Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/147806 |
Resumo: | Funding Information: The study was funded by Foundation for the State of Pernambuco (Process - FACE-04.03/19 ), AP Researcher Research Grant - FACEPE (Process BFP-0038-0 ) and National Council for Scientific and Technological Development grant - CNPq (Process 306865/2020-3 ). This research was also funded by the Foundation for Science and Technology (FCT) through the GHTM ( UID/04413/2020 ). Thanks to MR4, who provided us with the Plasmodium falciparum strains that we used in the assays. We also thank the Laboratory of Magnetic Resonance of the Institute of Chemistry and Biotechnology (Federal University of Alagoas- UFAL) for the analysis of NMR. In addition to these, we would also like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for providing samples of branches and leaves of Buchenavia viridiflora. Publisher Copyright: © 2022 |
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Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applicationsAmazon rainforestBiological activitiesLigninsMacromoleculesStructural BiologyBiochemistryMolecular BiologySDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureFunding Information: The study was funded by Foundation for the State of Pernambuco (Process - FACE-04.03/19 ), AP Researcher Research Grant - FACEPE (Process BFP-0038-0 ) and National Council for Scientific and Technological Development grant - CNPq (Process 306865/2020-3 ). This research was also funded by the Foundation for Science and Technology (FCT) through the GHTM ( UID/04413/2020 ). Thanks to MR4, who provided us with the Plasmodium falciparum strains that we used in the assays. We also thank the Laboratory of Magnetic Resonance of the Institute of Chemistry and Biotechnology (Federal University of Alagoas- UFAL) for the analysis of NMR. In addition to these, we would also like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for providing samples of branches and leaves of Buchenavia viridiflora. Publisher Copyright: © 2022In this work, we investigated in vitro different biological activities of alkaline lignins extracted from the species Buchenavia viridiflora, a tree from the Amazon rainforest used as a wood product. The chemical composition results for the twig and leaves were, respectively (%): cellulose (30.88 and 24. 28), hemicellulose (21.62 and 23.03), lignin (29.93 and 25.46), extractives (13.06 and 20.52), and ash (4.51 and 6.72). The yield was higher for the lignin of the branches (67.9 %) when compared to the leaves (60.2 %). Lignins are of the GSH type, low molecular weight and thermally stable. They promoted moderate to low antioxidant activity, highlighting the lignin of the branches, which presented an IC50 of 884.56 μg/mL for the DPPH assay and an IC50 of 14.08 μg/mL for ABTS. In the cytotoxicity assays, they showed low toxicity against macrophage cells (IC50 28.47 and 22.58 μg/mL). In addition, they were not cytotoxic against splenocytes and erythrocytes at concentrations ranging from 100 to 6.25 μg/mL. These were able to promote splenocyte proliferation and induce the production of anti-inflammatory cytokines. And inhibit the growth of tumor cells with IC50 ranging from 12.63 to values >100 μg/mL and microbial at a concentration of 512 μg/mL. Finally, they showed antiparasitic activity by inhibiting the growth of chloroquine-sensitive and resistant Plasmodium falciparum strains. These findings reinforce that the lignins in this study are promising for potential pharmaceutical and biomedical applications.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)RUNAraújo, Denise Maria Figueiredoda Cruz Filho, Iranildo JoséSantos, TiagoPereira, Daniel Tarciso MartinsMarques, Diego Santa Clarada Conceição Alves de Lima, Alicede Aquino, Thiago Mendonçade Moraes Rocha, George Jacksondo Carmo Alves de Lima, MariaNogueira, Fátima2023-01-18T22:16:42Z2022-10-312022-10-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22application/pdfhttp://hdl.handle.net/10362/147806eng0141-8130PURE: 48275056https://doi.org/10.1016/j.ijbiomac.2022.07.225info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:02Zoai:run.unl.pt:10362/147806Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:05.137694Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications |
| title |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications |
| spellingShingle |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications Araújo, Denise Maria Figueiredo Amazon rainforest Biological activities Lignins Macromolecules Structural Biology Biochemistry Molecular Biology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| title_short |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications |
| title_full |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications |
| title_fullStr |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications |
| title_full_unstemmed |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications |
| title_sort |
Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications |
| author |
Araújo, Denise Maria Figueiredo |
| author_facet |
Araújo, Denise Maria Figueiredo da Cruz Filho, Iranildo José Santos, Tiago Pereira, Daniel Tarciso Martins Marques, Diego Santa Clara da Conceição Alves de Lima, Alice de Aquino, Thiago Mendonça de Moraes Rocha, George Jackson do Carmo Alves de Lima, Maria Nogueira, Fátima |
| author_role |
author |
| author2 |
da Cruz Filho, Iranildo José Santos, Tiago Pereira, Daniel Tarciso Martins Marques, Diego Santa Clara da Conceição Alves de Lima, Alice de Aquino, Thiago Mendonça de Moraes Rocha, George Jackson do Carmo Alves de Lima, Maria Nogueira, Fátima |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) Vector borne diseases and pathogens (VBD) RUN |
| dc.contributor.author.fl_str_mv |
Araújo, Denise Maria Figueiredo da Cruz Filho, Iranildo José Santos, Tiago Pereira, Daniel Tarciso Martins Marques, Diego Santa Clara da Conceição Alves de Lima, Alice de Aquino, Thiago Mendonça de Moraes Rocha, George Jackson do Carmo Alves de Lima, Maria Nogueira, Fátima |
| dc.subject.por.fl_str_mv |
Amazon rainforest Biological activities Lignins Macromolecules Structural Biology Biochemistry Molecular Biology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| topic |
Amazon rainforest Biological activities Lignins Macromolecules Structural Biology Biochemistry Molecular Biology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| description |
Funding Information: The study was funded by Foundation for the State of Pernambuco (Process - FACE-04.03/19 ), AP Researcher Research Grant - FACEPE (Process BFP-0038-0 ) and National Council for Scientific and Technological Development grant - CNPq (Process 306865/2020-3 ). This research was also funded by the Foundation for Science and Technology (FCT) through the GHTM ( UID/04413/2020 ). Thanks to MR4, who provided us with the Plasmodium falciparum strains that we used in the assays. We also thank the Laboratory of Magnetic Resonance of the Institute of Chemistry and Biotechnology (Federal University of Alagoas- UFAL) for the analysis of NMR. In addition to these, we would also like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for providing samples of branches and leaves of Buchenavia viridiflora. Publisher Copyright: © 2022 |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-10-31 2022-10-31T00:00:00Z 2023-01-18T22:16:42Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/147806 |
| url |
http://hdl.handle.net/10362/147806 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0141-8130 PURE: 48275056 https://doi.org/10.1016/j.ijbiomac.2022.07.225 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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22 application/pdf |
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