Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation

Detalhes bibliográficos
Autor(a) principal: Quiroz, César
Data de Publicação: 2006
Outros Autores: Gomes, Catarina, Pak, Arlene C., Ribeiro, Joaquim A., Goldberg, Steven R., Hope, Bruce T., Ferré, Sergi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/8188
Resumo: ©2006 Society for Neuroscience
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spelling Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulationCaffeineAdenosine A2A receptorStriatumPhosphorylationERK1/2AMPA receptor©2006 Society for NeurosciencePrevious studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activation of cAMP– protein kinase A cascade (phosphorylation of the Ser845 residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogenactivated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents. The results indicate that A2A receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons.This work was supported by the Intramural Research Program of the National Institutes of Health, National Institute on Drug Abuse, Department of Health and Human Services.Society for NeuroscienceRepositório da Universidade de LisboaQuiroz, CésarGomes, CatarinaPak, Arlene C.Ribeiro, Joaquim A.Goldberg, Steven R.Hope, Bruce T.Ferré, Sergi2013-04-03T10:34:59Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/8188engThe Journal of Neuroscience, October 18, 2006 • 26(42):10808 –108120270-6474http://dx.doi.org/10.1523/JNEUROSCI.1661-06.2006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:51:54Zoai:repositorio.ul.pt:10451/8188Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:32:48.396048Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
title Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
spellingShingle Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
Quiroz, César
Caffeine
Adenosine A2A receptor
Striatum
Phosphorylation
ERK1/2
AMPA receptor
title_short Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
title_full Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
title_fullStr Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
title_full_unstemmed Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
title_sort Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
author Quiroz, César
author_facet Quiroz, César
Gomes, Catarina
Pak, Arlene C.
Ribeiro, Joaquim A.
Goldberg, Steven R.
Hope, Bruce T.
Ferré, Sergi
author_role author
author2 Gomes, Catarina
Pak, Arlene C.
Ribeiro, Joaquim A.
Goldberg, Steven R.
Hope, Bruce T.
Ferré, Sergi
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Quiroz, César
Gomes, Catarina
Pak, Arlene C.
Ribeiro, Joaquim A.
Goldberg, Steven R.
Hope, Bruce T.
Ferré, Sergi
dc.subject.por.fl_str_mv Caffeine
Adenosine A2A receptor
Striatum
Phosphorylation
ERK1/2
AMPA receptor
topic Caffeine
Adenosine A2A receptor
Striatum
Phosphorylation
ERK1/2
AMPA receptor
description ©2006 Society for Neuroscience
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2013-04-03T10:34:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/8188
url http://hdl.handle.net/10451/8188
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv The Journal of Neuroscience, October 18, 2006 • 26(42):10808 –10812
0270-6474
http://dx.doi.org/10.1523/JNEUROSCI.1661-06.2006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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