Beyond killing: Can we find new ways to manage infection?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/760 |
Resumo: | This deposit is composed by the main article, and hasn't not associated any supplementary materials of the publication. |
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Beyond killing: Can we find new ways to manage infection?infectionanti-virulence drugsdamage limitationdisease tolerancemicrobiotaevolutionThis deposit is composed by the main article, and hasn't not associated any supplementary materials of the publication.The antibiotic pipeline is running dry and infectious disease remains a major threat to public health. An efficient strategy to stay ahead of rapidly adapting pathogens should include approaches that replace, complement or enhance the effect of both current and novel antimicrobial compounds. In recent years, a number of innovative approaches to manage disease without the aid of traditional antibiotics and without eliminating the pathogens directly have emerged. These include disabling pathogen virulence-factors, increasing host tissue damage control or altering the microbiota to provide colonization resistance, immune resistance or disease tolerance against pathogens. We discuss the therapeutic potential of these approaches and examine their possible consequences for pathogen evolution. To guarantee a longer half-life of these alternatives to directly killing pathogens, and to gain a full understanding of their population-level consequences, we encourage future work to incorporate evolutionary perspectives into the development of these treatments.Wellcome Trust for the Centre for Immunity, Infection and Evolution grant: (095831); ETH Zürich fellowship: (Society in Science—Branco Weiss); Human Frontier Science Programme grant: (HFSP RGP0011/2014); Fundação Calouste Gulbenkian; Fundação para a Ciência e Tecnologia grants: (PTDC/SAU TOX/116627/2010, HMSP-ICT/0022/2010); ERC 7th Framework grant: (ERC-2011-AdG.294709-DAMAGECONTROL); BSRC Institute Strategic Programme grant: (ISP1); Swiss National Science Foundation grant: (PP00P3-139164); Novartis Foundation for medical and biological research.Oxford University PressARCAVale, Pedro F.McNally, LukeDoeschl-Wilson, AndreaKing, Kayla C.Popat, RomanDomingo-Sananes, Maria R.Allen, Judith E.Soares, Miguel P.Kümmerli, Rolf2017-05-25T14:42:02Z2016-03-252016-03-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/760engPedro F. Vale, Luke McNally, Andrea Doeschl-Wilson, Kayla C. King, Roman Popat, Maria R. Domingo-Sananes, Judith E. Allen, Miguel P. Soares, Rolf Kümmerli; Beyond killing: Can we find new ways to manage infection?. Evol Med Public Health 2016; 2016 (1): 148-157. doi: 10.1093/emph/eow01210.1093/emph/eow012info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:09Zoai:arca.igc.gulbenkian.pt:10400.7/760Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:59.180640Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Beyond killing: Can we find new ways to manage infection? |
| title |
Beyond killing: Can we find new ways to manage infection? |
| spellingShingle |
Beyond killing: Can we find new ways to manage infection? Vale, Pedro F. infection anti-virulence drugs damage limitation disease tolerance microbiota evolution |
| title_short |
Beyond killing: Can we find new ways to manage infection? |
| title_full |
Beyond killing: Can we find new ways to manage infection? |
| title_fullStr |
Beyond killing: Can we find new ways to manage infection? |
| title_full_unstemmed |
Beyond killing: Can we find new ways to manage infection? |
| title_sort |
Beyond killing: Can we find new ways to manage infection? |
| author |
Vale, Pedro F. |
| author_facet |
Vale, Pedro F. McNally, Luke Doeschl-Wilson, Andrea King, Kayla C. Popat, Roman Domingo-Sananes, Maria R. Allen, Judith E. Soares, Miguel P. Kümmerli, Rolf |
| author_role |
author |
| author2 |
McNally, Luke Doeschl-Wilson, Andrea King, Kayla C. Popat, Roman Domingo-Sananes, Maria R. Allen, Judith E. Soares, Miguel P. Kümmerli, Rolf |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Vale, Pedro F. McNally, Luke Doeschl-Wilson, Andrea King, Kayla C. Popat, Roman Domingo-Sananes, Maria R. Allen, Judith E. Soares, Miguel P. Kümmerli, Rolf |
| dc.subject.por.fl_str_mv |
infection anti-virulence drugs damage limitation disease tolerance microbiota evolution |
| topic |
infection anti-virulence drugs damage limitation disease tolerance microbiota evolution |
| description |
This deposit is composed by the main article, and hasn't not associated any supplementary materials of the publication. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-03-25 2016-03-25T00:00:00Z 2017-05-25T14:42:02Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/760 |
| url |
http://hdl.handle.net/10400.7/760 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Pedro F. Vale, Luke McNally, Andrea Doeschl-Wilson, Kayla C. King, Roman Popat, Maria R. Domingo-Sananes, Judith E. Allen, Miguel P. Soares, Rolf Kümmerli; Beyond killing: Can we find new ways to manage infection?. Evol Med Public Health 2016; 2016 (1): 148-157. doi: 10.1093/emph/eow012 10.1093/emph/eow012 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Oxford University Press |
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Oxford University Press |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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