Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study

Detalhes bibliográficos
Autor(a) principal: Picolo, Marta
Data de Publicação: 2023
Outros Autores: Nobre, Miguel de Araújo, Salvado, Francisco, Barroso, Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/58210
Resumo: © 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
id RCAP_06381da940f76f5d704036be379f90b7
oai_identifier_str oai:repositorio.ul.pt:10451/58210
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Association of herpesvirus and periodontitis: a clinical and laboratorial case-control studyPeriodontitisHerpes simplex virusEpstein-Barr virusCytomegalovirusEpidemiology© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)Objectives: A significant influence of the Herpesviridae family in the progression of periodontal disease has been suggested. The aim of this study was to investigate the potential association of four Herpesviruses (HSV-1, HSV-2, cytomegalovirus [CMV], and Epstein-Barr virus [EBV]) with periodontal disease using a qualitative test for evaluating the presence or absence of viral DNA in crevicular fluid samples of both healthy periodontal patients and periodontal compromised patients. Materials and methods: A case-control study was conducted in 100 participants at a university clinic. A qualitative test was used for evaluating the presence/absence of viral DNA in crevicular fluid samples of both healthy periodontal patients and periodontal compromised patients, and considering the periodontitis staging (stage II, stage III, and stage IV) and grading (grade A, grade B, and grade C). Statistical analysis: The distribution of the same exposure variables to the periodontitis staging and grading was compared using Chi-square, Fisher's exact, and Gamma tests depending on the variable characteristics. The significance level was set at 5%. The association of the variables: age, sex, diabetes, smoking, alcohol, and oral hygiene was also considered. Results: The prevalence of Herpesviridae family virus DNA was 6% for the periodontal healthy group and 60% for the periodontitis group (roughly 60% on periodontitis stages II, III, and IV, p <0.001; and twofold increase in moderate and rapid progression grades compared with the slow progression grade, p <0.001). HSV1 DNA was prevalent in all periodontitis stages and grades. HSV 2, EBV, and CMV DNA had increasing prevalence rates in more severe stages (stages III and IV, p <0.001); while considering periodontitis grade, HSV2 (p = 0.001), CMV (p = 0.019) and EBV (p <0.001) DNA were prevalent only in grades B and C, with EBV DNA registering a marked prevalence in grade C. Conclusion: A significant different distribution of Herpesviridae virus DNA per each stage of disease was registered.Georg Thieme Verlag KGRepositório da Universidade de LisboaPicolo, MartaNobre, Miguel de AraújoSalvado, FranciscoBarroso, Helena2023-06-14T14:38:06Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58210engEur J Dent. 2023 Jun 91305-745610.1055/s-0043-17614231305-7464info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:57Zoai:repositorio.ul.pt:10451/58210Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:31.183789Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
title Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
spellingShingle Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
Picolo, Marta
Periodontitis
Herpes simplex virus
Epstein-Barr virus
Cytomegalovirus
Epidemiology
title_short Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
title_full Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
title_fullStr Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
title_full_unstemmed Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
title_sort Association of herpesvirus and periodontitis: a clinical and laboratorial case-control study
author Picolo, Marta
author_facet Picolo, Marta
Nobre, Miguel de Araújo
Salvado, Francisco
Barroso, Helena
author_role author
author2 Nobre, Miguel de Araújo
Salvado, Francisco
Barroso, Helena
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Picolo, Marta
Nobre, Miguel de Araújo
Salvado, Francisco
Barroso, Helena
dc.subject.por.fl_str_mv Periodontitis
Herpes simplex virus
Epstein-Barr virus
Cytomegalovirus
Epidemiology
topic Periodontitis
Herpes simplex virus
Epstein-Barr virus
Cytomegalovirus
Epidemiology
description © 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
publishDate 2023
dc.date.none.fl_str_mv 2023-06-14T14:38:06Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/58210
url http://hdl.handle.net/10451/58210
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Dent. 2023 Jun 9
1305-7456
10.1055/s-0043-1761423
1305-7464
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag KG
publisher.none.fl_str_mv Georg Thieme Verlag KG
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134639608037376

Registros relacionados