Differential effects of antiepileptic drugs on human bone cells

Detalhes bibliográficos
Autor(a) principal: Rocha, Sara
Data de Publicação: 2019
Outros Autores: Ferraz, Ricardo, Prudêncio, Cristina, Fernandes, Maria Helena, Costa-Rodrigues, Joao
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14181
Resumo: Antiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Shortly, valproic acid stimulated either osteoclastogenesis and osteoblastogenesis, whereas carbamazepine, gabapentin, and lamotrigine revealed an opposite behavior; topiramate elicited a decrease of osteoclast development and an increase in osteoblast differentiation. This is the first report describing the direct effects of different AED on human primary bone cells, which is a very important issue, because these drugs are usually consumed in long-term therapeutics, with acknowledged in vivo effects in bone tissue.
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spelling Differential effects of antiepileptic drugs on human bone cellsAntiepileptic drugsOsteoblastogenesisOsteoclastogenesisAntiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Shortly, valproic acid stimulated either osteoclastogenesis and osteoblastogenesis, whereas carbamazepine, gabapentin, and lamotrigine revealed an opposite behavior; topiramate elicited a decrease of osteoclast development and an increase in osteoblast differentiation. This is the first report describing the direct effects of different AED on human primary bone cells, which is a very important issue, because these drugs are usually consumed in long-term therapeutics, with acknowledged in vivo effects in bone tissue.WileyRepositório Científico do Instituto Politécnico do PortoRocha, SaraFerraz, RicardoPrudêncio, CristinaFernandes, Maria HelenaCosta-Rodrigues, Joao2020-05-02T00:30:30Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14181engRocha, S., Ferraz, R., Prudêncio, C., Fernandes, M. H., & Costa-Rodrigues, J. (2019). Differential effects of antiepileptic drugs on human bone cells. Journal of Cellular Physiology, 234(11), 19691–19701. https://doi.org/10.1002/jcp.2856910.1002/jcp.28569info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-10T01:49:05Zoai:recipp.ipp.pt:10400.22/14181Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:00.078861Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Differential effects of antiepileptic drugs on human bone cells
title Differential effects of antiepileptic drugs on human bone cells
spellingShingle Differential effects of antiepileptic drugs on human bone cells
Rocha, Sara
Antiepileptic drugs
Osteoblastogenesis
Osteoclastogenesis
title_short Differential effects of antiepileptic drugs on human bone cells
title_full Differential effects of antiepileptic drugs on human bone cells
title_fullStr Differential effects of antiepileptic drugs on human bone cells
title_full_unstemmed Differential effects of antiepileptic drugs on human bone cells
title_sort Differential effects of antiepileptic drugs on human bone cells
author Rocha, Sara
author_facet Rocha, Sara
Ferraz, Ricardo
Prudêncio, Cristina
Fernandes, Maria Helena
Costa-Rodrigues, Joao
author_role author
author2 Ferraz, Ricardo
Prudêncio, Cristina
Fernandes, Maria Helena
Costa-Rodrigues, Joao
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Rocha, Sara
Ferraz, Ricardo
Prudêncio, Cristina
Fernandes, Maria Helena
Costa-Rodrigues, Joao
dc.subject.por.fl_str_mv Antiepileptic drugs
Osteoblastogenesis
Osteoclastogenesis
topic Antiepileptic drugs
Osteoblastogenesis
Osteoclastogenesis
description Antiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Shortly, valproic acid stimulated either osteoclastogenesis and osteoblastogenesis, whereas carbamazepine, gabapentin, and lamotrigine revealed an opposite behavior; topiramate elicited a decrease of osteoclast development and an increase in osteoblast differentiation. This is the first report describing the direct effects of different AED on human primary bone cells, which is a very important issue, because these drugs are usually consumed in long-term therapeutics, with acknowledged in vivo effects in bone tissue.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-05-02T00:30:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14181
url http://hdl.handle.net/10400.22/14181
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rocha, S., Ferraz, R., Prudêncio, C., Fernandes, M. H., & Costa-Rodrigues, J. (2019). Differential effects of antiepileptic drugs on human bone cells. Journal of Cellular Physiology, 234(11), 19691–19701. https://doi.org/10.1002/jcp.28569
10.1002/jcp.28569
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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