Revisiting thyroid hormones in schizophrenia

Detalhes bibliográficos
Autor(a) principal: Santos, Nadine Correia
Data de Publicação: 2012
Outros Autores: Costa, Patrício Soares, Ruano, Dina, Macedo, António, Soares, Maria João, Valente, José, Pereira, Ana Telma, Azevedo, Maria Helena, Palha, Joana Almeida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/22002
Resumo: Thyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosignaling systems involved in schizophrenia’s pathophysiology. These include the serotonergic, dopaminergic, glutamatergic, and GABAergic networks, as well as myelination and inflammatory processes. The available evidence supports that thyroid hormones deregulation is a common feature in schizophrenia and that the implications of thyroid hormones homeostasis in the fine-tuning of crucial brain networks warrants further research.
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spelling Revisiting thyroid hormones in schizophreniaThyroid hormonesSchizophreniaPituitary-thyroid axisScience & TechnologyThyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosignaling systems involved in schizophrenia’s pathophysiology. These include the serotonergic, dopaminergic, glutamatergic, and GABAergic networks, as well as myelination and inflammatory processes. The available evidence supports that thyroid hormones deregulation is a common feature in schizophrenia and that the implications of thyroid hormones homeostasis in the fine-tuning of crucial brain networks warrants further research.The present work was supported by Grant POCI/SAUESP/58757/2004 from the Portuguese Science Foundation (FCT/FEDER). NCS was supported by the fellowship SFRH/ BPD/51057/2010 by FCT.SAGEUniversidade do MinhoSantos, Nadine CorreiaCosta, Patrício SoaresRuano, DinaMacedo, AntónioSoares, Maria JoãoValente, JoséPereira, Ana TelmaAzevedo, Maria HelenaPalha, Joana Almeida2012-032012-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/22002eng2042-007210.1155/2012/569147http://www.hindawi.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T06:45:55Zoai:repositorium.sdum.uminho.pt:1822/22002Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T06:45:55Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Revisiting thyroid hormones in schizophrenia
title Revisiting thyroid hormones in schizophrenia
spellingShingle Revisiting thyroid hormones in schizophrenia
Santos, Nadine Correia
Thyroid hormones
Schizophrenia
Pituitary-thyroid axis
Science & Technology
title_short Revisiting thyroid hormones in schizophrenia
title_full Revisiting thyroid hormones in schizophrenia
title_fullStr Revisiting thyroid hormones in schizophrenia
title_full_unstemmed Revisiting thyroid hormones in schizophrenia
title_sort Revisiting thyroid hormones in schizophrenia
author Santos, Nadine Correia
author_facet Santos, Nadine Correia
Costa, Patrício Soares
Ruano, Dina
Macedo, António
Soares, Maria João
Valente, José
Pereira, Ana Telma
Azevedo, Maria Helena
Palha, Joana Almeida
author_role author
author2 Costa, Patrício Soares
Ruano, Dina
Macedo, António
Soares, Maria João
Valente, José
Pereira, Ana Telma
Azevedo, Maria Helena
Palha, Joana Almeida
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Santos, Nadine Correia
Costa, Patrício Soares
Ruano, Dina
Macedo, António
Soares, Maria João
Valente, José
Pereira, Ana Telma
Azevedo, Maria Helena
Palha, Joana Almeida
dc.subject.por.fl_str_mv Thyroid hormones
Schizophrenia
Pituitary-thyroid axis
Science & Technology
topic Thyroid hormones
Schizophrenia
Pituitary-thyroid axis
Science & Technology
description Thyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosignaling systems involved in schizophrenia’s pathophysiology. These include the serotonergic, dopaminergic, glutamatergic, and GABAergic networks, as well as myelination and inflammatory processes. The available evidence supports that thyroid hormones deregulation is a common feature in schizophrenia and that the implications of thyroid hormones homeostasis in the fine-tuning of crucial brain networks warrants further research.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
2012-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/22002
url http://hdl.handle.net/1822/22002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2042-0072
10.1155/2012/569147
http://www.hindawi.com/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE
publisher.none.fl_str_mv SAGE
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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