Engineered extracellular vesicles as brain therapeutics

Detalhes bibliográficos
Autor(a) principal: Lino, Miguel M.
Data de Publicação: 2021
Outros Autores: Simões, Susana, Tomatis, Francesca, Albino, Inês, Barrera, Angela, Vivien, Denis, Sobrino, Tomás, Ferreira, Lino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/102069
https://doi.org/10.1016/j.jconrel.2021.08.037
Resumo: Extracellular vesicles (EVs) are communication channels between different cell types in the brain, between the brain and the periphery and vice-versa, playing a fundamental role in physiology and pathology. The evidence that EVs might be able to cross the blood-brain barrier (BBB) make them very promising candidates as nanocarriers to treat brain pathologies. EVs contain a cocktail of bioactive factors, yet their content and surface can be further engineered to enhance their biological activity, stability and targeting ability. Native and engineered EVs have been reported for the treatment of different brain pathologies, although issues related to their modest accumulation and limited local therapeutic effect in the brain still need to be addressed. In this review, we cover the therapeutic applications of native and bioengineered EVs for brain diseases. We also review recent data about the interaction between EVs and the BBB and discuss the challenges and opportunities in clinical translation of EVs as brain therapeutics.
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spelling Engineered extracellular vesicles as brain therapeuticsExtracellular vesicles (EVs) are communication channels between different cell types in the brain, between the brain and the periphery and vice-versa, playing a fundamental role in physiology and pathology. The evidence that EVs might be able to cross the blood-brain barrier (BBB) make them very promising candidates as nanocarriers to treat brain pathologies. EVs contain a cocktail of bioactive factors, yet their content and surface can be further engineered to enhance their biological activity, stability and targeting ability. Native and engineered EVs have been reported for the treatment of different brain pathologies, although issues related to their modest accumulation and limited local therapeutic effect in the brain still need to be addressed. In this review, we cover the therapeutic applications of native and bioengineered EVs for brain diseases. We also review recent data about the interaction between EVs and the BBB and discuss the challenges and opportunities in clinical translation of EVs as brain therapeutics.This work was partially supported by the Portuguese ‘Fundação para a Ciência e a Tecnologia’ (FCT) through the project exo-Heart POCI-01-0145-FEDER-029919, co-funded by COMPETE2020- UE and CENTRO-01-0145-FEDER-000014 through ‘Programa Operacional Regional do Centro’ CENTRO2020; Project “NeuroAtlantic”, Ref: EAPA_791/2018, which is co-funded by Program Interreg Atlantic Space through European fund for Regional Development. Project 0624_2IQBIONEURO_6_E, funded by the European Regional Development Fund (ERDF) through an INTERREG V A España Portugal (POCTEP) 2014-2020. Project LABEL- Radio-labeling of extracellular vesicles for applications in diagnostic and therapeutics” funded by FEDER through Portugal2020 program. European Union’s Horizon 2020 research and innovation program under grant agreement number 764958 (project NANOSTEM) and grant agreement number 669088 (project ERAatUC). Furthermore, this study was also supported by grants from the Xunta de Galicia (Consellería de Economía e Industria: IN607D2020/09), Science Ministry of Spain (RTI2018-102165-B-I00), and Dr. Sobrino (CPII17/00027), is recipient of a research contract from the Miguel Servet Program (Instituto de Salud Carlos III).Elsevier2021-10-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/102069http://hdl.handle.net/10316/102069https://doi.org/10.1016/j.jconrel.2021.08.037enghttps://www.sciencedirect.com/science/article/pii/S0168365921004430Lino, Miguel M.Simões, SusanaTomatis, FrancescaAlbino, InêsBarrera, AngelaVivien, DenisSobrino, TomásFerreira, Linoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:19:51Zoai:estudogeral.uc.pt:10316/102069Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:19:06.610063Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Engineered extracellular vesicles as brain therapeutics
title Engineered extracellular vesicles as brain therapeutics
spellingShingle Engineered extracellular vesicles as brain therapeutics
Lino, Miguel M.
title_short Engineered extracellular vesicles as brain therapeutics
title_full Engineered extracellular vesicles as brain therapeutics
title_fullStr Engineered extracellular vesicles as brain therapeutics
title_full_unstemmed Engineered extracellular vesicles as brain therapeutics
title_sort Engineered extracellular vesicles as brain therapeutics
author Lino, Miguel M.
author_facet Lino, Miguel M.
Simões, Susana
Tomatis, Francesca
Albino, Inês
Barrera, Angela
Vivien, Denis
Sobrino, Tomás
Ferreira, Lino
author_role author
author2 Simões, Susana
Tomatis, Francesca
Albino, Inês
Barrera, Angela
Vivien, Denis
Sobrino, Tomás
Ferreira, Lino
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lino, Miguel M.
Simões, Susana
Tomatis, Francesca
Albino, Inês
Barrera, Angela
Vivien, Denis
Sobrino, Tomás
Ferreira, Lino
description Extracellular vesicles (EVs) are communication channels between different cell types in the brain, between the brain and the periphery and vice-versa, playing a fundamental role in physiology and pathology. The evidence that EVs might be able to cross the blood-brain barrier (BBB) make them very promising candidates as nanocarriers to treat brain pathologies. EVs contain a cocktail of bioactive factors, yet their content and surface can be further engineered to enhance their biological activity, stability and targeting ability. Native and engineered EVs have been reported for the treatment of different brain pathologies, although issues related to their modest accumulation and limited local therapeutic effect in the brain still need to be addressed. In this review, we cover the therapeutic applications of native and bioengineered EVs for brain diseases. We also review recent data about the interaction between EVs and the BBB and discuss the challenges and opportunities in clinical translation of EVs as brain therapeutics.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/102069
http://hdl.handle.net/10316/102069
https://doi.org/10.1016/j.jconrel.2021.08.037
url http://hdl.handle.net/10316/102069
https://doi.org/10.1016/j.jconrel.2021.08.037
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0168365921004430
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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