Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/34378 |
Resumo: | © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic reviewHeart failureSinus rhythmPlatelet aggregation inhibitorsAnticoagulants© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.AIM: To assess the efficacy and safety of antithrombotic drugs (antiplatelet or anticoagulant drugs) compared to no antithrombotic treatment or placebo in patients with heart failure (HF) and sinus rhythm. METHODS: We searched Medline and Cochrane Library for randomized controlled trials evaluating antithrombotic treatment and no antithrombotic treatment in patients with HF and sinus rhythm. Risk ratio (RR) and 95%CIs were estimated performing meta-analysis with random effects method. RESULTS: Two studies met the inclusion criteria: Heart failure Long-term Antithrombotic Study and Warfarin/Aspirin Study in Heart failure, with 336 patients and mean follow-up 1.8-2.25 years. Stroke risk was not reduced by acetylsalicylic acid (RR = 1.18, 95%CI: 0.17-8.15), oral anticoagulation (RR = 0.30, 95%CI: 0.03-2.65) or overall antithrombotic drugs (RR = 0.52, 95%CI: 0.10-2.74). Acetylsalicylic acid showed a significant increased risk of worsening HF (RR = 1.78, 95%CI: 1.08-2.92), while oral anticoagulation had no impact in this outcome (RR = 1.03, 95%CI: 0.61-1.75). Overall antithrombotic drugs showed a significant risk increase of major bleeding (RR = 6.99, 95%CI: 0.89-54.64). CONCLUSION: Best available evidence does not support the routine use of antithrombotic drugs in patients with HF and sinus rhythm. These drugs, particularly oral anticoagulation has the hazard of increase significantly major bleeding risk.Baishideng Publishing GroupRepositório da Universidade de LisboaCaldeira, DanielCruz, InêsCalé, RitaMartins, CristinaPereira, HélderFerreira, Joaquim JPinto, Fausto J.Costa, João2018-07-27T14:24:23Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/34378engWorld J Meta-Anal 2015 February 26; 3(1): 36-422308-384010.13105/wjma.v3.i1.36info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:29:39Zoai:repositorio.ul.pt:10451/34378Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:49:05.890752Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review |
title |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review |
spellingShingle |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review Caldeira, Daniel Heart failure Sinus rhythm Platelet aggregation inhibitors Anticoagulants |
title_short |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review |
title_full |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review |
title_fullStr |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review |
title_full_unstemmed |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review |
title_sort |
Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review |
author |
Caldeira, Daniel |
author_facet |
Caldeira, Daniel Cruz, Inês Calé, Rita Martins, Cristina Pereira, Hélder Ferreira, Joaquim J Pinto, Fausto J. Costa, João |
author_role |
author |
author2 |
Cruz, Inês Calé, Rita Martins, Cristina Pereira, Hélder Ferreira, Joaquim J Pinto, Fausto J. Costa, João |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Caldeira, Daniel Cruz, Inês Calé, Rita Martins, Cristina Pereira, Hélder Ferreira, Joaquim J Pinto, Fausto J. Costa, João |
dc.subject.por.fl_str_mv |
Heart failure Sinus rhythm Platelet aggregation inhibitors Anticoagulants |
topic |
Heart failure Sinus rhythm Platelet aggregation inhibitors Anticoagulants |
description |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z 2018-07-27T14:24:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/34378 |
url |
http://hdl.handle.net/10451/34378 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
World J Meta-Anal 2015 February 26; 3(1): 36-42 2308-3840 10.13105/wjma.v3.i1.36 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Baishideng Publishing Group |
publisher.none.fl_str_mv |
Baishideng Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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|
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1799134422219358208 |