Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021

• Autor(a) principal: Borges, Vítor
• Data de Publicação: 2021
• Outros Autores: Sousa, Carlos, Menezes, Luís, Gonçalves, António Maia, Picão, Miguel, Almeida, José Pedro, Vieita, Margarida, Santos, Rafael, Silva, Ana Rita, Costa, Mariana, Carneiro, Luís, Casaca, Pedro, Pinto-Leite, Pedro, Peralta-Santos, André, Isidro, Joana, Duarte, Sílvia, Vieira, Luís, Guiomar, Raquel, Silva, Susana, Nunes, Baltazar, Gomes, João P.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.18/8056
• topic: B.1.1.7 Lineage; RT-PCR; SARS-CoV-2; Genome Sequencing; Laboratory Surveillance; Spike Gene Target Failure (SGTF); Spike Gene Target Late Detection (SGTL); Infecções Respiratórias; Estados de Saúde e de Doença; Portugal

We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.