Distinction and prognosis of early arthritis phenotypes

Detalhes bibliográficos
Autor(a) principal: Sepriano, Alexandre
Data de Publicação: 2023
Outros Autores: van Dijk, Bastiaan, Ramiro, Sofia, van der Helm-van Mil, Annette, Combe, Bernard, van Schaardenburg, Dirkjan, de Wit, Maarten, Kent, Alison, Mateus, Elsa, Landewé, Robert
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/160664
Resumo: Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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spelling Distinction and prognosis of early arthritis phenotypesan analysis in three European cohortsArthritis, RheumatoidMagnetic Resonance ImagingOutcome and Process Assessment, Health CareRheumatologyImmunology and AllergyImmunologyPublisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES: The objective of this study is to evaluate whether there are differences in the long-term prognosis across various phenotypes of early arthritis (EA). METHODS: Three EA cohorts (Reade, Etude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR) and Early Arthritis Clinic (EAC)) were analysed. Clinical data were collected up to 24 years. Hands and feet radiographs were scored according to the Sharp van der Heijde (SvdH) method. Latent class analysis was applied to determine the EA phenotypes at baseline. Each class received a label reflecting its most prominent features. Prognostic outcomes included Health Assessment Questionnaire (HAQ), Short Form 36 (SF36) and SvdH score. The association between class membership and outcomes over time was tested in multivariable models. RESULTS: In total, 390 (Reade), 798 (ESPOIR) and 3991 (EAC) patients were analysed separately. Two classes with symmetrical polyarthritis emerged; one of these labelled as autoimmune inflammatory polyarthritis (AIPA), had high likelihood of acute phase reactants (APR) elevation and autoantibody positivity, while the other (mild-inflammatory polyarthritis; MIPA) had not. A third class had oligoarthritis of upper limbs (OAUL) and could be subdivided into autoimmune OAUL and mild-inflammatory OAUL. A fifth class had oligoarthritis of lower limbs. The SvdH scores were worse in patients with APR/autoantibodies (AIPA) than in those without (MIPA). No clinically meaningful differences across classes in HAQ or SF36 over time were found. CONCLUSION: Radiographic progression over time primarily occurs in EA patients with APR/autoantibodies. The absence of these markers, however, does not necessarily translate into better long-term function and quality of life. Clinicians should not only aim at preventing joint damage, but look beyond structural progression in order to further improve the lives of people with EA.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSepriano, Alexandrevan Dijk, BastiaanRamiro, Sofiavan der Helm-van Mil, AnnetteCombe, Bernardvan Schaardenburg, Dirkjande Wit, MaartenKent, AlisonMateus, ElsaLandewé, Robert2023-11-28T22:37:18Z2023-11-012023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/160664eng2044-6055PURE: 76186590https://doi.org/10.1136/rmdopen-2023-003611info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:43:24Zoai:run.unl.pt:10362/160664Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:09.574109Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Distinction and prognosis of early arthritis phenotypes
an analysis in three European cohorts
title Distinction and prognosis of early arthritis phenotypes
spellingShingle Distinction and prognosis of early arthritis phenotypes
Sepriano, Alexandre
Arthritis, Rheumatoid
Magnetic Resonance Imaging
Outcome and Process Assessment, Health Care
Rheumatology
Immunology and Allergy
Immunology
title_short Distinction and prognosis of early arthritis phenotypes
title_full Distinction and prognosis of early arthritis phenotypes
title_fullStr Distinction and prognosis of early arthritis phenotypes
title_full_unstemmed Distinction and prognosis of early arthritis phenotypes
title_sort Distinction and prognosis of early arthritis phenotypes
author Sepriano, Alexandre
author_facet Sepriano, Alexandre
van Dijk, Bastiaan
Ramiro, Sofia
van der Helm-van Mil, Annette
Combe, Bernard
van Schaardenburg, Dirkjan
de Wit, Maarten
Kent, Alison
Mateus, Elsa
Landewé, Robert
author_role author
author2 van Dijk, Bastiaan
Ramiro, Sofia
van der Helm-van Mil, Annette
Combe, Bernard
van Schaardenburg, Dirkjan
de Wit, Maarten
Kent, Alison
Mateus, Elsa
Landewé, Robert
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Sepriano, Alexandre
van Dijk, Bastiaan
Ramiro, Sofia
van der Helm-van Mil, Annette
Combe, Bernard
van Schaardenburg, Dirkjan
de Wit, Maarten
Kent, Alison
Mateus, Elsa
Landewé, Robert
dc.subject.por.fl_str_mv Arthritis, Rheumatoid
Magnetic Resonance Imaging
Outcome and Process Assessment, Health Care
Rheumatology
Immunology and Allergy
Immunology
topic Arthritis, Rheumatoid
Magnetic Resonance Imaging
Outcome and Process Assessment, Health Care
Rheumatology
Immunology and Allergy
Immunology
description Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-28T22:37:18Z
2023-11-01
2023-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/160664
url http://hdl.handle.net/10362/160664
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2044-6055
PURE: 76186590
https://doi.org/10.1136/rmdopen-2023-003611
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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