Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/9129 |
Resumo: | Highlights: - Heat effect modification by air pollution on cardiovascular and respiratory mortality was investigated across 482 cities.- Heat effect was seen to be significantly modified by air pollutants PM10, PM2.5, O3, and NO2. -This study is the most extensive research to date investigating the heat effect modification on cardiovascular and respiratory mortality. - This is the first-ever study to deeply investigate effect modifications by air pollutants such as PM2.5 and NO2. |
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Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countriesHeatAir TemperatureAir PollutionCardiovascular MortalityRespiratory MortalityEffect modificationDeterminantes da Saúde e da DoençaAr e Saúde OcupacionalHighlights: - Heat effect modification by air pollution on cardiovascular and respiratory mortality was investigated across 482 cities.- Heat effect was seen to be significantly modified by air pollutants PM10, PM2.5, O3, and NO2. -This study is the most extensive research to date investigating the heat effect modification on cardiovascular and respiratory mortality. - This is the first-ever study to deeply investigate effect modifications by air pollutants such as PM2.5 and NO2.Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries. Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model. Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6-7.7), 11.3% (95%CI 11.2-11.3), and 14.3% (95% CI 14.1-14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5-1.6), 5.1 (95%CI 5.1-5.2), and 8.7 (95%CI 8.7-8.8) at low, medium, and high levels of O3, respectively. Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development.Masna Rai, Massimo Stafoggia, Francesca K. de’ Donato, Sofia Zafeiratou, Liliana Vazquez Fernandez, Siqi Zhang, Klea Katsouyanni, Evangelia Samoli, Shilpa Rao, Antonio Gasparrini, Pierre Masselot, and Alexandra Schneider were supported by the European Union’s Horizon 2020 Project Exhaustion (Grant ID: 820655). Joana Madureira was supported by the Fundação para a Ciência e a Tecnologia (FCT) (Grant SFRH/BPD/115112/2016).ElsevierRepositório Científico do Instituto Nacional de SaúdeRai, MasnaStafoggia, Massimode'Donato, FrancescaScortichini, MatteoZafeiratou, SofiaVazquez Fernandez, LilianaZhang, SiqiKatsouyanni, KleaSamoli, EvangeliaRao, ShilpaLavigne, EricGuo, YumingKan, HaidongOsorio, SamuelKyselý, JanUrban, AlešOrru, HansMaasikmets, MarekJaakkola, Jouni J.K.Ryti, NiiloPascal, MathildeHashizume, MasahiroFook Sheng Ng, ChrisAlahmad, BarrakHurtado Diaz, MagaliDe la Cruz Valencia, CésarNunes, BaltazarMadureira, JoanaScovronick, NoahGarland, Rebecca M.Kim, HoLee, WhanheeTobias, AurelioÍñiguez, CarmenForsberg, BertilÅström, ChristoferMaria Vicedo-Cabrera, AnaRagettli, Martina S.Leon Guo, Yue-LiangPan, Shih-ChunLi, ShanshanGasparrini, AntonioSera, FrancescoMasselot, PierreSchwartz, JoelZanobetti, AntonellaBell, Michelle L.Schneider, AlexandraBreitner, Susanne2024-02-20T13:41:52Z2023-02-132023-02-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/9129engEnviron Int. 2023 Apr:174:107825. doi: 10.1016/j.envint.2023.107825. Epub 2023 Feb 13.0160-412010.1016/j.envint.2023.107825info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-24T01:30:49Zoai:repositorio.insa.pt:10400.18/9129Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:11:15.065075Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries |
| title |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries |
| spellingShingle |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries Rai, Masna Heat Air Temperature Air Pollution Cardiovascular Mortality Respiratory Mortality Effect modification Determinantes da Saúde e da Doença Ar e Saúde Ocupacional |
| title_short |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries |
| title_full |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries |
| title_fullStr |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries |
| title_full_unstemmed |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries |
