Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival

Detalhes bibliográficos
Autor(a) principal: Oliveira, Ana Isabel Ferreira
Data de Publicação: 2018
Outros Autores: Magalhães, Ana Xavier Silva, Barbosa, Catarina Moreira, Magalhães, Hugo, Henrique, Rui, Jerónimo, Carmen, Costa, Bruno Marques
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/57921
Resumo: Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors.
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spelling Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survivalHOTAIRPCars12826786rs920778SNPsScience & TechnologyAim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors.Fundação para a Ciência e Tecnologia (IF/00601/2012 to BM Costa; SFRH/BD/52287/2013 to AI Oliveira; SFRH/BD/88220/2012 to AX Magalhaes), Fundação Calouste Gulbenkian (BM Costa), Liga Portuguesa Contra o Cancro (BM Costa) and Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC; to AI Oliveira and AX Magalhaes). Project co-financed by Programa Operacional Regional do Norte (ON.2-O Novo Norte), Quadro de Referencia Estratégico Nacional (QREN), Fundo Europeu de Desenvolvimento Regional (FEDER) and a grant (74-CI-IPOP) from Research Center of Portuguese Oncology Institute of Porto (C Jeronimo).info:eu-repo/semantics/publishedVersionFuture MedicineUniversidade do MinhoOliveira, Ana Isabel FerreiraMagalhães, Ana Xavier SilvaBarbosa, Catarina MoreiraMagalhães, HugoHenrique, RuiJerónimo, CarmenCosta, Bruno Marques2018-032018-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57921eng1752-03631752-037110.2217/bmm-2017-025829436234info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:10:23Zoai:repositorium.sdum.uminho.pt:1822/57921Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:01:58.762307Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
title Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
spellingShingle Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
Oliveira, Ana Isabel Ferreira
HOTAIR
PCa
rs12826786
rs920778
SNPs
Science & Technology
title_short Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
title_full Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
title_fullStr Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
title_full_unstemmed Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
title_sort Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
author Oliveira, Ana Isabel Ferreira
author_facet Oliveira, Ana Isabel Ferreira
Magalhães, Ana Xavier Silva
Barbosa, Catarina Moreira
Magalhães, Hugo
Henrique, Rui
Jerónimo, Carmen
Costa, Bruno Marques
author_role author
author2 Magalhães, Ana Xavier Silva
Barbosa, Catarina Moreira
Magalhães, Hugo
Henrique, Rui
Jerónimo, Carmen
Costa, Bruno Marques
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Oliveira, Ana Isabel Ferreira
Magalhães, Ana Xavier Silva
Barbosa, Catarina Moreira
Magalhães, Hugo
Henrique, Rui
Jerónimo, Carmen
Costa, Bruno Marques
dc.subject.por.fl_str_mv HOTAIR
PCa
rs12826786
rs920778
SNPs
Science & Technology
topic HOTAIR
PCa
rs12826786
rs920778
SNPs
Science & Technology
description Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
2018-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/57921
url http://hdl.handle.net/1822/57921
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1752-0363
1752-0371
10.2217/bmm-2017-0258
29436234
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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