Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications.
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215 |
Resumo: | In what concerns women and children infected with HIV, clinical investigation related ethical issues are both unavoidable and controversial. Different arguments are presented by different partners, and policies and laws are made in order to protect women and children, who, in spite of all that, keep suffering the effects of all this controversy, protection and legislation. Evidence based Medicine is responsible for new and demanding challenges and the same ethics that requires that new drugs are used only after unquestionable safety and efficacy are presented, tends to protect children, pregnant women and other vulnerable groups from being exposed to investigational drugs. This is why there are so few therapeutical options for HIV-infected children and pregnant women. So, ironically, in times of evidence based medicine, these two special populations are treated in an empirical way, because the same Medicine that wants to protect them, offers wide-open doors to the most terrible infections that mankind has ever faced. In this article, ethical dilemmas, philosophical principles, epidemiological context and different perspectives concerning this painful, yet extremely important, subject will be presented. The purposes will be to broaden horizons, to stimulate discussion and to provide some light into a subject still so restrict, still so unspoken, still so left in the shadows of something that we like to describe as modern medicine. |
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Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications.A gravidez, a criança, os estudos clínicos e a infecção pelo VIH. Limitações éticas e implicações terapêuticas.In what concerns women and children infected with HIV, clinical investigation related ethical issues are both unavoidable and controversial. Different arguments are presented by different partners, and policies and laws are made in order to protect women and children, who, in spite of all that, keep suffering the effects of all this controversy, protection and legislation. Evidence based Medicine is responsible for new and demanding challenges and the same ethics that requires that new drugs are used only after unquestionable safety and efficacy are presented, tends to protect children, pregnant women and other vulnerable groups from being exposed to investigational drugs. This is why there are so few therapeutical options for HIV-infected children and pregnant women. So, ironically, in times of evidence based medicine, these two special populations are treated in an empirical way, because the same Medicine that wants to protect them, offers wide-open doors to the most terrible infections that mankind has ever faced. In this article, ethical dilemmas, philosophical principles, epidemiological context and different perspectives concerning this painful, yet extremely important, subject will be presented. The purposes will be to broaden horizons, to stimulate discussion and to provide some light into a subject still so restrict, still so unspoken, still so left in the shadows of something that we like to describe as modern medicine.In what concerns women and children infected with HIV, clinical investigation related ethical issues are both unavoidable and controversial. Different arguments are presented by different partners, and policies and laws are made in order to protect women and children, who, in spite of all that, keep suffering the effects of all this controversy, protection and legislation. Evidence based Medicine is responsible for new and demanding challenges and the same ethics that requires that new drugs are used only after unquestionable safety and efficacy are presented, tends to protect children, pregnant women and other vulnerable groups from being exposed to investigational drugs. This is why there are so few therapeutical options for HIV-infected children and pregnant women. So, ironically, in times of evidence based medicine, these two special populations are treated in an empirical way, because the same Medicine that wants to protect them, offers wide-open doors to the most terrible infections that mankind has ever faced. In this article, ethical dilemmas, philosophical principles, epidemiological context and different perspectives concerning this painful, yet extremely important, subject will be presented. The purposes will be to broaden horizons, to stimulate discussion and to provide some light into a subject still so restrict, still so unspoken, still so left in the shadows of something that we like to describe as modern medicine.Ordem dos Médicos2003-12-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215oai:ojs.www.actamedicaportuguesa.com:article/1215Acta Médica Portuguesa; Vol. 16 No. 6 (2003): November-December; 437-46Acta Médica Portuguesa; Vol. 16 N.º 6 (2003): Novembro-Dezembro; 437-461646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215/867Gouveia-Andrade, Luísinfo:eu-repo/semantics/openAccess2022-12-20T10:57:39Zoai:ojs.www.actamedicaportuguesa.com:article/1215Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:02.448059Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. A gravidez, a criança, os estudos clínicos e a infecção pelo VIH. Limitações éticas e implicações terapêuticas. |
title |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. |
spellingShingle |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. Gouveia-Andrade, Luís |
title_short |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. |
title_full |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. |
title_fullStr |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. |
title_full_unstemmed |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. |
title_sort |
Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications. |
author |
Gouveia-Andrade, Luís |
author_facet |
Gouveia-Andrade, Luís |
author_role |
author |
dc.contributor.author.fl_str_mv |
Gouveia-Andrade, Luís |
description |
In what concerns women and children infected with HIV, clinical investigation related ethical issues are both unavoidable and controversial. Different arguments are presented by different partners, and policies and laws are made in order to protect women and children, who, in spite of all that, keep suffering the effects of all this controversy, protection and legislation. Evidence based Medicine is responsible for new and demanding challenges and the same ethics that requires that new drugs are used only after unquestionable safety and efficacy are presented, tends to protect children, pregnant women and other vulnerable groups from being exposed to investigational drugs. This is why there are so few therapeutical options for HIV-infected children and pregnant women. So, ironically, in times of evidence based medicine, these two special populations are treated in an empirical way, because the same Medicine that wants to protect them, offers wide-open doors to the most terrible infections that mankind has ever faced. In this article, ethical dilemmas, philosophical principles, epidemiological context and different perspectives concerning this painful, yet extremely important, subject will be presented. The purposes will be to broaden horizons, to stimulate discussion and to provide some light into a subject still so restrict, still so unspoken, still so left in the shadows of something that we like to describe as modern medicine. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-12-31 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215 oai:ojs.www.actamedicaportuguesa.com:article/1215 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215 |
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oai:ojs.www.actamedicaportuguesa.com:article/1215 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1215/867 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Ordem dos Médicos |
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Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 16 No. 6 (2003): November-December; 437-46 Acta Médica Portuguesa; Vol. 16 N.º 6 (2003): Novembro-Dezembro; 437-46 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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