Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis

Detalhes bibliográficos
Autor(a) principal: Costa, Daniela
Data de Publicação: 2021
Outros Autores: Cruz, Eduardo B., Silva, Catarina, Canhão, Helena, Branco, Jaime, Nunes, Carla, Rodrigues, Ana M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/133565
Resumo: Funding Information: We thank the EpiDoc Unit and EpiReumaPt team for conceptualising, planning, and implementing the main research project. We would like to acknowledge that the present publication was supported by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Funding Information: This work was supported by an independent research grant from Pfizer. DC received national funding through FCT—Fundação para a Ciência e Tecnologia, I. P. under the Ph.D. grant SFRH/BD/148420/2019
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spelling Factors Associated With Clinical and Radiographic Severity in People With OsteoarthritisA Cross-Sectional Population-Based Studyclinical severityhip osteoarthritisknee osteoarthritisprevalenceradiographic severityMedicine(all)SDG 3 - Good Health and Well-beingFunding Information: We thank the EpiDoc Unit and EpiReumaPt team for conceptualising, planning, and implementing the main research project. We would like to acknowledge that the present publication was supported by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Funding Information: This work was supported by an independent research grant from Pfizer. DC received national funding through FCT—Fundação para a Ciência e Tecnologia, I. P. under the Ph.D. grant SFRH/BD/148420/2019Background: Hip/knee osteoarthritis (HKOA) is a leading cause of disability and imposes a major socioeconomic burden. The aim of this study is to estimate the prevalence of HKOA in Portugal, characterised the clinical severity of HKOA in the population, and identified sociodemographic, lifestyle, and clinical factors associated with higher clinical and radiographic severity. Methods: Participants with a diagnosis of HKOA from the EpiReumaPt study (2011–2013) were included (n = 1,087). Hip/knee osteoarthritis diagnosis was made through a structured evaluation by rheumatologists according to American College of Rheumatology criteria. Clinical severity was classified based on Hip Disability and Osteoarthritis Outcome Scale (HOOS) and Knee Injury and Osteoarthritis Outcome Scale (KOOS) score tertiles. Radiographic severity was classified based on the Kellgren-Lawrence grades as mild, moderate, or severe. Sociodemographic lifestyle and clinical variables, including the presence of anxiety and depression symptoms, were analysed. Factors associated with higher clinical and radiographic severity were identified using ordinal logistic regression models. Results: Hip/knee osteoarthritis diagnosis was present in 14.1% of the Portuguese population [12.4% with knee osteoarthritis (OA) and 2.9% with hip OA]. Clinical severity was similar between people with hip (HOOS = 55.79 ± 20.88) and knee (KOOS = 55.33 ± 20.641) OA. People in the high HOOS/KOOS tertile tended to be older (64.39 ± 0.70 years), female (75.2%), overweight (39.0%) or obese (45.9%), and had multimorbidity (86.1%). Factors significantly associated with higher clinical severity tertile were age [55–64 years: odds ratio (OR) = 3.18; 65–74 years: OR = 3.25; ≥75 years: OR = 4.24], female sex (OR = 1.60), multimorbidity (OR = 1.75), being overweight (OR = 2.01) or obese (OR = 2.82), and having anxiety symptoms (OR = 1.83). Years of education was inversely associated with higher clinical severity. Factors significantly associated with higher radiographic severity were age (65–74 years: OR = 3.59; ≥75 years: OR = 3.05) and being in the high HOOS/KOOS tertile (OR = 4.91). Being a female and live in Lisbon or in the Centre region were inversely associated with the higher radiographic severity. Conclusion: Hip/knee osteoarthritis is present in ~1.1 million of Portuguese people. Age, educational level, and obesity are independently associated with HKOA clinical severity, whereas age, sex, geographic location, and clinical severity are independently associated with radiographic severity.Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNCosta, DanielaCruz, Eduardo B.Silva, CatarinaCanhão, HelenaBranco, JaimeNunes, CarlaRodrigues, Ana M.2022-02-24T23:23:04Z2021-11-152021-11-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/133565eng2296-858XPURE: 41764716https://doi.org/10.3389/fmed.2021.773417info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:12:18Zoai:run.unl.pt:10362/133565Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:50.878473Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
A Cross-Sectional Population-Based Study
title Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
spellingShingle Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
Costa, Daniela
clinical severity
hip osteoarthritis
knee osteoarthritis
prevalence
radiographic severity
Medicine(all)
SDG 3 - Good Health and Well-being
title_short Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
title_full Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
title_fullStr Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
title_full_unstemmed Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
title_sort Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis
author Costa, Daniela
author_facet Costa, Daniela
Cruz, Eduardo B.
Silva, Catarina
Canhão, Helena
Branco, Jaime
Nunes, Carla
Rodrigues, Ana M.
author_role author
author2 Cruz, Eduardo B.
Silva, Catarina
Canhão, Helena
Branco, Jaime
Nunes, Carla
Rodrigues, Ana M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Centro de Investigação em Saúde Pública (CISP/PHRC)
Escola Nacional de Saúde Pública (ENSP)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Costa, Daniela
Cruz, Eduardo B.
Silva, Catarina
Canhão, Helena
Branco, Jaime
Nunes, Carla
Rodrigues, Ana M.
dc.subject.por.fl_str_mv clinical severity
hip osteoarthritis
knee osteoarthritis
prevalence
radiographic severity
Medicine(all)
SDG 3 - Good Health and Well-being
topic clinical severity
hip osteoarthritis
knee osteoarthritis
prevalence
radiographic severity
Medicine(all)
SDG 3 - Good Health and Well-being
description Funding Information: We thank the EpiDoc Unit and EpiReumaPt team for conceptualising, planning, and implementing the main research project. We would like to acknowledge that the present publication was supported by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Funding Information: This work was supported by an independent research grant from Pfizer. DC received national funding through FCT—Fundação para a Ciência e Tecnologia, I. P. under the Ph.D. grant SFRH/BD/148420/2019
publishDate 2021
dc.date.none.fl_str_mv 2021-11-15
2021-11-15T00:00:00Z
2022-02-24T23:23:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/133565
url http://hdl.handle.net/10362/133565
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-858X
PURE: 41764716
https://doi.org/10.3389/fmed.2021.773417
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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