Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/7561 |
Resumo: | Three new coordination complexes [Cu-2(phen)(2)(ptz)(4)] (1), [Cu(phen)(pmtz)(2)] (2) and [Cu(phen)(pytz)(2)] (3) (ptz = 5-phenyltetrazolate, pmtz = 5-(2-pyrimidyl)tetrazolate and pytz = 5-(2-pyridyl)tetrazolate) have been synthesized using metal mediated [2+3] cycloaddition reaction between copper bound azide polymer and different organonitriles. All complexes have been structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Complex 1 shows a dinuclear structure via bridging ptz, while 2 and 3 reveal mononuclear structures. These complexes were explored as homogeneous catalysts for the selective peroxidative (with tBuOOH) oxidation of cyclohexane to cyclohexanol and cyclohexanone (KA oil) under very mild and green (solvent-and additive-free) conditions using microwave irradiation. The catecholase-like activity of the synthesized Cu(II) complexes was investigated by employing 3,5-di-tert-butylcatechol (DTBC) as a convenient model substrate, which showed first order kinetics with respect to the substrate in the oxidation of 3,5-di-tert-butyl catechol (DTBC) to 3,5-di-tertbutyl benzoquinone (DTBQ). Further, the interaction of synthesized Cu(II)-tetrazolato complexes with bovine serum albumin (BSA) was studied experimentally as well as through molecular docking to obtain detailed binding information of the Cu(II) complexes with BSA, which revealed higher binding of complex 1 than 2 and 3 |
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Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein bindingCu(II)-tetrazolato complexesCatecholase-like activityKA oilGreen catalystProtein bindingThree new coordination complexes [Cu-2(phen)(2)(ptz)(4)] (1), [Cu(phen)(pmtz)(2)] (2) and [Cu(phen)(pytz)(2)] (3) (ptz = 5-phenyltetrazolate, pmtz = 5-(2-pyrimidyl)tetrazolate and pytz = 5-(2-pyridyl)tetrazolate) have been synthesized using metal mediated [2+3] cycloaddition reaction between copper bound azide polymer and different organonitriles. All complexes have been structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Complex 1 shows a dinuclear structure via bridging ptz, while 2 and 3 reveal mononuclear structures. These complexes were explored as homogeneous catalysts for the selective peroxidative (with tBuOOH) oxidation of cyclohexane to cyclohexanol and cyclohexanone (KA oil) under very mild and green (solvent-and additive-free) conditions using microwave irradiation. The catecholase-like activity of the synthesized Cu(II) complexes was investigated by employing 3,5-di-tert-butylcatechol (DTBC) as a convenient model substrate, which showed first order kinetics with respect to the substrate in the oxidation of 3,5-di-tert-butyl catechol (DTBC) to 3,5-di-tertbutyl benzoquinone (DTBQ). Further, the interaction of synthesized Cu(II)-tetrazolato complexes with bovine serum albumin (BSA) was studied experimentally as well as through molecular docking to obtain detailed binding information of the Cu(II) complexes with BSA, which revealed higher binding of complex 1 than 2 and 3Pergamon-Elsevier ScienceRCIPLSaha, ManideepaVyas, Komal M.Martins, LuisaMartins, Nuno M. R.Pombeiro, ArmandoMobin, Shaikh M.Bhattacherjee, D.Bhabak, Krishna P.Mukhopadhyay, Suman2017-11-20T12:41:10Z2017-082017-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/7561engSAHA, Manideepa [et al] - Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding. Polyhedron. ISSN 0277-5387. Vol.132 (2017), pp. 53-630277-538710.1016/j.poly.2017.04.016metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:53:46Zoai:repositorio.ipl.pt:10400.21/7561Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:16:28.602803Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding |
title |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding |
spellingShingle |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding Saha, Manideepa Cu(II)-tetrazolato complexes Catecholase-like activity KA oil Green catalyst Protein binding |
title_short |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding |
title_full |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding |
title_fullStr |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding |
title_full_unstemmed |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding |
title_sort |
Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding |
author |
Saha, Manideepa |
author_facet |
Saha, Manideepa Vyas, Komal M. Martins, Luisa Martins, Nuno M. R. Pombeiro, Armando Mobin, Shaikh M. Bhattacherjee, D. Bhabak, Krishna P. Mukhopadhyay, Suman |
author_role |
author |
author2 |
Vyas, Komal M. Martins, Luisa Martins, Nuno M. R. Pombeiro, Armando Mobin, Shaikh M. Bhattacherjee, D. Bhabak, Krishna P. Mukhopadhyay, Suman |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Saha, Manideepa Vyas, Komal M. Martins, Luisa Martins, Nuno M. R. Pombeiro, Armando Mobin, Shaikh M. Bhattacherjee, D. Bhabak, Krishna P. Mukhopadhyay, Suman |
dc.subject.por.fl_str_mv |
Cu(II)-tetrazolato complexes Catecholase-like activity KA oil Green catalyst Protein binding |
topic |
Cu(II)-tetrazolato complexes Catecholase-like activity KA oil Green catalyst Protein binding |
description |
Three new coordination complexes [Cu-2(phen)(2)(ptz)(4)] (1), [Cu(phen)(pmtz)(2)] (2) and [Cu(phen)(pytz)(2)] (3) (ptz = 5-phenyltetrazolate, pmtz = 5-(2-pyrimidyl)tetrazolate and pytz = 5-(2-pyridyl)tetrazolate) have been synthesized using metal mediated [2+3] cycloaddition reaction between copper bound azide polymer and different organonitriles. All complexes have been structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Complex 1 shows a dinuclear structure via bridging ptz, while 2 and 3 reveal mononuclear structures. These complexes were explored as homogeneous catalysts for the selective peroxidative (with tBuOOH) oxidation of cyclohexane to cyclohexanol and cyclohexanone (KA oil) under very mild and green (solvent-and additive-free) conditions using microwave irradiation. The catecholase-like activity of the synthesized Cu(II) complexes was investigated by employing 3,5-di-tert-butylcatechol (DTBC) as a convenient model substrate, which showed first order kinetics with respect to the substrate in the oxidation of 3,5-di-tert-butyl catechol (DTBC) to 3,5-di-tertbutyl benzoquinone (DTBQ). Further, the interaction of synthesized Cu(II)-tetrazolato complexes with bovine serum albumin (BSA) was studied experimentally as well as through molecular docking to obtain detailed binding information of the Cu(II) complexes with BSA, which revealed higher binding of complex 1 than 2 and 3 |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-20T12:41:10Z 2017-08 2017-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/7561 |
url |
http://hdl.handle.net/10400.21/7561 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
SAHA, Manideepa [et al] - Copper(II) tetrazolato complexes: Role in oxidation catalysis and protein binding. Polyhedron. ISSN 0277-5387. Vol.132 (2017), pp. 53-63 0277-5387 10.1016/j.poly.2017.04.016 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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