Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker

Detalhes bibliográficos
Autor(a) principal: Santos, J.
Data de Publicação: 2015
Outros Autores: Martins, L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/1982
Resumo: Kidney transplantation is the treatment of choice for end-stage renal disease. The evaluation of graft function is mandatory in the management of renal transplant recipients. Glomerular filtration rate (GFR), is generally considered the best index of graft function and also a predictor of graft and patient survival. However GFR measurement using inulin clearance, the gold standard for its measurement and exogenous markers such as radiolabeled isotopes ((51)Cr EDTA, (99m)Tc DTPA or (125)I Iothalamate) and non-radioactive contrast agents (Iothalamate or Iohexol), is laborious as well as expensive, being rarely used in clinical practice. Therefore, endogenous markers, such as serum creatinine or cystatin C, are used to estimate kidney function, and equations using these markers adjusted to other variables, mainly demographic, are an attempt to improve accuracy in estimation of GFR (eGFR). Nevertheless, there is some concern about the inability of the available eGFR equations to accurately identify changes in GFR, in kidney transplant recipients. This article will review and discuss the performance and limitations of these endogenous markers and their equations as estimators of GFR in the kidney transplant recipients, and their ability in predicting significant clinical outcomes.
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spelling Estimating glomerular filtration rate in kidney transplantation: Still searching for the best markerGlomerular filtration rate estimationCreatinineCystatin CKidney transplantationClinical outcomesKidney transplantation is the treatment of choice for end-stage renal disease. The evaluation of graft function is mandatory in the management of renal transplant recipients. Glomerular filtration rate (GFR), is generally considered the best index of graft function and also a predictor of graft and patient survival. However GFR measurement using inulin clearance, the gold standard for its measurement and exogenous markers such as radiolabeled isotopes ((51)Cr EDTA, (99m)Tc DTPA or (125)I Iothalamate) and non-radioactive contrast agents (Iothalamate or Iohexol), is laborious as well as expensive, being rarely used in clinical practice. Therefore, endogenous markers, such as serum creatinine or cystatin C, are used to estimate kidney function, and equations using these markers adjusted to other variables, mainly demographic, are an attempt to improve accuracy in estimation of GFR (eGFR). Nevertheless, there is some concern about the inability of the available eGFR equations to accurately identify changes in GFR, in kidney transplant recipients. This article will review and discuss the performance and limitations of these endogenous markers and their equations as estimators of GFR in the kidney transplant recipients, and their ability in predicting significant clinical outcomes.Baishideng Pub.Repositório Científico do Centro Hospitalar Universitário de Santo AntónioSantos, J.Martins, L.2016-08-01T08:57:53Z2015-07-062015-07-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/1982engWorld J Nephrol. 2015 Jul 6;4(3):345-53.2220-612410.5527/wjn.v4.i3.345info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:58:32Zoai:repositorio.chporto.pt:10400.16/1982Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:17.233444Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
title Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
spellingShingle Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
Santos, J.
Glomerular filtration rate estimation
Creatinine
Cystatin C
Kidney transplantation
Clinical outcomes
title_short Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
title_full Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
title_fullStr Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
title_full_unstemmed Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
title_sort Estimating glomerular filtration rate in kidney transplantation: Still searching for the best marker
author Santos, J.
author_facet Santos, J.
Martins, L.
author_role author
author2 Martins, L.
author2_role author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Santos, J.
Martins, L.
dc.subject.por.fl_str_mv Glomerular filtration rate estimation
Creatinine
Cystatin C
Kidney transplantation
Clinical outcomes
topic Glomerular filtration rate estimation
Creatinine
Cystatin C
Kidney transplantation
Clinical outcomes
description Kidney transplantation is the treatment of choice for end-stage renal disease. The evaluation of graft function is mandatory in the management of renal transplant recipients. Glomerular filtration rate (GFR), is generally considered the best index of graft function and also a predictor of graft and patient survival. However GFR measurement using inulin clearance, the gold standard for its measurement and exogenous markers such as radiolabeled isotopes ((51)Cr EDTA, (99m)Tc DTPA or (125)I Iothalamate) and non-radioactive contrast agents (Iothalamate or Iohexol), is laborious as well as expensive, being rarely used in clinical practice. Therefore, endogenous markers, such as serum creatinine or cystatin C, are used to estimate kidney function, and equations using these markers adjusted to other variables, mainly demographic, are an attempt to improve accuracy in estimation of GFR (eGFR). Nevertheless, there is some concern about the inability of the available eGFR equations to accurately identify changes in GFR, in kidney transplant recipients. This article will review and discuss the performance and limitations of these endogenous markers and their equations as estimators of GFR in the kidney transplant recipients, and their ability in predicting significant clinical outcomes.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-06
2015-07-06T00:00:00Z
2016-08-01T08:57:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/1982
url http://hdl.handle.net/10400.16/1982
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv World J Nephrol. 2015 Jul 6;4(3):345-53.
2220-6124
10.5527/wjn.v4.i3.345
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Baishideng Pub.
publisher.none.fl_str_mv Baishideng Pub.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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