A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study

Detalhes bibliográficos
Autor(a) principal: Alves, JC
Data de Publicação: 2022
Outros Autores: Santos, Ana, Jorge, Patricia, Carreira, L.Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/26983
Resumo: Research Areas: Agriculture; Veterinary Sciences; Zoology
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spelling A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover studyBlood Cell SecretomeOrthobiologicTtriamcinoloneDdogOsteoarthritisPainHipResearch Areas: Agriculture; Veterinary Sciences; ZoologySimple Summary Osteoarthritis is a very common joint disease in dogs. There are multiple treatments described for the disease, but there is still a need for treatments that change disease progression while managing symptoms. For that reason, a growing interest has arisen around biological treatments such as Blood Cell Secretome. The goal of this study was to compare the intra-articular administration of Blood Cell Secretome to its combined administration with triamcinolone in dogs with hip osteoarthritis. Our results show that Blood Cell Secretome improves the overall condition of OA patients and that the combination with triamcinolone lead to faster and longer-lasting improvements. Osteoarthritis (OA) is a growing welfare problem for dogs and a challenge to manage for the clinician, and most therapeutic options aim to control pain. In a randomized, double-blinded, placebo-controlled, 2-way, 2-period crossover study, we aimed to evaluate the use of Blood Cell Secretome (BCS) administrated intra-articularly, with or without the combination with triamcinolone, in dogs with bilateral hip OA. BCS is an acellular orthobiologic containing anti-inflammatory and anabolic proteins produced from the patient's own blood through extended coagulation in a defined environment. Fifteen dogs were initially assigned to a BCS group (BCSG, n = 5), a triamcinolone group (TG, n = 5), or a combination group (BCS+TG, n = 5). All had bilateral hip OA. After a 180-day follow-up, the crossover was performed with BCSG (n = 7) and BCS+TG (n = 7). BCSG received a single intra-articular administration of 3 mL of Blood Cell Secretome, and BCS+TG received BCS plus 0.5 mL of triamcinolone acetonide (40 mg/mL). The volume in BCSG was corrected to 3.5 mL with saline. In all patients, both hips were treated. For treatment follow-up, a copy of the Canine Brief Pain Inventory (divided into pain interference score-PIS and Pain Severity Score-PSS), Liverpool Osteoarthritis in Dogs (LOAD), and Canine Orthopedic Index (COI, divided into function, gait, stiffness, and quality of life) was completed on days 0, 8, 15, 30, 60, 90, 120, 150, and 180. Results were analyzed with the Mann-Whitney U test, effect size, and Kaplan-Meier estimators, followed by the log-rank test. p was set at <0.05. Patients of the sample had a mean age of 9.6 +/- 2.9 years and a body weight of 29.2 +/- 3.9 kg. Seven hips were classified as severe osteoarthritis, and eight were classified as moderate. No differences were found between groups at T0. Significant differences were observed in PSS scores at +8d, with BCS+TG exhibiting better results. PIS, PSS, LOAD, stiffness, and function scores were also lower in BCS+TG from +15 to +60d. The two groups showed similar improvements from +90 to +120d. Kaplan-Meier estimators showed that dogs in BCS+TG showed clinically-important differences for longer, despite a positive result in BCSG. The intra-articular administration of BCS alone was able to improve the overall condition of OA patients. Its combined use with triamcinolone acetonide lead to a faster and longer-lasting improvement in pain scoresMDPIRepositório da Universidade de LisboaAlves, JCSantos, AnaJorge, PatriciaCarreira, L.Miguel2023-01-22T22:34:36Z2022-11-302022-11-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/26983engAlves JC, Santos A, Jorge P, Carreira LM. 2022. A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study. Animals, 12(23):3358. DOI: https://doi.org/10.3390/ani122333582076-261510.3390/ani12233358info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:56:24Zoai:www.repository.utl.pt:10400.5/26983Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:10:31.621757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
title A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
spellingShingle A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
Alves, JC
Blood Cell Secretome
Orthobiologic
Ttriamcinolone
Ddog
Osteoarthritis
Pain
Hip
title_short A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
title_full A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
title_fullStr A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
title_full_unstemmed A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
title_sort A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study
author Alves, JC
author_facet Alves, JC
Santos, Ana
Jorge, Patricia
Carreira, L.Miguel
author_role author
author2 Santos, Ana
Jorge, Patricia
Carreira, L.Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Alves, JC
Santos, Ana
Jorge, Patricia
Carreira, L.Miguel
dc.subject.por.fl_str_mv Blood Cell Secretome
Orthobiologic
Ttriamcinolone
Ddog
Osteoarthritis
Pain
Hip
topic Blood Cell Secretome
Orthobiologic
Ttriamcinolone
Ddog
Osteoarthritis
Pain
Hip
description Research Areas: Agriculture; Veterinary Sciences; Zoology
publishDate 2022
dc.date.none.fl_str_mv 2022-11-30
2022-11-30T00:00:00Z
2023-01-22T22:34:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/26983
url http://hdl.handle.net/10400.5/26983
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Alves JC, Santos A, Jorge P, Carreira LM. 2022. A comparison of intra-articular blood cell secretome and blood cell secretome with triamcinolone acetonide in dogs with osteoarthritis: a crossover study. Animals, 12(23):3358. DOI: https://doi.org/10.3390/ani12233358
2076-2615
10.3390/ani12233358
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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