Bioactivity of phenolic acids: Metabolites versus parent compounds: A review

Detalhes bibliográficos
Autor(a) principal: Heleno, Sandrina A.
Data de Publicação: 2015
Outros Autores: Martins, Anabela, Queiroz, Maria João R. P., Ferreira, Isabel C. F. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/39808
Resumo: Phenolic acids are present in our diet in different foods. In particular, mushrooms are a good source of these molecules. Due to their bioactive properties, phenolic acids are extensively studied and there is evidence of their role in disease prevention. Nevertheless, in vivo, these compounds are metabolized and circulate in the organism as glucuronated, sulfated and methylated metabolites, displaying higher or lower bioactivity. To clarify the importance of the metabolism of phenolic acids, the knowledge about the bioactivity of the metabolites is extremely important. In this review, chemical features, biosynthesis and bioavailability of phenolic acids are discussed as well as the chemical and enzymatic synthesis of their metabolites. Finally, the metabolites bioactive properties are compared with that of the corresponding parental compounds.
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spelling Bioactivity of phenolic acids: Metabolites versus parent compounds: A reviewMushroomsPhenolic acidsBiosynthesis/bioavailabilityMetabolitesChemical/enzymatic synthesis;BioactivityCiências Naturais::Ciências QuímicasScience & TechnologyPhenolic acids are present in our diet in different foods. In particular, mushrooms are a good source of these molecules. Due to their bioactive properties, phenolic acids are extensively studied and there is evidence of their role in disease prevention. Nevertheless, in vivo, these compounds are metabolized and circulate in the organism as glucuronated, sulfated and methylated metabolites, displaying higher or lower bioactivity. To clarify the importance of the metabolism of phenolic acids, the knowledge about the bioactivity of the metabolites is extremely important. In this review, chemical features, biosynthesis and bioavailability of phenolic acids are discussed as well as the chemical and enzymatic synthesis of their metabolites. Finally, the metabolites bioactive properties are compared with that of the corresponding parental compounds.The authors are grateful to Fundação para a Ciência e a Tecnologia (FCT, Portugal) and FEDER-COMPETE/QREN/EU for the financial support through the research centres (PEst-C/QUI/UI0686/2011 and PEst-OE/AGR/UI0690/2011). S.A. Heleno (BD/70304/2010) also thanks FCT, POPH-QREN and FSE for her grant.ElsevierUniversidade do MinhoHeleno, Sandrina A.Martins, AnabelaQueiroz, Maria João R. P.Ferreira, Isabel C. F. R.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/39808engHeleno, S. A., Martins, A., Queiroz, M. J. R. P., & Ferreira, I. C. F. R. (2015). Bioactivity of phenolic acids: Metabolites versus parent compounds: A review. Food Chemistry, 173, 501-513. doi: 10.1016/j.foodchem.2014.10.0570308-814610.1016/j.foodchem.2014.10.05725466052http://dx.doi.org/10.1016/j.foodchem.2014.10.057info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:41ZPortal AgregadorONG
dc.title.none.fl_str_mv Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
title Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
spellingShingle Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
Heleno, Sandrina A.
Mushrooms
Phenolic acids
Biosynthesis/bioavailability
Metabolites
Chemical/enzymatic synthesis;
Bioactivity
Ciências Naturais::Ciências Químicas
Science & Technology
title_short Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
title_full Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
title_fullStr Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
title_full_unstemmed Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
title_sort Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
author Heleno, Sandrina A.
author_facet Heleno, Sandrina A.
Martins, Anabela
Queiroz, Maria João R. P.
Ferreira, Isabel C. F. R.
author_role author
author2 Martins, Anabela
Queiroz, Maria João R. P.
Ferreira, Isabel C. F. R.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Heleno, Sandrina A.
Martins, Anabela
Queiroz, Maria João R. P.
Ferreira, Isabel C. F. R.
dc.subject.por.fl_str_mv Mushrooms
Phenolic acids
Biosynthesis/bioavailability
Metabolites
Chemical/enzymatic synthesis;
Bioactivity
Ciências Naturais::Ciências Químicas
Science & Technology
topic Mushrooms
Phenolic acids
Biosynthesis/bioavailability
Metabolites
Chemical/enzymatic synthesis;
Bioactivity
Ciências Naturais::Ciências Químicas
Science & Technology
description Phenolic acids are present in our diet in different foods. In particular, mushrooms are a good source of these molecules. Due to their bioactive properties, phenolic acids are extensively studied and there is evidence of their role in disease prevention. Nevertheless, in vivo, these compounds are metabolized and circulate in the organism as glucuronated, sulfated and methylated metabolites, displaying higher or lower bioactivity. To clarify the importance of the metabolism of phenolic acids, the knowledge about the bioactivity of the metabolites is extremely important. In this review, chemical features, biosynthesis and bioavailability of phenolic acids are discussed as well as the chemical and enzymatic synthesis of their metabolites. Finally, the metabolites bioactive properties are compared with that of the corresponding parental compounds.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/39808
url http://hdl.handle.net/1822/39808
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Heleno, S. A., Martins, A., Queiroz, M. J. R. P., & Ferreira, I. C. F. R. (2015). Bioactivity of phenolic acids: Metabolites versus parent compounds: A review. Food Chemistry, 173, 501-513. doi: 10.1016/j.foodchem.2014.10.057
0308-8146
10.1016/j.foodchem.2014.10.057
25466052
http://dx.doi.org/10.1016/j.foodchem.2014.10.057
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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