Adhesive bioactive coatings inspired by sea life

Detalhes bibliográficos
Autor(a) principal: Rego, Sónia J.
Data de Publicação: 2016
Outros Autores: Vale, A. C., Luz, Gisela Andreia Monteiro, Mano, J. F., Alves, N. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/40916
Resumo: Inspired by nature, in particular by the marine mussels adhesive proteins (MAPs) and by the tough brick-and-mortar nacre-like structure, novel multilayered films are prepared in the present work. Organic-inorganic multilayered films, with an architecture similar to nacre based on bioactive glass nanoparticles (BG), chitosan and hyaluronic acid modified with catechol groups, which are the main responsible for the outstanding adhesion in MAPs, are developed for the first time. The biomimetic conjugate is prepared by carbodiimide chemistry and analyzed by ultraviolet-visible spectrophotometry. The build-up of the multilayered films is monitored with a quartz crystal microbalance with dissipation monitoring and their topography is characterized by atomic force microscopy. The mechanical properties reveal that the films containing catechol groups and BG present an enhanced adhesion. Moreover, the bioactivity of the films upon immersion in a simulated body fluid solution for 7 days is evaluated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction. It was found that the constructed films promote the formation of bone-like apatite in vitro. Such multifunctional mussel inspired LbL films, which combine enhanced adhesion and bioactivity, could be potentially used as coatings of a variety of implants for orthopedic applications.
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spelling Adhesive bioactive coatings inspired by sea lifeDopamineLbL multilayer assembliesScience & TechnologyInspired by nature, in particular by the marine mussels adhesive proteins (MAPs) and by the tough brick-and-mortar nacre-like structure, novel multilayered films are prepared in the present work. Organic-inorganic multilayered films, with an architecture similar to nacre based on bioactive glass nanoparticles (BG), chitosan and hyaluronic acid modified with catechol groups, which are the main responsible for the outstanding adhesion in MAPs, are developed for the first time. The biomimetic conjugate is prepared by carbodiimide chemistry and analyzed by ultraviolet-visible spectrophotometry. The build-up of the multilayered films is monitored with a quartz crystal microbalance with dissipation monitoring and their topography is characterized by atomic force microscopy. The mechanical properties reveal that the films containing catechol groups and BG present an enhanced adhesion. Moreover, the bioactivity of the films upon immersion in a simulated body fluid solution for 7 days is evaluated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction. It was found that the constructed films promote the formation of bone-like apatite in vitro. Such multifunctional mussel inspired LbL films, which combine enhanced adhesion and bioactivity, could be potentially used as coatings of a variety of implants for orthopedic applications.The authors want to acknowledge the Portuguese Foundation for Science and Technology (FCT) and the European program FEDER/COMPETE for the financial support through project BioSeaGlue: EXPL/CTM-BIO/0646/2013 (FCOMP-01-0124- FEDER-041105).ACS PublicationsUniversidade do MinhoRego, Sónia J.Vale, A. C.Luz, Gisela Andreia MonteiroMano, J. F.Alves, N. M.2016-012016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/40916engRego S. J., Vale A. C., Luz G. M., Mano J. F., Alves N. M. Adhesive Bioactive Coatings Inspired by Sea Life, Langmuir, doi:10.1021/acs.langmuir.5b03508, 20160743-746310.1021/acs.langmuir.5b0350826653103info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:43:11Zoai:repositorium.sdum.uminho.pt:1822/40916Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:40:35.881826Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Adhesive bioactive coatings inspired by sea life
title Adhesive bioactive coatings inspired by sea life
spellingShingle Adhesive bioactive coatings inspired by sea life
Rego, Sónia J.
Dopamine
LbL multilayer assemblies
Science & Technology
title_short Adhesive bioactive coatings inspired by sea life
title_full Adhesive bioactive coatings inspired by sea life
title_fullStr Adhesive bioactive coatings inspired by sea life
title_full_unstemmed Adhesive bioactive coatings inspired by sea life
title_sort Adhesive bioactive coatings inspired by sea life
author Rego, Sónia J.
author_facet Rego, Sónia J.
Vale, A. C.
Luz, Gisela Andreia Monteiro
Mano, J. F.
Alves, N. M.
author_role author
author2 Vale, A. C.
Luz, Gisela Andreia Monteiro
Mano, J. F.
Alves, N. M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rego, Sónia J.
Vale, A. C.
Luz, Gisela Andreia Monteiro
Mano, J. F.
Alves, N. M.
dc.subject.por.fl_str_mv Dopamine
LbL multilayer assemblies
Science & Technology
topic Dopamine
LbL multilayer assemblies
Science & Technology
description Inspired by nature, in particular by the marine mussels adhesive proteins (MAPs) and by the tough brick-and-mortar nacre-like structure, novel multilayered films are prepared in the present work. Organic-inorganic multilayered films, with an architecture similar to nacre based on bioactive glass nanoparticles (BG), chitosan and hyaluronic acid modified with catechol groups, which are the main responsible for the outstanding adhesion in MAPs, are developed for the first time. The biomimetic conjugate is prepared by carbodiimide chemistry and analyzed by ultraviolet-visible spectrophotometry. The build-up of the multilayered films is monitored with a quartz crystal microbalance with dissipation monitoring and their topography is characterized by atomic force microscopy. The mechanical properties reveal that the films containing catechol groups and BG present an enhanced adhesion. Moreover, the bioactivity of the films upon immersion in a simulated body fluid solution for 7 days is evaluated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction. It was found that the constructed films promote the formation of bone-like apatite in vitro. Such multifunctional mussel inspired LbL films, which combine enhanced adhesion and bioactivity, could be potentially used as coatings of a variety of implants for orthopedic applications.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/40916
url https://hdl.handle.net/1822/40916
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rego S. J., Vale A. C., Luz G. M., Mano J. F., Alves N. M. Adhesive Bioactive Coatings Inspired by Sea Life, Langmuir, doi:10.1021/acs.langmuir.5b03508, 2016
0743-7463
10.1021/acs.langmuir.5b03508
26653103
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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