gravis: Characteristics of a portuguese cohort |
title_sort |
Refractory myasthenia gravis: Characteristics of a portuguese cohort |
author |
Santos, Ernestina |
author_facet |
Santos, Ernestina Bettencourt, Andreia Duarte, Sara Gabriel, Denis Oliveira, Vanessa da Silva, Ana Martins Costa, Paulo Pinho Lopes, Carlos Gonçalves, Guilherme da Silva, Berta Martins Leite, Maria Isabel |
author_role |
author |
author2 |
Bettencourt, Andreia Duarte, Sara Gabriel, Denis Oliveira, Vanessa da Silva, Ana Martins Costa, Paulo Pinho Lopes, Carlos Gonçalves, Guilherme da Silva, Berta Martins Leite, Maria Isabel |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Santos, Ernestina Bettencourt, Andreia Duarte, Sara Gabriel, Denis Oliveira, Vanessa da Silva, Ana Martins Costa, Paulo Pinho Lopes, Carlos Gonçalves, Guilherme da Silva, Berta Martins Leite, Maria Isabel |
dc.subject.por.fl_str_mv |
Adult Age of Onset Autoantibodies Case-Control Studies Cohort Studies Female Genetic Predisposition to Disease HLA-DRB1 Chains Humans Male Middle Aged Myasthenia Gravis Portugal Protective Factors Receptors, Cholinergic Thymectomy Thymoma Thymus Hyperplasia Thymus Neoplasms Young Adult Doenças Genéticas |
topic |
Adult Age of Onset Autoantibodies Case-Control Studies Cohort Studies Female Genetic Predisposition to Disease HLA-DRB1 Chains Humans Male Middle Aged Myasthenia Gravis Portugal Protective Factors Receptors, Cholinergic Thymectomy Thymoma Thymus Hyperplasia Thymus Neoplasms Young Adult Doenças Genéticas |
description |
Introduction: Some myasthenia gravis (MG) patients are refractory to conventional treatments. Methods: To describe the clinical features of refractory MG (RMG) and explore the association with human leukocyte antigen HLA-DRB1 alleles, a cohort study of 114 consecutive MG patients was performed. Patients were classified as RMG based on predefined criteria. Results: Twenty-two patients were found to have RMG (19.3%). There were no differences between non-RMG and RMG patients with respect to sex, age of onset, abnormal 3-Hz repetitive nerve stimulation, anti-acetylcholine receptor antibody positivity, thymectomy, thymoma or thymic hyperplasia, and polyautoimmunity. HLA-DRB1*03 was more frequent in the non-RMG vs. control population (P = 3 × 10-6 ). The HLA-DRB1*13 allele was less frequent in non-RMG patients compared with controls (P = 0.002), and less frequent in the non-RMG group compared with the RMG group (P = 0.003). Discussion: HLA-DRB1*03 was more common in non-RMG, and the HLA-DRB1*13 allele appeared to have a protective role, as reported previously in other autoimmune disorders. Muscle Nerve 60: 188-191, 2019. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-15 2019-05-15T00:00:00Z 2020-05-11T09:32:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6648 |
url |
http://hdl.handle.net/10400.18/6648 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Muscle Nerve. 2019 Aug;60(2):188-191. doi: 10.1002/mus.26507. Epub 2019 May 15 0148-639X 10.1002/mus.26507 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Periodicals |
publisher.none.fl_str_mv |
Wiley Periodicals |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132161764229120 |