Development of a chlorhexidine delivery system based on dental reline acrylic resins
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/59191 |
Resumo: | The high recurrence rate of common denture stomatitis after antifungal treatment is still concerning. This condition is caused by low patient compliance and incomplete local elimination of the main etiological factor — Candida albicans, often associated with other microorganisms, such as Streptococcus species. Impregnating denture materials with antimicrobials for local delivery is a strategy that can overcome the side effects and improve the efficacy of conventional treatments (topical and/or systemic). In this work, we describe the development of three hard autopolymerizing reline acrylic resins (Kooliner, Ufi Gel Hard, and Probase Cold) loaded with different percentages of chlorhexidine (CHX). The novel formulations were characterized based on their antimicrobial activity, mechanical, morphological and surface properties, in-vitro drug release profiles, and cytotoxicity. The addition of CHX in all resins did not change their chemical and mechanical structure. Among all the tested formulations, Probase Cold loaded with 5 wt% CHX showed the most promising results in terms of antimicrobial activity and lack of serious detrimental mechanical, morphological, surface, and biological properties. |
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Development of a chlorhexidine delivery system based on dental reline acrylic resinsAntimicrobialPolymeric resinsDrug delivery systemsDenture stomatitisThe high recurrence rate of common denture stomatitis after antifungal treatment is still concerning. This condition is caused by low patient compliance and incomplete local elimination of the main etiological factor — Candida albicans, often associated with other microorganisms, such as Streptococcus species. Impregnating denture materials with antimicrobials for local delivery is a strategy that can overcome the side effects and improve the efficacy of conventional treatments (topical and/or systemic). In this work, we describe the development of three hard autopolymerizing reline acrylic resins (Kooliner, Ufi Gel Hard, and Probase Cold) loaded with different percentages of chlorhexidine (CHX). The novel formulations were characterized based on their antimicrobial activity, mechanical, morphological and surface properties, in-vitro drug release profiles, and cytotoxicity. The addition of CHX in all resins did not change their chemical and mechanical structure. Among all the tested formulations, Probase Cold loaded with 5 wt% CHX showed the most promising results in terms of antimicrobial activity and lack of serious detrimental mechanical, morphological, surface, and biological properties.The authors thank the Fundação para a Ciência e Tecnologia (FCT), Portugal for the financial support and Centro 2020 through the following projects: UIDB/04138/2020 and UIDP/04138/2020 (iMed.ULisboa), UIDB/05608/2020 and UIDP/05608/2020 (H&TRC), UIDP/04044/2020, PAMI - ROTEIRO/0328/2013 (N° 022158) and MATIS (CENTRO-01-0145-FEDER-000014 - 3362), L. Gonçalves Principal Researcher grant (CEECIND/03143/2017). Finally, the authors would like to thank VOCO GmbH (Cuxhaven, Germany) for the donation of the Ufi Gel Hard and Prof Alice Nogueira Alves for graphical advice.ElsevierRepositório da Universidade de LisboaBettencourt, AnaCosta, JoanaRibeiro, Isabel A. C.Gonçalves, LídiaArias-Moliz, Maria TeresaDias, Juliana R.Franco, MargaridaAlves, Nuno M.Portugal, JaimeNeves, Cristina B.2023-09-08T17:21:18Z2023-012023-02-27T14:15:17Z2023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59191engBettencourt AF, Costa J, Ribeiro IAC, Gonçalves L, Arias-Moliz MT, Dias JR, et al. Development of a chlorhexidine delivery system based on dental reline acrylic resins. International Journal of Pharmaceutics [Internet]. 25 de janeiro de 2023;631:122470. Disponível em: https://www.sciencedirect.com/science/article/pii/S03785173220102500378-5173cv-prod-314757310.1016/j.ijpharm.2022.122470info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:03Zoai:repositorio.ul.pt:10451/59191Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:59.212083Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of a chlorhexidine delivery system based on dental reline acrylic resins |
title |
Development of a chlorhexidine delivery system based on dental reline acrylic resins |
spellingShingle |
Development of a chlorhexidine delivery system based on dental reline acrylic resins Bettencourt, Ana Antimicrobial Polymeric resins Drug delivery systems Denture stomatitis |
title_short |
Development of a chlorhexidine delivery system based on dental reline acrylic resins |
title_full |
Development of a chlorhexidine delivery system based on dental reline acrylic resins |
title_fullStr |
Development of a chlorhexidine delivery system based on dental reline acrylic resins |
title_full_unstemmed |
Development of a chlorhexidine delivery system based on dental reline acrylic resins |
title_sort |
Development of a chlorhexidine delivery system based on dental reline acrylic resins |
author |
Bettencourt, Ana |
author_facet |
Bettencourt, Ana Costa, Joana Ribeiro, Isabel A. C. Gonçalves, Lídia Arias-Moliz, Maria Teresa Dias, Juliana R. Franco, Margarida Alves, Nuno M. Portugal, Jaime Neves, Cristina B. |
author_role |
author |
author2 |
Costa, Joana Ribeiro, Isabel A. C. Gonçalves, Lídia Arias-Moliz, Maria Teresa Dias, Juliana R. Franco, Margarida Alves, Nuno M. Portugal, Jaime Neves, Cristina B. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Bettencourt, Ana Costa, Joana Ribeiro, Isabel A. C. Gonçalves, Lídia Arias-Moliz, Maria Teresa Dias, Juliana R. Franco, Margarida Alves, Nuno M. Portugal, Jaime Neves, Cristina B. |
dc.subject.por.fl_str_mv |
Antimicrobial Polymeric resins Drug delivery systems Denture stomatitis |
topic |
Antimicrobial Polymeric resins Drug delivery systems Denture stomatitis |
description |
The high recurrence rate of common denture stomatitis after antifungal treatment is still concerning. This condition is caused by low patient compliance and incomplete local elimination of the main etiological factor — Candida albicans, often associated with other microorganisms, such as Streptococcus species. Impregnating denture materials with antimicrobials for local delivery is a strategy that can overcome the side effects and improve the efficacy of conventional treatments (topical and/or systemic). In this work, we describe the development of three hard autopolymerizing reline acrylic resins (Kooliner, Ufi Gel Hard, and Probase Cold) loaded with different percentages of chlorhexidine (CHX). The novel formulations were characterized based on their antimicrobial activity, mechanical, morphological and surface properties, in-vitro drug release profiles, and cytotoxicity. The addition of CHX in all resins did not change their chemical and mechanical structure. Among all the tested formulations, Probase Cold loaded with 5 wt% CHX showed the most promising results in terms of antimicrobial activity and lack of serious detrimental mechanical, morphological, surface, and biological properties. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-08T17:21:18Z 2023-01 2023-02-27T14:15:17Z 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/59191 |
url |
http://hdl.handle.net/10451/59191 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bettencourt AF, Costa J, Ribeiro IAC, Gonçalves L, Arias-Moliz MT, Dias JR, et al. Development of a chlorhexidine delivery system based on dental reline acrylic resins. International Journal of Pharmaceutics [Internet]. 25 de janeiro de 2023;631:122470. Disponível em: https://www.sciencedirect.com/science/article/pii/S0378517322010250 0378-5173 cv-prod-3147573 10.1016/j.ijpharm.2022.122470 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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