Toxicometabolomics: small molecules to answer big toxicological questions

Detalhes bibliográficos
Autor(a) principal: Araújo, Ana Margarida
Data de Publicação: 2021
Outros Autores: Carvalho, Félix, Guedes de Pinho, Paula, Carvalho, Márcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/10421
Resumo: Given the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed. In this sense, toxicometabolomics emerged as a new and growing field in life sciences, which use metabolomics to provide new sets of susceptibility, exposure, and/or effects biomarkers; and to characterize in detail the metabolic responses and altered biological pathways that various stressful stimuli cause in many organisms. The present review focuses on the analytical platforms and the typical workflow employed in toxicometabolomic studies, and gives an overview of recent exploratory research that applied metabolomics in various areas of toxicology.
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spelling Toxicometabolomics: small molecules to answer big toxicological questionsToxicometabolomicsDrug toxicityToxicity pathwaysBiomarkersPrediction modelsGiven the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed. In this sense, toxicometabolomics emerged as a new and growing field in life sciences, which use metabolomics to provide new sets of susceptibility, exposure, and/or effects biomarkers; and to characterize in detail the metabolic responses and altered biological pathways that various stressful stimuli cause in many organisms. The present review focuses on the analytical platforms and the typical workflow employed in toxicometabolomic studies, and gives an overview of recent exploratory research that applied metabolomics in various areas of toxicology.MDPIRepositório Institucional da Universidade Fernando PessoaAraújo, Ana MargaridaCarvalho, FélixGuedes de Pinho, PaulaCarvalho, Márcia2021-11-16T11:55:58Z2021-01-01T00:00:00Z2021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/10421eng10.3390/metabo111006922218-1989info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:09:42Zoai:bdigital.ufp.pt:10284/10421Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:47:09.711759Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Toxicometabolomics: small molecules to answer big toxicological questions
title Toxicometabolomics: small molecules to answer big toxicological questions
spellingShingle Toxicometabolomics: small molecules to answer big toxicological questions
Araújo, Ana Margarida
Toxicometabolomics
Drug toxicity
Toxicity pathways
Biomarkers
Prediction models
title_short Toxicometabolomics: small molecules to answer big toxicological questions
title_full Toxicometabolomics: small molecules to answer big toxicological questions
title_fullStr Toxicometabolomics: small molecules to answer big toxicological questions
title_full_unstemmed Toxicometabolomics: small molecules to answer big toxicological questions
title_sort Toxicometabolomics: small molecules to answer big toxicological questions
author Araújo, Ana Margarida
author_facet Araújo, Ana Margarida
Carvalho, Félix
Guedes de Pinho, Paula
Carvalho, Márcia
author_role author
author2 Carvalho, Félix
Guedes de Pinho, Paula
Carvalho, Márcia
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Araújo, Ana Margarida
Carvalho, Félix
Guedes de Pinho, Paula
Carvalho, Márcia
dc.subject.por.fl_str_mv Toxicometabolomics
Drug toxicity
Toxicity pathways
Biomarkers
Prediction models
topic Toxicometabolomics
Drug toxicity
Toxicity pathways
Biomarkers
Prediction models
description Given the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed. In this sense, toxicometabolomics emerged as a new and growing field in life sciences, which use metabolomics to provide new sets of susceptibility, exposure, and/or effects biomarkers; and to characterize in detail the metabolic responses and altered biological pathways that various stressful stimuli cause in many organisms. The present review focuses on the analytical platforms and the typical workflow employed in toxicometabolomic studies, and gives an overview of recent exploratory research that applied metabolomics in various areas of toxicology.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-16T11:55:58Z
2021-01-01T00:00:00Z
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/10421
url http://hdl.handle.net/10284/10421
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3390/metabo11100692
2218-1989
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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