Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/10581 |
Resumo: | Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). Sample from Serbia expressed slightly higher antimutagenic properties with inhibition rate of 58.7%. Sample from Portugal gave inhibition rate of 51.7%. Protocatechuic acid had inhibition rate I of his+ revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound – protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score. |
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Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acidAllium cepa assayAntimitoticAntimutagenicAmes testMorchella esculentaProtocatechuic acidMorchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). Sample from Serbia expressed slightly higher antimutagenic properties with inhibition rate of 58.7%. Sample from Portugal gave inhibition rate of 51.7%. Protocatechuic acid had inhibition rate I of his+ revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound – protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.Serbian Ministry of Education, Science and Technological Development; FCT Portugal; COMPETE/QREN/EU, PTDC/AGR-ALI/110062/2009 PEst-OE/AGR/UI0690/2011Taylor&Francis LtdBiblioteca Digital do IPBStojković, DejanDavidović, SlobodanŽivković, JelenaGlamočlija, JasminaĆirić, AnaFerreira, Isabel C.F.R.Soković, Marina2014-09-24T16:50:48Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/10581engStojković, Dejan; Davidović, Slobodan; Živković, Jelena; Glamočlija, Jasmina; Ćirić, Ana; Ferreira, Isabel C.F.R.; Soković, Marina (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. Frontiers in Life Science. ISSN 2155-3769. 7:3-4, p. 218-2232155-376910.1080/21553769.2014.901925info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:25:13Zoai:bibliotecadigital.ipb.pt:10198/10581Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:01:25.298676Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid |
title |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid |
spellingShingle |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid Stojković, Dejan Allium cepa assay Antimitotic Antimutagenic Ames test Morchella esculenta Protocatechuic acid |
title_short |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid |
title_full |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid |
title_fullStr |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid |
title_full_unstemmed |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid |
title_sort |
Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid |
author |
Stojković, Dejan |
author_facet |
Stojković, Dejan Davidović, Slobodan Živković, Jelena Glamočlija, Jasmina Ćirić, Ana Ferreira, Isabel C.F.R. Soković, Marina |
author_role |
author |
author2 |
Davidović, Slobodan Živković, Jelena Glamočlija, Jasmina Ćirić, Ana Ferreira, Isabel C.F.R. Soković, Marina |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Stojković, Dejan Davidović, Slobodan Živković, Jelena Glamočlija, Jasmina Ćirić, Ana Ferreira, Isabel C.F.R. Soković, Marina |
dc.subject.por.fl_str_mv |
Allium cepa assay Antimitotic Antimutagenic Ames test Morchella esculenta Protocatechuic acid |
topic |
Allium cepa assay Antimitotic Antimutagenic Ames test Morchella esculenta Protocatechuic acid |
description |
Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). Sample from Serbia expressed slightly higher antimutagenic properties with inhibition rate of 58.7%. Sample from Portugal gave inhibition rate of 51.7%. Protocatechuic acid had inhibition rate I of his+ revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound – protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z 2014-09-24T16:50:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/10581 |
url |
http://hdl.handle.net/10198/10581 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Stojković, Dejan; Davidović, Slobodan; Živković, Jelena; Glamočlija, Jasmina; Ćirić, Ana; Ferreira, Isabel C.F.R.; Soković, Marina (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. Frontiers in Life Science. ISSN 2155-3769. 7:3-4, p. 218-223 2155-3769 10.1080/21553769.2014.901925 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor&Francis Ltd |
publisher.none.fl_str_mv |
Taylor&Francis Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135246599323648 |