Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/13816 |
Resumo: | Introduction: The use of perioperative chemotherapy (CT) in patients with advanced gastric carcinoma increases their overall survival. This therapy may also increase the number of patients with R0 resection. Potential drawbacks of this therapy, besides its toxicity, include increased surgical morbidity. Methods: We retrospectively evaluated the records of patients undergoing gastrectomy with curative intent, for carcinoma, at our institution between January 2009 and August 2018. They were divided into two groups: direct surgery (SURG) and perioperative CT (CHEMO). Patients with other neoadjuvant therapies and cardia Siewert I and II carcinomas were excluded. The primary objective was to evaluate the impact of perioperative CT on surgical morbidity. As secondary objectives, resection radicality and total lymph node count were compared between the two groups. Results: A total of 307 patients (97 direct surgery and 210 perioperative CT) were evaluated. Median age was 67 years old. The overall major surgical morbidity (Clavien-Dindo 3-5) was 10.6% in the CHEMO group and 12.4 in the SURG group (p = 0.643). There was no statistically significant difference between the surgical radicality (R0 98% in the SURG group vs 97.5% CHEMO group (p = 0.865). There was an increase in the total number of lymph nodes retrieved in the specimen in the CHEMO group (25 vs 22, p = 0.001), a difference that was not maintained in the subgroup analysis as a function of the surgery performed. Conclusions: Perioperative CT in gastric carcinoma does not increase surgical morbidity, surgical radicality and total lymph node count. (C) 2020 AEC. Published by Elsevier Espana, S.L.U. All rights reserved. |
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Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancerGastric cancerGastrectomyPerioperative chemotherapySurgical morbidityCáncer gástricoGastrectomíaQuimioterapia perioperatoriaMorbilidad quirúrgicaIntroduction: The use of perioperative chemotherapy (CT) in patients with advanced gastric carcinoma increases their overall survival. This therapy may also increase the number of patients with R0 resection. Potential drawbacks of this therapy, besides its toxicity, include increased surgical morbidity. Methods: We retrospectively evaluated the records of patients undergoing gastrectomy with curative intent, for carcinoma, at our institution between January 2009 and August 2018. They were divided into two groups: direct surgery (SURG) and perioperative CT (CHEMO). Patients with other neoadjuvant therapies and cardia Siewert I and II carcinomas were excluded. The primary objective was to evaluate the impact of perioperative CT on surgical morbidity. As secondary objectives, resection radicality and total lymph node count were compared between the two groups. Results: A total of 307 patients (97 direct surgery and 210 perioperative CT) were evaluated. Median age was 67 years old. The overall major surgical morbidity (Clavien-Dindo 3-5) was 10.6% in the CHEMO group and 12.4 in the SURG group (p = 0.643). There was no statistically significant difference between the surgical radicality (R0 98% in the SURG group vs 97.5% CHEMO group (p = 0.865). There was an increase in the total number of lymph nodes retrieved in the specimen in the CHEMO group (25 vs 22, p = 0.001), a difference that was not maintained in the subgroup analysis as a function of the surgery performed. Conclusions: Perioperative CT in gastric carcinoma does not increase surgical morbidity, surgical radicality and total lymph node count. (C) 2020 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.Introducción: El uso de quimioterapia perioperatoria (QT) en pacientes con carcinoma gástrico avanzado aumenta su supervivencia. Esta terapia también puede aumentar el número de pacientes con resección R0. Entre los posibles inconvenientes de esta terapia, además desu toxicidad, está una mayor morbilidad quirúrgica.El objetivo principal fue evaluar el impacto de la QT perioperatoria en la morbilidadquirúrgica. Como objetivos secundarios, la radicalidad de la resección y el recuento total deganglios linfáticos, que se compararon entre los dos grupos. Métodos: Evaluamos retrospectivamente los registros de pacientes sometidos a gastrectomía con intención curativa para carcinoma, en nuestra institución, entre enero de 2009 yagosto de 2018. Se dividieron en dos grupos: cirugía directa (SURG) y QT perioperatoria(CHEMO).Se evaluóun total de 307 pacientes (97 SURG y 210 CHEMO). La mediana de edad fue de67 anos.Resultados: La morbilidad quirúrgica mayor (Clavien-Dindo 3-5) fue de 10,6% en el grupoCHEMO y de 12,4 en el grupo SURG (p = 0,643).No hubo diferencias estadísticamente significativas entre el radical quirúrgico (R0 98% enel grupo de SURG vs. 97,5% del grupo CHEMO (p = 0,865). Hubo un aumento en el número totalde ganglios linfáticos recuperados en la muestra en el grupo CHEMO (25 vs. 22, p = 0,001), unadiferencia que no se mantuvo en el análisis de subgrupos en función de la cirugía realizada.Conclusiones: La QT perioperatoria en el carcinoma gástrico no aumenta la morbilidadquirúrgica, la radicalidad quirúrgica y el recuento total de ganglios linfáticos.Elsevier EspanaRCIPLCabral, FranciscoRamos, PauloMonteiro, CecíliaCasaca, RuiPinto, IolaAbecasis, Nuno2021-10-01T15:02:29Z2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13816engCABRAL, Francisco; [et al] – Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer. Cirugia Espanola. ISSN 0009-739X. Vol. 99, N.