Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups

Detalhes bibliográficos
Autor(a) principal: Fernandes, Maria J. G.
Data de Publicação: 2008
Outros Autores: Gonçalves, M. Sameiro T., Costa, Susana P. G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/86532
Resumo: Fluorescent conjugates of N-benzyloxycarbonyl protected gamma-aminobutyric acid were prepared by coupling to its C-terminus several polyheteroaromatic, based on the oxobenzopyran skeleton (trivially known as coumarin) and polyaromatic labels, such as naphthalene and pyrene. Photophysical properties were evaluated, as well as their behaviour towards photocleavage by irradiation in MeOH/HEPES buffer solution (80:20), in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV monitoring.
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spelling Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groupsOxobenzopyranOxobenzobenzopyranCoumarinGamma-aminobutyric acid (GABA)Photocleavable protecting groupsγ-Aminobutyric acid (GABA)Ciências Naturais::Ciências QuímicasScience & TechnologyFluorescent conjugates of N-benzyloxycarbonyl protected gamma-aminobutyric acid were prepared by coupling to its C-terminus several polyheteroaromatic, based on the oxobenzopyran skeleton (trivially known as coumarin) and polyaromatic labels, such as naphthalene and pyrene. Photophysical properties were evaluated, as well as their behaviour towards photocleavage by irradiation in MeOH/HEPES buffer solution (80:20), in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV monitoring.Thanks are due to the Foundation for Science and Technology (Portugal) for financial support through project PTDC/QUI/69607/2006 and a Ph.D. grant to M.J.G.F. (SFRH/BD/36695/2007).Pergamon-Elsevier Science LtdUniversidade do MinhoFernandes, Maria J. G.Gonçalves, M. Sameiro T.Costa, Susana P. G.20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/86532engFernandes, M. J. G., Gonçalves, M. S. T., & Costa, S. P. G. (2008, March). Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups. Tetrahedron. Elsevier BV. http://doi.org/10.1016/j.tet.2008.01.0320040-402010.1016/j.tet.2008.01.032https://www.sciencedirect.com/science/article/pii/S0040402008000574info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-23T01:18:06Zoai:repositorium.sdum.uminho.pt:1822/86532Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:30:35.638528Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
title Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
spellingShingle Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
Fernandes, Maria J. G.
Oxobenzopyran
Oxobenzobenzopyran
Coumarin
Gamma-aminobutyric acid (GABA)
Photocleavable protecting groups
γ-Aminobutyric acid (GABA)
Ciências Naturais::Ciências Químicas
Science & Technology
title_short Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
title_full Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
title_fullStr Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
title_full_unstemmed Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
title_sort Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups
author Fernandes, Maria J. G.
author_facet Fernandes, Maria J. G.
Gonçalves, M. Sameiro T.
Costa, Susana P. G.
author_role author
author2 Gonçalves, M. Sameiro T.
Costa, Susana P. G.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fernandes, Maria J. G.
Gonçalves, M. Sameiro T.
Costa, Susana P. G.
dc.subject.por.fl_str_mv Oxobenzopyran
Oxobenzobenzopyran
Coumarin
Gamma-aminobutyric acid (GABA)
Photocleavable protecting groups
γ-Aminobutyric acid (GABA)
Ciências Naturais::Ciências Químicas
Science & Technology
topic Oxobenzopyran
Oxobenzobenzopyran
Coumarin
Gamma-aminobutyric acid (GABA)
Photocleavable protecting groups
γ-Aminobutyric acid (GABA)
Ciências Naturais::Ciências Químicas
Science & Technology
description Fluorescent conjugates of N-benzyloxycarbonyl protected gamma-aminobutyric acid were prepared by coupling to its C-terminus several polyheteroaromatic, based on the oxobenzopyran skeleton (trivially known as coumarin) and polyaromatic labels, such as naphthalene and pyrene. Photophysical properties were evaluated, as well as their behaviour towards photocleavage by irradiation in MeOH/HEPES buffer solution (80:20), in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV monitoring.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/86532
url https://hdl.handle.net/1822/86532
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes, M. J. G., Gonçalves, M. S. T., & Costa, S. P. G. (2008, March). Comparative study of polyaromatic and polyheteroaromatic fluorescent photocleavable protecting groups. Tetrahedron. Elsevier BV. http://doi.org/10.1016/j.tet.2008.01.032
0040-4020
10.1016/j.tet.2008.01.032
https://www.sciencedirect.com/science/article/pii/S0040402008000574
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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