Release of adsorbed ferulic acid in simulated gastrointestinal conditions

Detalhes bibliográficos
Autor(a) principal: Martins, Gonçalo N.
Data de Publicação: 2020
Outros Autores: Spínola, Vítor, Castilho, Paula C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.13/3194
Resumo: Ferulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin (recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confrmed by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can efectively be delivered in the small intestine, after immobilization in solid matrices.
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spelling Release of adsorbed ferulic acid in simulated gastrointestinal conditionsFerulic acidAdsorptionReleaseIn vitro digestion simulationIntestine.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da MadeiraCentro de Química da MadeiraFerulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin (recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confrmed by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can efectively be delivered in the small intestine, after immobilization in solid matrices.SpringerDigitUMaMartins, Gonçalo N.Spínola, VítorCastilho, Paula C.2021-03-24T13:00:34Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/3194engMartins, G. N., Spínola, V., & Castilho, P. C. (2020). Release of adsorbed ferulic acid in simulated gastrointestinal conditions. European Food Research and Technology, 246(6), 1297-1306. https://doi.org/10.1007/s00217-020-03489-w10.1007/s00217-020-03489-winfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-17T05:57:39Zoai:digituma.uma.pt:10400.13/3194Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:08.772389Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Release of adsorbed ferulic acid in simulated gastrointestinal conditions
title Release of adsorbed ferulic acid in simulated gastrointestinal conditions
spellingShingle Release of adsorbed ferulic acid in simulated gastrointestinal conditions
Martins, Gonçalo N.
Ferulic acid
Adsorption
Release
In vitro digestion simulation
Intestine
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
Centro de Química da Madeira
title_short Release of adsorbed ferulic acid in simulated gastrointestinal conditions
title_full Release of adsorbed ferulic acid in simulated gastrointestinal conditions
title_fullStr Release of adsorbed ferulic acid in simulated gastrointestinal conditions
title_full_unstemmed Release of adsorbed ferulic acid in simulated gastrointestinal conditions
title_sort Release of adsorbed ferulic acid in simulated gastrointestinal conditions
author Martins, Gonçalo N.
author_facet Martins, Gonçalo N.
Spínola, Vítor
Castilho, Paula C.
author_role author
author2 Spínola, Vítor
Castilho, Paula C.
author2_role author
author
dc.contributor.none.fl_str_mv DigitUMa
dc.contributor.author.fl_str_mv Martins, Gonçalo N.
Spínola, Vítor
Castilho, Paula C.
dc.subject.por.fl_str_mv Ferulic acid
Adsorption
Release
In vitro digestion simulation
Intestine
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
Centro de Química da Madeira
topic Ferulic acid
Adsorption
Release
In vitro digestion simulation
Intestine
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
Centro de Química da Madeira
description Ferulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin (recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confrmed by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can efectively be delivered in the small intestine, after immobilization in solid matrices.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-03-24T13:00:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.13/3194
url http://hdl.handle.net/10400.13/3194
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins, G. N., Spínola, V., & Castilho, P. C. (2020). Release of adsorbed ferulic acid in simulated gastrointestinal conditions. European Food Research and Technology, 246(6), 1297-1306. https://doi.org/10.1007/s00217-020-03489-w
10.1007/s00217-020-03489-w
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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