Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/22025 |
Resumo: | Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections. |
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Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides.Antioxidant activityBrazilian propolisFree-radicalsAntibacterialStingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.This work was supported by grants from Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Universidade Federal da Grande Dourados (UFGD), and PRODER (24.073 – Â, Portugal).HindawiBiblioteca Digital do IPBSantos, Cintia MirandaCampos, Jaqueline FerreiraSantos, Jaqueline Freitas dosBalestieri, José Benedito PerrellaSilva, Denise BrentanSouza, Kely de PicoliCarollo, Carlos AlexandreEstevinho, Leticia M.Santos, Edson Lucas dos2020-06-05T09:23:09Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/22025engSantos, Cintia Miranda; Campos, Jaqueline Ferreira; Santos, Jaqueline Freitas dos; Balestieri, José Benedito Perrella; Silva, Denise Brentan; Souza, Kely Picoli; Carollo, Carlos Alexandre; Estevinho, Leticia M.; Santos, Edson Lucas dos (2017). Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity. ISSN 1942-0900. p. 1-131942-090010.1155/2017/83208041942-0994info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:49:38Zoai:bibliotecadigital.ipb.pt:10198/22025Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:13:25.887403Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
title |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
spellingShingle |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. Santos, Cintia Miranda Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
title_short |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
title_full |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
title_fullStr |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
title_full_unstemmed |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
title_sort |
Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. |
author |
Santos, Cintia Miranda |
author_facet |
Santos, Cintia Miranda Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Santos, Edson Lucas dos |
author_role |
author |
author2 |
Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Santos, Edson Lucas dos |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Santos, Cintia Miranda Campos, Jaqueline Ferreira Santos, Jaqueline Freitas dos Balestieri, José Benedito Perrella Silva, Denise Brentan Souza, Kely de Picoli Carollo, Carlos Alexandre Estevinho, Leticia M. Santos, Edson Lucas dos |
dc.subject.por.fl_str_mv |
Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
topic |
Antioxidant activity Brazilian propolis Free-radicals Antibacterial |
description |
Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2020-06-05T09:23:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/22025 |
url |
http://hdl.handle.net/10198/22025 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos, Cintia Miranda; Campos, Jaqueline Ferreira; Santos, Jaqueline Freitas dos; Balestieri, José Benedito Perrella; Silva, Denise Brentan; Souza, Kely Picoli; Carollo, Carlos Alexandre; Estevinho, Leticia M.; Santos, Edson Lucas dos (2017). Chemical composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity. ISSN 1942-0900. p. 1-13 1942-0900 10.1155/2017/8320804 1942-0994 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi |
publisher.none.fl_str_mv |
Hindawi |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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