| title_sort |
Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries |
| author |
Rai, Masna |
| author_facet |
Rai, Masna Stafoggia, Massimo de'Donato, Francesca Scortichini, Matteo Zafeiratou, Sofia Vazquez Fernandez, Liliana Zhang, Siqi Katsouyanni, Klea Samoli, Evangelia Rao, Shilpa Lavigne, Eric Guo, Yuming Kan, Haidong Osorio, Samuel Kyselý, Jan Urban, Aleš Orru, Hans Maasikmets, Marek Jaakkola, Jouni J.K. Ryti, Niilo Pascal, Mathilde Hashizume, Masahiro Fook Sheng Ng, Chris Alahmad, Barrak Hurtado Diaz, Magali De la Cruz Valencia, César Nunes, Baltazar Madureira, Joana Scovronick, Noah Garland, Rebecca M. Kim, Ho Lee, Whanhee Tobias, Aurelio Íñiguez, Carmen Forsberg, Bertil Åström, Christofer Maria Vicedo-Cabrera, Ana Ragettli, Martina S. Leon Guo, Yue-Liang Pan, Shih-Chun Li, Shanshan Gasparrini, Antonio Sera, Francesco Masselot, Pierre Schwartz, Joel Zanobetti, Antonella Bell, Michelle L. Schneider, Alexandra Breitner, Susanne |
| author_role |
author |
| author2 |
Stafoggia, Massimo de'Donato, Francesca Scortichini, Matteo Zafeiratou, Sofia Vazquez Fernandez, Liliana Zhang, Siqi Katsouyanni, Klea Samoli, Evangelia Rao, Shilpa Lavigne, Eric Guo, Yuming Kan, Haidong Osorio, Samuel Kyselý, Jan Urban, Aleš Orru, Hans Maasikmets, Marek Jaakkola, Jouni J.K. Ryti, Niilo Pascal, Mathilde Hashizume, Masahiro Fook Sheng Ng, Chris Alahmad, Barrak Hurtado Diaz, Magali De la Cruz Valencia, César Nunes, Baltazar Madureira, Joana Scovronick, Noah Garland, Rebecca M. Kim, Ho Lee, Whanhee Tobias, Aurelio Íñiguez, Carmen Forsberg, Bertil Åström, Christofer Maria Vicedo-Cabrera, Ana Ragettli, Martina S. Leon Guo, Yue-Liang Pan, Shih-Chun Li, Shanshan Gasparrini, Antonio Sera, Francesco Masselot, Pierre Schwartz, Joel Zanobetti, Antonella Bell, Michelle L. Schneider, Alexandra Breitner, Susanne |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Rai, Masna Stafoggia, Massimo de'Donato, Francesca Scortichini, Matteo Zafeiratou, Sofia Vazquez Fernandez, Liliana Zhang, Siqi Katsouyanni, Klea Samoli, Evangelia Rao, Shilpa Lavigne, Eric Guo, Yuming Kan, Haidong Osorio, Samuel Kyselý, Jan Urban, Aleš Orru, Hans Maasikmets, Marek Jaakkola, Jouni J.K. Ryti, Niilo Pascal, Mathilde Hashizume, Masahiro Fook Sheng Ng, Chris Alahmad, Barrak Hurtado Diaz, Magali De la Cruz Valencia, César Nunes, Baltazar Madureira, Joana Scovronick, Noah Garland, Rebecca M. Kim, Ho Lee, Whanhee Tobias, Aurelio Íñiguez, Carmen Forsberg, Bertil Åström, Christofer Maria Vicedo-Cabrera, Ana Ragettli, Martina S. Leon Guo, Yue-Liang Pan, Shih-Chun Li, Shanshan Gasparrini, Antonio Sera, Francesco Masselot, Pierre Schwartz, Joel Zanobetti, Antonella Bell, Michelle L. Schneider, Alexandra Breitner, Susanne |
| dc.subject.por.fl_str_mv |
Heat Air Temperature Air Pollution Cardiovascular Mortality Respiratory Mortality Effect modification Determinantes da Saúde e da Doença Ar e Saúde Ocupacional |
| topic |
Heat Air Temperature Air Pollution Cardiovascular Mortality Respiratory Mortality Effect modification Determinantes da Saúde e da Doença Ar e Saúde Ocupacional |
| description |
Highlights: - Heat effect modification by air pollution on cardiovascular and respiratory mortality was investigated across 482 cities.- Heat effect was seen to be significantly modified by air pollutants PM10, PM2.5, O3, and NO2. -This study is the most extensive research to date investigating the heat effect modification on cardiovascular and respiratory mortality. - This is the first-ever study to deeply investigate effect modifications by air pollutants such as PM2.5 and NO2. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-02-13 2023-02-13T00:00:00Z 2024-02-20T13:41:52Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/9129 |
| url |
http://hdl.handle.net/10400.18/9129 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Environ Int. 2023 Apr:174:107825. doi: 10.1016/j.envint.2023.107825. Epub 2023 Feb 13. 0160-4120 10.1016/j.envint.2023.107825 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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