º 7 (2021), pp. 521-5260009-739X10.1016/j.ciresp.2020.09.0061578-147Xmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:09:10Zoai:repositorio.ipl.pt:10400.21/13816Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:41.813752Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer |
title |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer |
spellingShingle |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer Cabral, Francisco Gastric cancer Gastrectomy Perioperative chemotherapy Surgical morbidity Cáncer gástrico Gastrectomía Quimioterapia perioperatoria Morbilidad quirúrgica |
title_short |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer |
title_full |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer |
title_fullStr |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer |
title_full_unstemmed |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer |
title_sort |
Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer |
author |
Cabral, Francisco |
author_facet |
Cabral, Francisco Ramos, Paulo Monteiro, Cecília Casaca, Rui Pinto, Iola Abecasis, Nuno |
author_role |
author |
author2 |
Ramos, Paulo Monteiro, Cecília Casaca, Rui Pinto, Iola Abecasis, Nuno |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Cabral, Francisco Ramos, Paulo Monteiro, Cecília Casaca, Rui Pinto, Iola Abecasis, Nuno |
dc.subject.por.fl_str_mv |
Gastric cancer Gastrectomy Perioperative chemotherapy Surgical morbidity Cáncer gástrico Gastrectomía Quimioterapia perioperatoria Morbilidad quirúrgica |
topic |
Gastric cancer Gastrectomy Perioperative chemotherapy Surgical morbidity Cáncer gástrico Gastrectomía Quimioterapia perioperatoria Morbilidad quirúrgica |
description |
Introduction: The use of perioperative chemotherapy (CT) in patients with advanced gastric carcinoma increases their overall survival. This therapy may also increase the number of patients with R0 resection. Potential drawbacks of this therapy, besides its toxicity, include increased surgical morbidity. Methods: We retrospectively evaluated the records of patients undergoing gastrectomy with curative intent, for carcinoma, at our institution between January 2009 and August 2018. They were divided into two groups: direct surgery (SURG) and perioperative CT (CHEMO). Patients with other neoadjuvant therapies and cardia Siewert I and II carcinomas were excluded. The primary objective was to evaluate the impact of perioperative CT on surgical morbidity. As secondary objectives, resection radicality and total lymph node count were compared between the two groups. Results: A total of 307 patients (97 direct surgery and 210 perioperative CT) were evaluated. Median age was 67 years old. The overall major surgical morbidity (Clavien-Dindo 3-5) was 10.6% in the CHEMO group and 12.4 in the SURG group (p = 0.643). There was no statistically significant difference between the surgical radicality (R0 98% in the SURG group vs 97.5% CHEMO group (p = 0.865). There was an increase in the total number of lymph nodes retrieved in the specimen in the CHEMO group (25 vs 22, p = 0.001), a difference that was not maintained in the subgroup analysis as a function of the surgery performed. Conclusions: Perioperative CT in gastric carcinoma does not increase surgical morbidity, surgical radicality and total lymph node count. (C) 2020 AEC. Published by Elsevier Espana, S.L.U. All rights reserved. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-01T15:02:29Z 2021-08 2021-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/13816 |
url |
http://hdl.handle.net/10400.21/13816 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
CABRAL, Francisco; [et al] – Impact of perioperative chemotherapy on postoperative morbidity after gastrectomy for gastric cancer. Cirugia Espanola. ISSN 0009-739X. Vol. 99, N.º 7 (2021), pp. 521-526 0009-739X 10.1016/j.ciresp.2020.09.006 1578-147X |
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metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Espana |
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Elsevier Espana |
dc.source.none.fl_str_mv |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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