Targeting metabolic reprogramming in acute myeloid leukemia

Detalhes bibliográficos
Autor(a) principal: Castro, Isabel
Data de Publicação: 2019
Outros Autores: Marques, Maria Belém Sousa Sampaio, Ludovico, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61483
Resumo: The cancer metabolic reprogramming allows the maintenance of tumor proliferation, expansion and survival by altering key bioenergetics, biosynthetic and redox functions to meet the higher demands of tumor cells. In addition, several metabolites are also needed to perform signaling functions that further promote tumor growth and progression. These metabolic alterations have been exploited in different cancers, including acute myeloid leukemia, as novel therapeutic strategies both in preclinical models and clinical trials. Here, we review the complexity of acute myeloid leukemia (AML) metabolism and discuss how therapies targeting different aspects of cellular metabolism have demonstrated efficacy and how they provide a therapeutic window that should be explored to target the metabolic requirements of AML cells.
id RCAP_03a854e2886d5f1ad972182f9b1f9dc5
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/61483
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Targeting metabolic reprogramming in acute myeloid leukemiametabolismacute myeloid leukemiapreclinical and clinical trials on metabolic targetsScience & TechnologyThe cancer metabolic reprogramming allows the maintenance of tumor proliferation, expansion and survival by altering key bioenergetics, biosynthetic and redox functions to meet the higher demands of tumor cells. In addition, several metabolites are also needed to perform signaling functions that further promote tumor growth and progression. These metabolic alterations have been exploited in different cancers, including acute myeloid leukemia, as novel therapeutic strategies both in preclinical models and clinical trials. Here, we review the complexity of acute myeloid leukemia (AML) metabolism and discuss how therapies targeting different aspects of cellular metabolism have demonstrated efficacy and how they provide a therapeutic window that should be explored to target the metabolic requirements of AML cells.This research was funded by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, by the European Regional Development Fund (FEDER), through the Competitiveness Factors Operational Programme (COMPETE), grant number NORTE-01-0145-FEDER-000013 and by the projects POCI-01-0145-FEDER-028159 and POCI-01-0145-FEDER-030782 by FEDER, through the COMPETE, and by National funds, through the Foundation for Science and Technology (FCT).Multidisciplinary Digital Publishing InstituteUniversidade do MinhoCastro, IsabelMarques, Maria Belém Sousa SampaioLudovico, Paula2019-08-242019-08-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61483engCastro, I.; Sampaio-Marques, B.; Ludovico, P. Targeting Metabolic Reprogramming in Acute Myeloid Leukemia. Cells 2019, 8, 967.2073-440910.3390/cells809096731450562https://www.mdpi.com/2073-4409/8/9/967info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:01Zoai:repositorium.sdum.uminho.pt:1822/61483Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:52:16.712407Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Targeting metabolic reprogramming in acute myeloid leukemia
title Targeting metabolic reprogramming in acute myeloid leukemia
spellingShingle Targeting metabolic reprogramming in acute myeloid leukemia
Castro, Isabel
metabolism
acute myeloid leukemia
preclinical and clinical trials on metabolic targets
Science & Technology
title_short Targeting metabolic reprogramming in acute myeloid leukemia
title_full Targeting metabolic reprogramming in acute myeloid leukemia
title_fullStr Targeting metabolic reprogramming in acute myeloid leukemia
title_full_unstemmed Targeting metabolic reprogramming in acute myeloid leukemia
title_sort Targeting metabolic reprogramming in acute myeloid leukemia
author Castro, Isabel
author_facet Castro, Isabel
Marques, Maria Belém Sousa Sampaio
Ludovico, Paula
author_role author
author2 Marques, Maria Belém Sousa Sampaio
Ludovico, Paula
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Castro, Isabel
Marques, Maria Belém Sousa Sampaio
Ludovico, Paula
dc.subject.por.fl_str_mv metabolism
acute myeloid leukemia
preclinical and clinical trials on metabolic targets
Science & Technology
topic metabolism
acute myeloid leukemia
preclinical and clinical trials on metabolic targets
Science & Technology
description The cancer metabolic reprogramming allows the maintenance of tumor proliferation, expansion and survival by altering key bioenergetics, biosynthetic and redox functions to meet the higher demands of tumor cells. In addition, several metabolites are also needed to perform signaling functions that further promote tumor growth and progression. These metabolic alterations have been exploited in different cancers, including acute myeloid leukemia, as novel therapeutic strategies both in preclinical models and clinical trials. Here, we review the complexity of acute myeloid leukemia (AML) metabolism and discuss how therapies targeting different aspects of cellular metabolism have demonstrated efficacy and how they provide a therapeutic window that should be explored to target the metabolic requirements of AML cells.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-24
2019-08-24T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61483
url http://hdl.handle.net/1822/61483
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Castro, I.; Sampaio-Marques, B.; Ludovico, P. Targeting Metabolic Reprogramming in Acute Myeloid Leukemia. Cells 2019, 8, 967.
2073-4409
10.3390/cells8090967
31450562
https://www.mdpi.com/2073-4409/8/9/967
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133114566443008

Registros relacionados